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| 1 | 62 kaBP以来湖光岩玛珥湖沉积物有机碳同位素记录及古气候环境意义显示文摘湖光岩玛珥湖HUG B孔岩心记录了62kaBP以来的古气候、古环境变化信息。全岩有机碳同位素组成(δ13CTOC)分析表明,62kaBP以来δ13CTOC值变化比较明显,其变化范围为-28.5‰~-15.5‰。结合孢粉和有机地球化学指标进行综合分析,湖光岩玛珥湖δ13CTOC变化曲线可划分为6个演化阶段:62~58和48~40.5kaBP两个时段的δ13CTOC值偏负,沉积物中有机质主要来源于热带—亚热带地区的陆生C3森林植被,反映了温暖潮湿的气候环境;58~48和40.5~17.2kaBP期间δ13CTOC值明显偏正,沉积物中有机质主要源自C4草本植物,反映了湖光岩地区有效降水量减少、干旱程度增加导致湖光岩玛珥湖湖面下降,大量C4草本植物生长在暴露的湖滨岸;17.2~4kaBP时段内δ13CTOC值尽管存在更加频繁的波动,但总体呈现逐渐偏负的趋势,反映了暖湿和冷干气候多次交替但总体上逐渐变暖、变湿的气候环境;4kaBP以来δ13CTOC值存在逐渐偏正的趋势,虽然不排除人类活动的影响,但很可能反映了干旱程度的再次增加。综合分析表明,有效降水量(降水量-蒸发量)是控制湖光岩玛珥湖地区C3/C4植物相对生物量变化的主导因素。湖光岩玛珥湖有机碳同位素的研究结果支持区域气候环境而不是大气CO2浓度变化是末期冰期以来热带低纬度地区C3/C4植被相对生物量变化的主要原因。 | 刘强 顾兆炎 刘嘉麒 游海涛 吕厚远 储国强 祁向雷 Jorg F W Negendank Jens Mingram Georg Schettler | 2005 | 海洋地质与第四纪地质2005，25，2： | 34 |
| 2 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging显示文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. | Georg Wimmer Michael Gadermayr Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl | 2019 | World Journal of Gastroenterology2019，25，10： | 2 |
| 5 | Telbivudine Improves Renal Function in Patients With Chronic Hepatitis B显示文摘 | Edward J. Gane Gilbert Deray Yun-Fan Liaw Seng Gee Lim Ching-Lung Lai Jens Rasenack Yuming Wang George Papatheodoridis Adrian Di Bisceglie Maria Buti Didier Samuel Alkaz Uddin Sophie Bosset Aldo Trylesinski | 2014 | Gastroenterology2014，，1： | 2 |
| 6 | Adhesive small bowel obstruction after appendectomy in children: comparison between the laparoscopic and open approach显示文摘 | Kuo Jen Tsao Shawn D. St Peter Patricia A. Valusek Scott J. Keckler Susan Sharp George W. Holcomb Charles L. Snyder Daniel J. Ostlie | 2007 | Journal of Pediatric Surgery2007，，6： | 2 |
| 7 | Atmosphere sounding by GPS radio occultation: first result from CHAMP显示文摘 | Jens Wickert Christoph Reigber Georg Beyerle | 2001 | Geophysical Research Letters2001，28，17： | 1 |
| 8 | Effect of subliminal stimuli on consumer behavior:Negative evidence显示文摘 | George S.G Jennings L.B | | 0，，： | 1 |
| 9 | An advanced evolutionary strategy with an adaptive penalty function for mixed-discrete structural optimization显示文摘 | CARSTEN EBENAU JENS ROTTSCH~FER GEORG THIERAUF | 2005 | Advances in Engineering Software2005，36，1： | 1 |
| 10 | A numerical study on the effects of Taiwan topography on a convective line during the Mebyu season 显示文摘 | Wang Chung Chieh Chen George Tai Jen Chen Tzu Chin | 2005 | Mon Wea Rev2005，133，11： | 1 |
| 11 | Altered carbon cycling and coupled changes in Early Cretaceous weathering patterns: Evidence from integrated carbon isotope and sandstone records of the western Tethys显示文摘 | Ulrich Georg Wortmann Jens Olaf Herrle Helmut Weissert | 2004 | Earth and Planetary Science Letters2004，，1： | 1 |
| 12 | Postconditioning with a CpG containing Oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model显示文摘 | Se-Chan Kim Shuijing Wu Xiangming Fang Jens Neumann Lars Eichhorn Grigorij Schleifer Olaf Boehm Rainer Meyer Stilla Frede Andreas Hoeft Georg Baumgarten Pascal Knuefermann | 2014 | Life Sciences2014，，： | 1 |
| 13 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 14 | Efficient chemoselective earboxylation of aromatics to arylearboxylic acids with a superelectro-philically activated carbon dioxide-Al2C16/Al system 显示文摘 | George A O Bela T Jens P J | 2002 | J Am Chem Soc2002，124，11： | 1 |
