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| 1 | Spatiotemporal characteristics, patterns, and causes of land-use changes in China since the late 1980s显示文摘Land-use/land-cover 变化(LUCC ) 有连接到人和自然相互作用。瓷器 Land-Use/cover 数据集(CLUD ) 从 1980 年代末在 5 年的间隔定期被更新到 2010,与基于 Landsat TMETM+ 图象的标准过程。陆地使用动态区域化方法被建议分析主要陆地使用变换。在国家规模的陆地使用变化的空间与时间的特征,差别,和原因然后被检验。主要调查结果如下被总结。越过中国的陆地使用变化(LUC ) 在最后 20 年(19902010 ) 里在空间、时间的特征显示了一个重要变化。农田变化的区域在南方减少了并且在北方,而是仍然是的全部的区域增加了几乎未改变。回收农田从东北被转移到西北。布满建筑物陆地很快膨胀了,主要在东方被散布,并且逐渐地展开到中央、西方的中国。树林首先减少了,然后增加但是荒芜的区域是反面。草地继续减少。在中国的 LUC 的不同空间模式被发现在之间迟了第 20 世纪并且早第 21 世纪。原版 13 个 LUC 地区在一些地区被边界的变化由 15 个单位代替。包括的这些变化(1 ) 的主要空间特征加速的扩大布满建筑物在 Huang-Huai-Hai 区域,东南的沿海的区域,长江的中流区域,和四川盆登陆;(2 ) 从东北中国和东方内部蒙古在北方转移了陆地开垦到绿洲在西北中国的农业区域;(3 ) 从在到稻的东北中国的喂雨的农田的连续转变回答;并且(4 ) 为在内部蒙古,黄土高原,和西南的多山的区域的南部的农业牧剧的交错群落的格林工程的谷物的有效性。在最后二十年,尽管在北方的气候变化在农田影响了变化,政策规定和经济驱动力仍然是越过中国的 LUC 的主要原因。在第 21 世纪的第一十年期间,在陆地使用模式驾驶了变化的人为的因素从单程的陆地开发转移了强调到开发和保存。动态区域化方法被用来在单位的 zoning 边界,地区的内部特征,和生长和减少的空间模式分析变化。结果揭示了变化过程的模式,也就是 LUC 的过程和在在不同阶段的特征的地区性的差别。地区的生长和减少在这动态 LUC zoning,在统一边界的变化,和在前者和后者十年之间的变化紧张的特征期间被检验。在为在不同类型和陆地使用的不同区域的变化的陆地使用和原因的模式和过程之间的其他的转变的模式被探索。 | LIU Jiyuan KUANG Wenhui ZHANG Zengxiang XU Xinliang QIN Yuanwei NING Jia ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhe WU Shixin SHI Xuezheng JIANG Nan YU Dongsheng PAN Xianzhang CHI Wenfeng | 2014 | Journal of Geographical Sciences2014，24，2： | 245 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 4 | No-reflow protection and long-term efficacy for acute myocardial infarction with Tongxinluo: a randomized double-blind placebo- controlled multicenter clinical trial (ENLEAT Trial)显示文摘在紧急情况以后的背景没有回流为尖锐的圣片断举起的经皮的冠的干预(一种总线标准) 心肌的梗塞(STEMI ) 与严重预后有关。这研究的目的是评估 Tongxinluo 的功效,繁体中文药,在在为 219 个病人全部的 STEMI.Methods A 的紧急情况一种总线标准以后的没有回流和梗塞区域上(女性 31 ,14%)从九个临床的中心为 STEMI 经历紧急情况一种总线标准连续地在这被注册使随机化,双窗帘,控制安慰剂, multicenter 对2009年5月的从2007年1月的临床的试用。所有病人随机被划分成 Tongxinluo 在装载的组(n=108 ) 和控制组(n=111 ) ,给定的 Tongxinluo 或安慰剂在紧急情况一种总线标准前分别地为 2.08 g 开 asprin 300 mg 和 clopidogrel 300 mg 一起,然后为在一种总线标准以后的六个月三倍每日的 1.04 g。圣片断举起被心电图在住院记录并且 1, 2, 6, 12,在冠的汽球膨胀到以后的 24 个小时评估心肌的没有流动;在有静态的单个光子的排放的 STEMI 计算了断层摄影术( SPECT )决定在那里的梗塞 area.Results 不是在性别的统计意义以后, 17 个片断的心肌的灌注分数在白天 7 和白天 180 上被评估,年龄经过历史,胸疼痛, onset-to-reperfusion 时间, Killip 分类,就在一种总线标准前后的 TIMI 流动等级,在药治疗的任何一个在follow 在上面期间例如 statin ,-blocker,血管收缩素变换酶禁止者( ACEI )或血管收缩素 rece 在与在 6 个小时的控制组相比的 Tongxinluo 组有重要的圣片断恢复((-0.22????????????????????????????? 慰桴灯票楳汯杯捩污吗?? | ZHANG Hai-tao JIA Zhen-hua ZHANG Jian YE Zan-kai YANG Wei-xian TIAN Yue-qin JIA Xuan LI Wei WU Yi-ling YANG Yue-jin | 2010 | Chinese Medical Journal2010，，20： | 69 |
