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| 1 | Limited endoscopic sphincterotomy plus large balloon dilation for choledocholithiasis with periampullary diverticula显示文摘AIM: To investigate the effectiveness and safety of limited endoscopic sphincterotomy (EST) plus large balloon dilation (LBD) for removing choledocholithiasis in patients with periampullary diverticula (PAD). METHODS: A total of 139 patients with common bile duct (CBD) stones were treated with LBD (10-20 mm balloon diameter) after limited EST. Of this total, 73 patients had PAD and 66 patients did not have PAD (controls). The results of stone removal and complications were retrospectively evaluated. RESULTS: There were no significant differences between the PAD and the control groups in overall successful stone removal (94.5% vs 93.9%), stone removal in first session (69.9% vs 81.8%), mechanical lithotripsy (12.3% vs 13.6%), and complications (11.0% vs 7.6%). Clinical outcomes were also similar between the types of PAD, but the rate of stone removal in first session and the number of sessions were significantly lower and more frequent, respectively, in type B PAD (papilla located near the diverticulum) than controls [23/38 (60.5%) vs 54/66 (81.8%), P = 0.021; and 1 (1-2) vs 1 (1-3), P = 0.037, respectively] and the frequency of pancreatitis was significantly higher in type A PAD (papilla located inside or in the margin of the diverticulum) than in controls (16.1% vs 3.0%, P = 0.047). CONCLUSION: Limited EST plus LBD was an effective and safe procedure for removing choledocholithiasis in patients with PAD. However, some types of PAD should be managed with caution. | Hyung Wook Kim Dae Hwan Kang Cheol Woong Choi Jong Hwan Park Jin Ho Lee Min Dae Kim Il Doo Kim Ki Tae Yoon Mong Cho Ung Bae Jeon Suk Kim Chang Won Kim Jun Woo Lee | 2010 | World Journal of Gastroenterology2010，16，34： | 26 |
| 2 | Effect of Korean red ginseng on blood pressure and nitric oxide production显示文摘AIM: To investigate the effect of crude saponin and non-saponin fraction of Korean red ginseng (KRG) on the blood pressure and nitric oxide (NO) production in the conscious rats and cultured endothelial cell line, ECV 304 cells. METHODS: Systolic blood pressure and heart rate were monitored in the conscious rats. Nitric oxide levels and the expression of nitric oxide synthase were measured by a spectrophotometric assay using Griess reagents and Western blotting, respectively. Nitric-oxide synthase activity was measured based on the conversion rate of [3H]arginine to [3H]citrulline. RESULTS: Systolic blood pressure was decreased by crude saponin (100 mg/kg, iv) of KRG in the conscious control and one-kidney, one-clip Goldblatt hypertensive (IK, 1C-GBH) rats. The hypotensive effect induced by crude saponin of KRG reached maximum at 2 - 4 min and slowly recovered after 20 min to the initial level in both groups. Crude saponin of KRG induced tachycardia in the conscious rats but induced bradycardia in the | JEON Byeong Hwa KIM Cuk Seong KIM Hoe-Suk PARK Jin-Bong NAM Ki Yeul CHANG Seok Jong | 2000 | Acta Pharmacologica Sinica2000，21，12： | 12 |
| 3 | Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice显示文摘Objective:To isolate and identify the anticancer compound against proliferation of human colon cancer cells from ethyl acetate(EtOAc)extract ol Phellinus linteus grown on germinated brown rice(PB).Methods:EtOAc extract of PB was partitioned with n-hexane,EtOAc,and water-saturated n-butanol.Anticancer compound of n-hexane layer was isolated and identified by HPLC and NMR,respectively.Cytotoxicity against HT-29 cells was tested by SRB assay.Results:The n-hexane layer obtained after solvent fractionation of PB EtOAc extracts showed a potent anticancer activity against the HT-29 cell line.Atractylenolide I,a eudesmane-type sesquiterpene lactone,a major anticancer substance of PB,was isolated from the n-hexane layer by silica gel column chromatography and preparative-HPLC.This structure was elucidated by one-and two-dimensional NMR spectroscopic data.Atractylenolide I has not been reported in mushrooms or rice as of yet.The isolated compound dose-dependently inhibited the growth of HT-29 human colon cancer cells.Conclusions:Atractylenolide I might contribute to the anticancer effect of PB. | Tae-Il Jeon Chang-Hwa Jung Jeong-Yong Cho Dong Ki Park Jae-Hak Moon | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，10： | 9 |
