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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Platelets: Linking Hemostasis and Cancer显示文摘 | Shashank Jain John Harris Jerry Ware | 2010 | Arteriosclerosis, Thrombosis, and Vascular Biology2010，，12： | 1 |
| 3 | To Be or not to Be : The Nation - Centric World Order under Globalization 显示文摘 | Harris Jerry | 2005 | Science & Society2005，69，6： | 1 |
| 4 | Seismic attenuation tomography using the frequency shift method显示文摘 | QUAN You-li HARRIS Jerry M | 1997 | Geophysics1997，62，3： | 1 |
| 5 | Platelets: Linking Hemostasis and Cancer显示文摘 | Shashank Jain John Harris Jerry Ware | 2010 | Arteriosclerosis Thrombosis and Vascular Biology2010，，12： | 1 |
| 6 | 用Agilent 7000 GC/MS/MS分析豆奶中的八种植物雌激素显示文摘植物雌激素是来源于植物.分子结构和雌激素相似,在体肉有雌激素样作用的一组非类固醇多酚化合物.分为异黄酮.类黄酮类、木酚素类和coumestans,主要存在于大豆.三叶草、紫花苜蓿、黄豆,豌豆等豆科植物中。与合成激素不同,天然植物雌激素没有副作用。但是随着合成激素和动物雌激素在废水中的排放.植物雌激素也被认为会干扰鱼的内分泌。 | Imma Ferrer E.Michael Thurman Melissa Churley Harry Prest Phil Stremple Phil Wylie Jerry Zweigenbaum | 2010 | 食品安全导刊2010，，7： | 1 |
| 7 | Critical Role of Macrophage 12/15-Lipoxygenase for Atherosclerosis in Apolipoprotein E–Deficient Mice显示文摘 | Yuqing Huo Lei Zhao Matthew Craig Hyman Pavel Shashkin Brian L. Harry Tracy Burcin S Bradley Forlow Matthew A. Stark David F. Smith Sean Clarke Suseela Srinivasan Catherine C. Hedrick Domenico Praticò Joseph L. Witztum Jerry L. Nadler Colin D. Funk Klaus | 2004 | Circulation2004，，14： | 1 |
| 8 | Seismic attenuation tomography using the frequency shift method 显示文摘 | Youli Quan Harris Jerry M | 1997 | Geophys1997，63，3： | 1 |
| 9 | Wave equation tomographyin baseband with phase correction from the first arrival traveltimes显示文摘We use the first arrival traveltime to correct the phase distortion in a nonlinear wave equation inversion scheme.This improves the precision of tomographic reconstruction of a velocity structure with large variations and helps solve the ill-posed problem of wave equation inversion.When the variation of the velocity distribution is large,general non-linear wave equation inversions are very ill-posed and for such strong nonlinear we can not obtain a correct inversion.One of main reasons is that the calculated and observed phase of the wavefield differs greatly if the initial model is far from the true model.This leads to highly mismatched phase between the calculated and the observed wave field.This is so-called'Cycle Skipping'problem in the full waveform inversion.The phase mismatch is even more pronounced if a high operating frequency is employed in order to increase resolution.To address this problem,we use the first arrival to'demodulate'the wave field in the frequency domain with a goal of restoring the phase of wave field.Then we minimize an objective function consisting of so called'demodulated'wave field to solve wave equation inversion problem.In this way,we find that the inversion is much improved,and when the velocity perturbation in a complicated model reaches 35%,we can still obtain a good inversion.A computer simulation shows that our method is very robust for acoustical wave inversion with good reconstruction precision. | YIN Feng Jerry HARRIS | 2017 | 石油物探2017，56，1： | 0 |
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