| 5 | Evaluation of the traditional Chinese medicine Shensongyangxin capsule on treating premature ventricular contractions: a randomized, double-blind, controlled multicenter trial显示文摘背景早熟的室的收缩(PVC ) 是治疗为掉进窘境的心律不齐的最普通的类型之一。以前的临床的申请证明繁体中文药 Shensongyangxin (SSYX ) 囊为 PVC 的治疗是有效的。这使随机化的临床的试用试图进一步在对待 PVC.Methods 上评估 SSYX 囊的功效和安全有经常的 PVC 与或没有器官的心疾病和正常心脏的功能的题目在学习被注册。主要端点是在有 SSYX 囊的八星期的药以后的 PVC 数字的变化。包括的第二等的端点与 PVC 和 SSYX 囊的安全评估有关的临床的症状变化。完全, 188 个 PVC 病人随机在非器官的心疾病 PVC 试用被注册并且口头上地拿了 SSYX 囊或类似物(三每天预定, 4 囊一次) 。671 个 PVC 病人的一个总数随机在器官的心疾病 PVC 试用被注册,并且口头上地拿了任何一个 SSYX 囊(三每天预定, 4 囊一次) 或 mexiletine 药片(三每天预定, 150 mg 时间) 。PVC 与 24 小时的 Holter 心电图被监视并且计算。在有 SSYX capsule.Results SSYX 囊的药显著地减少了前后,平淡的血,肝和肾功能被测试 PVC 数字并且在病人减轻了相关症状与或没有器官的心疾病。在非器官的心疾病组, SSYX 囊和安慰剂减少了从 12561.34 猠潣敲?的 PVC ???????鷓???鮰?钱?????????????????颓陎???讂??????鶝???????錄?吗??????疞????鮪鴿?铳?????????????? T ?? | ZOU Jian-gang ZHANG Jian JIA Zhen-hua CAO Ke-jiang | 2011 | Chinese Medical Journal2011，，1： | 70 |
| 6 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 7 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 8 | Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti- tumor effects in the digestive system显示文摘它广泛地被认出了那发炎,特别地长期的发炎,能增加癌症的风险并且发炎和癌症的同时的治疗可以生产优秀治疗学的效果。Berberine,从根茎 coptidis 孤立的碱,有宽广应用程序,特别地作为在有长历史的诊所的一个抗菌剂代理人。在过去的十年,许多报告证明了这个自然产品和它的衍生物对癌症和发炎举办高活动。在这评论,我们在在消化系统装饰 berberine 和它同样反煽动性的衍生物和反肿瘤代理人总结进展;我们也讨论他们的结构活动关系。这些数据应该作为有反发炎活动的新奇 anticancer 药为这个自然产品的发展是有用的。 | Kun ZOU Zhao LI Yong ZHANG Hao-yue ZHANG Bo LI Wei-liang ZHU Ji-ye SHI Qi JIA Yi-ming LI | 2017 | Acta Pharmacologica Sinica2017，38，2： | 58 |
| 9 | Adsorption removal of phosphate from aqueous solution by active red mud显示文摘红泥是氧化铝工业的浪费并且有是为阴离子污染物质的吸附的活跃部件的高 TiO2 和 Fe2O3 内容。在这研究,由热处理和酸热的处理激活的红泥的磷酸盐的举起是影响吸附的 investigated.Thefactors 也被调查。结果证明红泥样品与 0.25 mol/L HCl 在 80 ℃用酸热的方法对待因为 2 h 完成了最高的 phosphateremoval.For 激活热的红泥,更好为 2 h preformed 在 700 ℃加热的样品人另外的热处理。由激活的红泥的磷酸盐移动是显著地 pH 依赖者, 7 是的 andpH 为磷酸盐移动的最佳的 pH。吸附适合好的兰米尔等温线模型和酸热的激活的红泥的最大的吸附能力,激活的热取样分别地是 202.9 mgP/g 和 155.2 mgP/g。 | LIU Chang-jun LI Yan-zhong LUAN Zhao-kun CHEN Zhao-yang ZHANG Zhong-guo JIA Zhi-ping | 2007 | Journal of Environmental Sciences2007，19，10： | 47 |