| 4 | Iodized oil uptake assessment with cone-beam CT in chemoembolization of small hepatocellular carcinomas显示文摘AIM:To evaluate the utility of assessing iodized oil uptake with cone-beam computed tomography(CT)in transarterial chemoembolization(TACE)for small he-patocellular carcinoma(HCC).METHODS:Cone-beam CT provided by a biplane flat-panel detector angiography suite was performed on eighteen patients(sixteen men and two women;41-76 years;mean age,58.9 years)directly after TACE for small HCC(26 nodules under 30 mm;mean diam-eter,11.9 mm;range,5-28 mm).The pre-procedural locations of the tumors were evaluated using tripha-sic multi-detector row helical computed tomography(MDCT).The tumor locations on MDCT and the iodized oil uptake by the tumors were analyzed on cone-beam CT and on spot image directly after the procedures.RESULTS:All lesions on preprocedural MDCT were de-tected using iodized oil uptake in the lesions on cone-beam CT(sensitivity 100%,26/26).Spot image depictediodized oil uptake in 22 of the lesions(sensitivity 85%).The degree of iodized oil uptake was overestimated(9%,2/22)or underestimated(14%,3/22)on spot image in f ive nodules compared with that of cone-beam CT.CONCLUSION:Cone-beam CT is a useful and conve-nient tool for assessing the iodized oil uptake of small hepatic tumors(< 3 cm)directly after TACE. | Ung Bae Jeon Jun Woo Lee Ki Seok Choo Chang Won Kim Suk Kim Tae Hong Lee Yeon Joo Jeong Dae Hwan Kang | 2009 | World Journal of Gastroenterology2009，15，46： | 8 |
| 5 | Comparison of brush and basket cytology in differential diagnosis of bile duct stricture at endoscopic retrograde cholangiopancreatography显示文摘BACKGROUND: A previous report has identified a significantly higher sensitivity of cancer detection for dedicated grasping basket than brushing at endoscopic retrograde cholangiopancreatography (ERCP). This study aimed to compare the diagnostic accuracy of Geenen brush and Dormia basket cytology in the differential diagnosis of bile duct stricture.METHOD: The current study enrolled one hundred and fourteen patients who underwent ERCP with both Geenen brush and Dormia basket cytology for the differential diagnosis of bile duct stricture at our institution between January 2008 and December 2012.RESULTS: We adopted sequential performances of cytologic samplings by using initial Geenen brush and subsequent Dormia basket cytology in 59 patients and initial Dormia basket and subsequent Geenen brush cytology in 55 patients.Presampling balloon dilatations and biliary stentings for the stricture were performed in 17 (14.9%) and 107 patients (93.9%),respectively. The sensitivity, specificity, positive predictive value,negative predictive value, and accuracy of Geenen brush cytology for the diagnosis of malignant bile duct stricture were 75.0%,100.0%, 100.0%, 66.7% and 83.3%, respectively, and those of Dormia basket cytology were 64.5%, 100.0%, 100.0%, 58.5% and 76.3%, respectively (P=0.347 and 0.827 for sensitivity and accuracy, respectively). The good and excellent cellular yields (≥ grade 2) were obtained by Geenen brush and Dormia basket cytology in 88 (77.2%) and 79 (69.3%) patients, respectively.CONCLUSION: The sensitivity, specificity and accuracy of biliary sampling with a Dormia basket are comparable to those with conventional Geenen brush cytology in the detection of malignant bile duct stricture. | Ki Bae Bang Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 5 |
| 6 | Appropriate empirical antibiotic use and 30-d mortality in cirrhotic patients with bacteremia显示文摘AIM: To analyze whether prompt and appropriate empirical antibiotic(AEA) use is associated with mortality in cirrhotic patients with bacteremia. METHODS: A total of 102 episodes of bacteremia in 72 patients with cirrhosis were analyzed. AEA was defined as a using or starting an antibiotic appropriate to the isolated pathogen at the time of bacteremia. The primary endpoint was 30-d mortality. RESULTS: The mortality rate at 30 d was 30.4%(31/102 episodes). Use of AEA was associated with better survival at 30 d(76.5% vs 46.9%, P = 0.05), and inappropriate empirical antibiotic(IEA) use was an independent factor associated with increased mortality(OR = 3.24; 95%CI: 1.50-7.00; P = 0.003, adjusted for age, sex, ChildPugh Class, gastrointestinal bleeding, presence of septic shock). IEA use was more frequent when the isolated pathogen was a multiresistant pathogen, and when infection was healthcare-related or hospital-acquired. CONCLUSION: AEA use was associated with increased survival of cirrhotic patients who developed bacteremia. Strategies for AEA use, tailored according to the local epidemiological patterns, are needed to improve survival of cirrhotic patients with bacteremia. | Hyun Park Ki Jun Jang Won Jang Sang Hoon Park Ji Young Park Tae Joo Jeon Tae Hoon Oh Won Chang Shin Won-Choong Choi Dong Hyun Sinn | 2015 | World Journal of Gastroenterology2015，21，12： | 4 |
