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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Role of microRNAs in the immune system,inflammation and cancer显示文摘MicroRNAs,a key class of gene expression regulators,have emerged as crucial players in various biological processes such as cellular proliferation and differentiation,development and apoptosis.In addition,microRNAs are coming to light as crucial regulators of innate and adaptive immune responses,and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders,such as inflammatory bowel disease,and cancers.In this review,we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. | Jennifer Raisch Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2013 | World Journal of Gastroenterology2013，19，20： | 17 |
| 3 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 4 | Response to strict and liberalized specific carbohydrate dietin pediatric Crohn's disease显示文摘AIM: To investigate the specific carbohydrate diet(SCD) as nutritional therapy for maintenance of remission in pediatric Crohn's disease(CD). METHODS: Retrospective chart review was conducted in 11 pediatric patients with CD who initiated the SCD as therapy at time of diagnosis or flare. Two groups defined as SCD simple(diet alone, antibiotics or 5-ASA) or SCD with immunomodulators(corticosteroids and/or stable thiopurine dosing) were followed for one year and compared on disease characteristics, laboratory values and anthropometrics.RESULTS: The mean age at start of the SCD was 11.8 ± 3.0 years(range 6.6-17.6 years) with five patients starting the SCD within 5 wk of diagnosis. Three patients maintained a strict SCD diet for the study period and the mean time for liberalization was 7.7 ± 4.0 mo(range 1-12) for the remaining patients. In both groups, hematocrit, albumin and ESR values improved while on strict SCD and appeared stable after liberalization(P-value 0.006, 0.002, 0.002 respectively). The majority of children gained in weight and height percentile while on strict SCD, with small loss in weight percentile documented with liberalization. CONCLUSION: Disease control may be attainable with the SCD in pediatric CD. Further studies are needed to assess adherence, impact on mucosal healing and growth. | Jennifer C Burgis Kaylie Nguyen KT Park Kenneth Cox | 2016 | World Journal of Gastroenterology2016，22，6： | 3 |
| 5 | Primary End Point (Six Months) Results of the R anibizumab for E dema of the m A cula in D iabetes (READ-2) Study显示文摘 | Quan Dong Nguyen Syed Mahmood Shah Jeffery S. Heier Diana V. Do Jennifer Lim David Boyer Prema Abraham Peter A. Campochiaro | 2009 | Ophthalmology2009，，11： | 2 |
| 6 | Nationwide Volume and Mortality after Elective Surgery in Cirrhotic Patients显示文摘 | Nicholas G. Csikesz Louis N. Nguyen Jennifer F. Tseng Shimul A. Shah | 2008 | Journal of the American College of Surgeons2008，，1： | 2 |
| 7 | Hepatitis B surface antigen escape mutations: Indications for initiation of antiviral therapy revisited显示文摘Approximately 240 million people are chronically infected with hepatitis B. The implementation of rigorous vaccination programs has led to an overall decrease in the prevalence of this disease worldwide but this may also have led to emergence of viral mutations that can escape the protection of hepatitis B surface antibody. As this phenomenon is increasingly recognized, concern for transmission to vaccinated individuals has also been raised. Herein, we describe two cases where the suspected presence of a hepatitis B surface antigen escape mutation impacted the decision to initiate early antiviral therapy, as well as provide a brief review of these mutations. Our findings described here suggest that a lower threshold for initiating therapy in these individuals should be considered in order to reduce the risk of transmission, as vaccination does not provide protection. | Jennifer Leong Derek Lin Mindie H Nguyen | 2016 | World Journal of Clinical Cases2016，4，3： | 2 |
| 8 | Minimally Invasive Liver Resection for Metastatic Colorectal Cancer: A Multi-Institutional, International Report of Safety, Feasibility, and Early Outcomes显示文摘 | Kevin Tri Nguyen Alexis Laurent Ibrahim Dagher David A. Geller Jennifer Steel Mark T. Thomas Michael Marvin Kadiyala V. Ravindra Alejandro Mejia Panagiotis Lainas Dominique Franco Daniel Cherqui Joseph F. Buell T Clark Gamblin | 2009 | Annals of Surgery2009，，5： | 1 |
| 9 | Minimally Invasive Liver Resection for Metastatic Colorectal Cancer: A Multi-Institutional, International Report of Safety, Feasibility, and Early Outcomes显示文摘 | Kevin Tri Nguyen Alexis Laurent Ibrahim Dagher David A. Geller Jennifer Steel Mark T. Thomas Michael Marvin Kadiyala V. Ravindra Alejandro Mejia Panagiotis Lainas Dominique Franco Daniel Cherqui Joseph F. Buell T Clark Gamblin | 2009 | Annals of Surgery2009，，5： | 1 |
