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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Differential roles of exoloop 1 of the human follicle-stimulating hormone receptor in hormone binding and receptor activation显示文摘 | Ji I Ji TH | 1995 | J Biol Chem1995，270，15： | 1 |
| 3 | Guidelines for the use of deep sedation and general anesthesia for GI endoscopy显示文摘 | Faigel DO Baron TH Goldstein JI | 2002 | Gastrointest Endosc2002，56，5： | 1 |
| 4 | Role of pigment epitheliura-derived factor in the involution of hemangioma:autocrine growth inhibition of hemangioma-derived endothelial cells显示文摘 | Kim KJ Yun JH Heo JI Lee EH Min HS Choi TH Cho CH | 2014 | 454(2) :282-82014，454，2： | 1 |
| 5 | cAMP-response element- binding 3-like protein 1 ( CREB3L1 ) is required for decidualization and its expression is decreased in women with endometriosis显示文摘 | Ahn JI Yoo JY Kim TH | 2016 | Curt Mol Med2016，16，3： | 1 |
| 6 | Gastrointestinal stromal tumors: computed tomographic features and prediction of malignant risk from computed tomogTaphic imaging显示文摘 | Yang TH Hwang JI Yang MS | 2007 | Chin Med Assoc2007，70，9： | 1 |
| 7 | Gonadotropin-releasing hormone receptor couples to multiple G-proteins in rat gonadotrophs and in GGH3 cells:evidence from palmitoylation and overexpression of G proteins显示文摘 | Stanislaus D Ponder S Ji TH | 1998 | Biol Reprod1998，59，： | 1 |
| 8 | Gastrointestinal stromal tumors:computed tomographie features and prediction of malig- nant risk from computed tomographic imaging 显示文摘 | YANG TH HWANG JI YANG MS | 2007 | J Chin Med Assoc2007，70，9： | 1 |
| 9 | Detection of human bocavirus in children hospitalized because of acute gastroenteritis显示文摘 | Lee JI Chung JY Han TH | 2007 | J Infect Dis2007，196，7： | 1 |
| 10 | Detection of human bocavirus in chil- dren hospitalized because of acute gastroenteritis 显示文摘 | Ji LE Chung JY Han TH | 2007 | J Infect Dis2007，196，7： | 1 |
| 11 | Gastrointestial stro-mal tumors j computed tomographic features and prediction ofmalignant risk from computed tomographic imaging 显示文摘 | Yang TH Hwang JI Yang MS | 2007 | JChin Med Assoc2007，70，9： | 1 |
| 12 | Evaluation of wet-cupping therapy for persistent non-specific low back pain:a randomised,waiting-list controlled,open-label,parallel-group pilot trial显示文摘 | Kim JI Kim TH Lee MS | | 0，，： | 1 |
| 13 | Gastrointestinal stromal tumors : computed tomographic features and prediction of malignant risk from computed tomographic imaging 显示文摘 | Yang TH Hwang JI Yang MS | 2007 | J Chin Med Assoc2007，70，9： | 1 |
| 14 | Gastrointestinal:Scrub typhus inducedacute gastric ulceration显示文摘 | SW Cho JI Hwang TH Oh | 2010 | Journal of Gastroenterology and Hepatol-ogy2010，25，： | 1 |
| 15 | Safety and efficacy of trans-luminal balloon angioplasty using a compliant balloon forsevere cerebral vasospasm after an aneurysmal subarachnoid hemorrhage 显示文摘 | Choi BJ Lee TH Lee JI | 2011 | J Korean Neurosurg Soc2011，49，3： | 1 |
| 16 | Gastrointestinal stro- mal tumors: computed tomographie features and prediction of malignant risk from computed tomographic imaging 显示文摘 | Yang TH Hwang JI Yang MS | 2007 | Chin Med ASSOC2007，70，9： | 1 |
| 17 | Noncommunicating syringomyelia following occlusion of central canal in rats:experimental model and histological findings显示文摘 | Milhorat TH Nobandegani F Miller JI | 1993 | J Neurosurg1993，78，2： | 1 |
| 18 | Percutaneous endoscopic cecostomy:a case series显示文摘 | Rarnage JI Jr Baron TH | 2003 | Gastrointest Endose2003，57，6： | 1 |
| 19 | Anatomical basis of syringomyelia occurring with hindbrain lesions 显示文摘 | Millerat TH Miller JI Johnsion WD | 1993 | Neurosurg1993，32，： | 1 |
| 20 | Relapse and relapse prevention显示文摘 | Brandon TH Vidrine JI Litvin EB | 2007 | Annu Rev Clin Psychol2007，3，： | 1 |
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