| 7 | Association of kinase insert domain-containing receptor ( KDR ) gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women显示文摘 | HyungChul Rah Young Joo Jeon Bo Eun Lee Dong Hee Choi Tae Ki Yoon Woo Sik Lee Nam Keun Kim | 2012 | Fertility and Sterility2012，，： | 2 |
| 8 | Foldable and washable textile-based OLEDs with a multi-functional near-room-temperature encapsulation layer for smart e-textiles显示文摘Wearable electronic devices are being developed because of their wide potential applications and user convenience.Among them,wearable organic light emitting diodes(OLEDs)play an important role in visualizing the data signal processed in wearable electronics to humans.In this study,textile-based OLEDs were fabricated and their practical utility was demonstrated.The textilebased OLEDs exhibited a stable operating lifetime under ambient conditions,enough mechanical durability to endure the deformation by the movement of humans,and washability for maintaining its optoelectronic properties even in water condition such as rain,sweat,or washing.In this study,the main technology used to realize this textile-based OLED was multi-functional nearroom-temperature encapsulation.The outstanding impermeability of TiO_(2)film deposited at near-room-temperature was demonstrated.The internal residual stress in the encapsulation layer was controlled,and the device was capped by highly crosslinked hydrophobic polymer film,providing a highly impermeable,mechanically flexible,and waterproof encapsulation. | So Yeong Jeong Hye Rin Shim Yunha Na Ki Suk Kang Yongmin Jeon Seungyeop Choi Eun Gyo Jeong Yong Cheon Park Ha-Eun Cho Junwoo Lee Jeong Hyun Kwon Sung Gap Im Kyung Cheol Choi | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 9 | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy显示文摘 | Kim Sang Soo Song Sang Heon Kim In Joo Jeon Yun Kyung Kim Bo Hyun Kwak Ihm Soo Lee Eun Kyung Kim Yong Ki | 2013 | Diabetes Care2013，，3： | 1 |
| 10 | Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet显示文摘 | Jang SM Yee ST Choi J Choi MS Do GM Jeon SM Yeo J Kim MJ Seo KI Lee MK | 2009 | Int Immunopharmacol2009，9，1： | 1 |
| 11 | Antibacterial effect of chitooligosaccha- rides produced by bioreactor 显示文摘 | Jeon Y J Park PJ Ki SK | 2001 | Carbohydr Polym2001，44，1： | 1 |
| 12 | Vinpocetine inhibits IXIF-Kappa Bdependent inflammation via an IKK-dependent but PDE-inde-pendent mechanism显示文摘 | Jeon KI Xu X Aizawa T et a1 | 2010 | Proc Natl Acad Sci USA2010，107，21： | 1 |
| 13 | Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent butPDE-independent mechanism显示文摘 | Jeon KI Xu X Aizawa T | | 0，，21： | 1 |
| 14 | Chitooligosaccharides decreases plasma lipid levels in healthy men显示文摘 | Cheong-Rak Choi Eun-Kyung Kim Yon-Suk Kim Jae-Young Je Sang-Hyun An Jae Dong Lee Joon Ho Wang Seung Seog Ki Byong-Tae Jeon Sang-Ho Moon Pyo-Jam Park | 2012 | International Journal of Food Sciences and Nutrition2012，，1： | 1 |
| 15 | Vinpocetine inhibits NF-kappaB-depend- ent inflammation via an IKK-dependent but PDE-independent mechanism 显示文摘 | Jeon KI Xu X Aizawa T | 2010 | Proc Natl Acad Sci U S A2010，107，21： | 1 |
| 16 | 显示文摘 | Jue DM Jeon KI Jeong JY | 1999 | J Korean Med Sci1999，14，3： | 1 |
| 17 | Dual effect of oxidative stress on NF-kappa B activation in HeLa cells显示文摘 | Byun MS Jeon KI Choi JW | 2002 | Exp Mol Med2002，34，5： | 1 |
| 18 | Vinpocetine inhibits IXIF-Kappa Bdependent inflammation via an lKK-dependenl but PDE-inde pendent mechanism显示文摘 | Jeon KI Xu X Aizawa T | 2010 | Proc Nail Acad Sci USA2010，107，： | 1 |
| 19 | Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway显示文摘 | Hyo Sang Go Ki Chan Kim Chang Soon Choi Se Jin Jeon Kyung Ja Kwon Seol-Heui Han Jongmin Lee Jae Hoon Cheong Jong Hoon Ryu Chong-Hyun Kim Kwang Ho Ko Chan Young Shin | 2012 | Neuropharmacology2012，，6： | 1 |
| 20 | Vinpocetine inhibits NF- kappa B-dependent inflammation via an IKK-dependent but PDE independent mechanism显示文摘 | Jeon KI Xu X Aizawa T | 2010 | Proc Natl Acad Sci U S A2010，107，21： | 1 |
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