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7篇 您的检索式:作者名="Jennifer GR"
    题名 作者 年代 出处 被引量
1Is it time for a cardiovascular primary preve-tion trial in the elderly?显示文摘Jennifer GR George B 2007Stroke2007,38,3:1
2Linkage association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism 显示文摘Nicolas R Jennifer GR Christopher JS 2004Am Psychiatry2004,161,:1
3linkage and association ot the mitochondrial aspartate /glutamate carrier SLC25A12 gane with antism显示文摘Nicolas R Jennifer GR Christopher JS 2004Am J Psychiatry2004,161,:1
4Toll - Like Receptor 9 - Dependent Immune Activation by Unmethylated CpG Motifs in Aspergillus fumigatus DNA 显示文摘ZAIDA GR CHARLES AS JENNIFER PW 2008Infect Immun2008,76,5:1
5Linkage association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism显示文摘Nicolas R Jennifer GR Christopher JS 2004Am Psychiatry2004,161,:1
6A'Poly-Portfolio' for Secondary Prevention: A strat- egy to reduce subsequent events by up to 97% over five years 显示文摘Jennifer GR 2005Am JCardio|2005,95,3:1
7CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation显示文摘Gastrointestinal infections are a major cause for serious clinical complications in infants.The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human intestines.While CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to adults.These findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to blood.Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells.Taken together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.Ana Jordan-Paiz Glòria Martrus Fenja L.Steinert Max Kaufmann Adrian F.Sagebiel Renée R.C.E.Schreurs Anne Rechtien Martin E.Baumdick Johannes M.Jung Kimberly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer Jennifer Schroeder-Schwarz Johannes Bvan Goudoever Teunis B.H.Geijtenbeek Marcus Altfeld Steven T.Pals Daniel Perez Paul L.Klarenbeek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher Manuel A.Friese Nathaniel Melling Konrad Reinshagen Madeleine J.Bunders 2023Cellular & Molecular Immunology2023,20,2:0
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