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| 1 | Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma显示文摘AIM: To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC).METHODS: Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression difference in HCC tissues and surrounding non-neoplastic liver tissue. FGFR3 expression levels were further determined by immunohistochemical study in 43 cases of HCC.RESULTS: Northern blot results showed the significant over-expression of FGFR3 in HCC tissues, which was consistent with that from DNA microarray. Quantitative real-time PCR demonstrated that the mean ratio of FGFR3 mRNA to glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA in HCC tissue was 0.250, whereas the ratio in non-neoplastic liver tissue was 0.014. Statistical analyses of 43 cases of HCC revealed that HCC scored higher than the matched non-neoplastic liver tissues.Examination of clinicopathological features revealed a strong correlation of over-expression of FGFR3 with poor tumor differentiation and high nuclear grade.CONCLUSION: Over-expression of FGFR3 may play an important role in liver carcinogenesis. FGFR3 may be an ideal candidate as a molecular marker in the diagnosis of HCC and a potential therapeutic target. | Wei-Hua Qiu Bing-Sen Zhou Peiguo G. Chu Wen-Gang Chen Christopher Chung Jennifer Shih Paul Hwu Christopher Yeh Richard Lopez Yun Yen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 2 | 急性运动对ADHD患儿和普通儿童认知表现的影响(英文)显示文摘背景:注意力缺失过动症(attention deficit hyperactivity disorder,ADHD)是一种普通的儿童疾病,影响到大约11%的美国儿童。已有研究支持一段时间的运动有益于儿童的认知表现,数量有限的研究已证明这种影响对ADHD患儿也有效。本研究旨在探讨急性运动对ADHD患儿和普通儿童认知表现的影响。方法:让ADHD患儿和普通儿童接受为期2天、顺序平衡随机的治疗,其中一天为30 min对照状态,另一天为中等强度运动。治疗后对受试者进行认知测试。结果:运动使受试者在斯特鲁测试(Stroop Test)3种情况下的表现均有显著提高,但对伦敦塔测试(Tower of London Test)和连线测试(Trail Making Test)表现影响不大。结论:一段时间的运动能改善ADHD患儿和正常儿童的处理速度和抑制控制,但对其计划和定势转换能力没有影响。 | Aaron T.Piepmeier Chia-Hao Shih Margaret Whedon Lauren M.Williams Matthew E.Davis David A.Henning Se Yun Park Susan D.Calkins Jennifer L.Etnier | 2015 | Journal of Sport and Health Science2015，4，1： | 3 |
| 3 | Candidemia and invasive candidiasis: A review of the literature for the burns surgeon显示文摘 | Jennifer F. Ha Claire M. Italiano Christopher H. Heath Sophia Shih Suzanne Rea Fiona M. Wood | 2010 | Burns2010，，2： | 1 |
| 4 | Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells显示文摘 | Shu-Jun Chiu Ching-Hui Hsaio Ho-Hsing Tseng Yu-Han Su Wen-Ling Shih Jeng-Woei Lee Jennifer Qiu-Yu Chuah | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 5 | Loss of SIRT4decreases GLT-1-dependent glutamate uptake and increasessensitivity to kainic acid显示文摘 | Jennifer Shih Liu Lei Andrew Mason | 2014 | J Neurochem2014，131，5： | 1 |
| 6 | Bullous Pemphigoid: Readability, Quality, and Treatments of Online Health Resources显示文摘Dear Editor,Bullous pemphigoid(BP)is an autoimmune blistering disease that disproportionately affects the elderly,1 a population in which limited health literacy is a known barrier to health outcomes.The 2003 National Assessment of Adult Literacy survey found that among patients older than 65,59%had“basic”or“below basic”literacy,and only 3%were“proficient.”2 Despite increased utilization of the internet to seek health information,including among the elderly,3 the accessibility of online BP resources remain unknown.Herein,we examine the readability and quality of online resources on BP. | Terri Shih Natalie Villa Jennifer L.Hsiao Vivian Y.Shi | 2022 | International Journal of Dermatology and Venereology2022，5，1： | 0 |
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