| 10 | Working with Large,Thick PCBs显示文摘 | Jennifer Nguyen Robert Thalhammer | 2008 | SMT Surface Mount Technology Magazine2008，22，4： | 1 |
| 11 | A Prospective, Randomized, Controlled Trial of Single-Incision Laparoscopic (SILS) versus Conventional 3-port Laparoscopic Appendectomy for the Treatment of Acute Appendicitis显示文摘 | Jonathan T. Carter Jennifer A. Kaplan Jason N. Nguyen Matthew Y.C. Lin Stanley J. Rogers Hobart W. Harris | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 12 | Cirrho- sis is not a contraindication to laparoscopic cholecystec- tomy: Results and practical recommendations显示文摘 | Kevin Tri Nguyen Krit Kitisin Jennifer Steel | 2011 | HPB: The Official Journal of the International Hepato Pancreato Biliary Association2011，13，3： | 1 |
| 13 | Robotic pancreaticoduodenectomy in the presence of aberrant or anomalous hepatic arterial anatomy: safety and oncologic outcomes显示文摘 | Trang K. Nguyen Mazen S. Zenati Brian A. Boone Jennifer Steve Melissa E. Hogg David L. Bartlett Herbert J. Zeh Amer H. Zureikat | 2015 | HPB2015，，7： | 1 |
| 14 | Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters显示文摘 | Denise M. Gaughan Paul D. Siegel Michael D. Hughes Chiung‐Yu Chang Brandon F. Law Corey R. Campbell Jennifer C. Richards Stefanos F. Kales Marcia Chertok Lester Kobzik Phuong‐son Nguyen Carl R. O’Donnell Max Kiefer Gregory R. Wagner David C. Christiani | 2014 | Am. J. Ind. Med2014，，7： | 1 |
| 15 | Vascular Endothelial Growth Factor Is a Critical Stimulus for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen Sinan Tatlipinar Syed Mahmood Shah Julia A. Haller Edward Quinlan Jennifer Sung Ingrid Zimmer-Galler Diana V. Do Peter A. Campochiaro | 2006 | American Journal of Ophthalmology2006，，6： | 1 |
| 16 | Cir- rhosis is not a contraindication to laparoscopic cholecys- tectomy: Results and practical recommendations显示文摘 | Kevin Tri Nguyen Krit Kitisin Jennifer Steel | 2011 | HPB: the Official Journal of the International Hepato Pancreato Biliary Association2011，13，3： | 1 |
| 17 | Solder joint characteristics and reliability of lead-free area array packages assembled at various tin-lead soldering process conditions显示文摘 | Jennifer Nguyen David Geiger Daniel Rooney | 2008 | IEEE Transactions on Electronics Packaging Manufacturing2008，31，3： | 1 |
| 18 | Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease显示文摘 | Gratz Scott J Cummings Alexander M Nguyen Jennifer N Hamm Danielle C Donohue Laura K Harrison Melissa M Wildonger Jill O’Connor-Giles Kate M | 2013 | Genetics2013，，4： | 1 |
| 19 | Training guideline for use of propofol in gastrointestinal endoscopy显示文摘 | Robynne Chutkan Jonathan Cohen Mahmood Abedi Marcia Cruz-Correa Jason Dominitz Keith Gersin David Greenwald Sergey Kantsevoy Kris Kowdley Michelle Nguyen Roy Soetikno Jennifer Telford John Vargo | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 20 | Implementation science for the adductor canal block:A new and adaptable methodology process显示文摘BACKGROUND Following the successful Perioperative Surgical Home(PSH)practice for total knee arthroplasty(TKA)at our institution,the need for continuous improvement was realized,including the deimplementation of antiquated PSH elements and introduction of new practices.AIM To investigate the transition from femoral nerve blocks(FNB)to adductor canal nerve blocks(ACB)during TKA.METHODS Our 13-month study from June 2016 to 2017 was divided into four periods:a three-month baseline(103 patients),a one-month pilot(47 patients),a three-month implementation and hardwiring period(100 patients),and a six-month evaluation period(185 patients).In total,435 subjects were reviewed.Data within 30 postoperative days were extracted from electronic medical records,such as physical therapy results and administration of oral morphine equivalents(OME).RESULTS Our institution reduced FNB application(64% to 3%)and increased ACB utilization(36% to 97%)at 10 mo.Patients in the ACB group were found to have increased ambulation on the day of surgery(4.1 vs 2.0 m)and lower incidence of falls(0 vs 1%)and buckling(5% vs 27%)compared with FNB patients(P<0.05).While ACB patients(13.9)reported lower OME than FNB patients(15.9),the difference(P=0.087)did not fall below our designated statistical threshold of P value<0.05.CONCLUSION By demonstrating closure of the“knowledge to action gap”within 6 mo,our institution’s findings demonstrate evidence in the value of implementation science.Physician education,technical support,and performance monitoring were deemed key facilitators of our program’s success.Expanded patient populations and additional orthopedic procedures are recommended for future study. | Nikhil Crain Chun-Yuan Qiu Stephen Moy Shawn Thomas Vu Thuy Nguyen Mijin Lee-Brown Diana Laplace Jennifer Naughton John Morkos Vimal Desai | 2021 | World Journal of Orthopedics2021，12，11： | 1 |
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