| 15 | Using motion capture to assess colonoscopy experience level显示文摘AIM: To study technical skills of colonoscopists using a Microsoft Kinect? for motion analysis to develop a tool to guide colonoscopy education.RESULTS: Ten experienced endoscopists(gastroenterologists, n = 2; colorectal surgeons, n = 8) and 11 novices participated in the study. A Microsoft Kinect? recorded the movements of the participants during the insertion of the colonoscope. We used a modified script from Microsoft to record skeletal data. Data were saved and later transferred to MatLab for analysis and the calculation of statistics. The test was performed on a physical model, specifically the 'Kagaku Colonoscope Training Model'(Kyoto Kagaku Co. Ltd, Kyoto, Japan). After the introduction to the scope and colonoscopy model, the test was performed. Seven metrics were analyzed to find discriminative motion patterns between the novice and experienced endoscopists: hand distance from gurney, number of times the right hand wasused to control the small wheel of the colonoscope, angulation of elbows, position of hands in relation to body posture, angulation of body posture in relation to the anus, mean distance between the hands and percentage of time the hands were approximated to each other.RESULTS: Four of the seven metrics showed discriminatory ability: mean distance between hands [45 cm for experienced endoscopists(SD 2) vs 37 cm for novice endoscopists(SD 6)], percentage of time in which the two hands were within 25 cm of each other [5% for experienced endoscopists(SD 4) vs 12% for novice endoscopists(SD 9)], the level of the right hand below the sighting line(z-axis)(25 cm for experienced endoscopists vs 36 cm for novice endoscopists, P < 0.05) and the level of the left hand below the z-axis(6 cm for experienced endoscopists vs 15 cm for novice endoscopists, P < 0.05). By plotting the distributions of the percentages for each group, we determined the best discriminatory value between the groups. A pass score was set at the intersection of the distributions, and the consequences of the standard were explored for each test. By using the contrasting group method, we showed a discriminatory value of Z = 1.51 to be the pass/fail value of the data showing discriminatory ability. The pass score allowed all ten experienced endoscopists as well as five novice endoscopists to pass the test.CONCLUSION: Identified metrics can be used to discriminate between experienced and novice endoscopists and to provide non-biased feedback. Whether it is possible to use this tool to train novices in a clinical setting requires further study. | Morten Bo Svendsen Louise Preisler Jens Georg Hillingsoe Lars Bo Svendsen Lars Konge | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，5： | 1 |
| 16 | Approaches towards specifically functionalized cascade macromolecules:dendrimers with incoporated metal binding sites and their palladium(Ⅱ) and copper(Ⅱ) complexs显示文摘 | GEORGE R N JENS G CHARLES N M | | 0，，06： | 1 |
| 17 | Micro‐scale determinants of bacterial diversity in soil显示文摘 | Michiel Vos Alexandra B. Wolf Sarah J. Jennings George A. Kowalchuk | 2013 | FEMS Microbiol Rev2013，，6： | 1 |
| 18 | Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7显示文摘 | Udo Rüb Ludger Sch?ls Henry Paulson Georg Auburger Pawel Kermer Joanna C. Jen Kay Seidel Horst-Werner Korf Thomas Deller | 2013 | Progress in Neurobiology2013，，： | 1 |
| 19 | Virus‐induced multiple gene silencing to study redundant metabolic pathways in plants: Silencing the starch degradation pathway in Nicotiana benthamiana显示文摘 | Gavin M. George Rolene Bauer Andreas Blennow Jens Kossmann James R. Lloyd | 2012 | Biotechnology Journal2012，，7： | 1 |
| 20 | Arrhythmogenic right ventricular cardiomyopathy: diagnostic and prognostic value of the cardiac MRI in relation to arrhythmia-free survival显示文摘 | Dagmar I. Keller Stefan Osswald Jens Bremerich Georg Bongartz Thomas A. Cron Patrick Hilti Matthias E. Pfisterer Peter T. Buser | 2003 | The International Journal of Cardiac Imaging2003，，： | 1 |
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