| 10 | Comparison of endotracheal intubation with the Shikani Optical Stylet using the left molar approach and direct laryngoscopy显示文摘 | YAO Yun-tai JIA Nai-guang LI Cheng-hui ZHANG Ya-jun YIN Yi-qing | 2008 | Chinese Medical Journal2008，，14： | 41 |
| 11 | Immunoregulatory Effects of Ethyl-acetate Fraction of Extracts from Tetrastigma Hemsleyanum Diels et. Gilg on Immune Functions of ICR Mice显示文摘Objective To evaluate the effects of ethyl-acetate fraction (EAF) of extracts from Tetrastigma hemsleyanum Diels et. Gilg (TDG) on immune functions of ICR mice. Methods ICR mice were exposed to different doses of EAF for 15 or 30 days and then their immune functions were analyzed, including ConA-induced splenic lymphocyte transformation, SRBC- induced delayed type hypersensitivity response, serum hemolysin analysis, antibody-producing cells, peritoneal macrophage phagocytized chicken red blood cells, natural killer cell activity, and serum level of cytokines. Results EAF of extracts from TDG at different doses had various effects on immune functions of ICR mice. As compared with the controls, it increased the mouse spleen lymphocyte transformation induced by ConA, the left-hind voix pedis thickness and the number of plague forming cells (PFCs) at the dose of 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the ink clearance ability at the dose of 0.91 mg/mL, 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the phagocytosis index of mononuclear-macrophages and production of serum interferon-gamma (IFN-γ) at the dose of 5.48 mg/mL; and could promote the production of serum tumor necrosis factor-alpha (TNF-α) at the dose of 9.12 mg/mL. Conclusion EAF of extracts from TDG can regulate mouse immune functions in vivo. | CAI-JU XU GANG-QIANG DING JIAN-YUN FU JIA MENG RONG-HUA ZHANG XIAO-MING LOU | 2008 | Biomedical and Environmental Sciences2008，21，4： | 49 |
| 12 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 13 | PM_(2.5) in an industrial district of Zhengzhou,China:Chemical composition and source apportionment显示文摘郑州是在中国的一个发展中的城市,那被微粒物质的高水平重重地弄脏。在这研究,好微粒物质(PM2.5 ) 在在 2010 的郑州的一个工业区域为他们的化学作文(可溶的离子,元素,元素的碳(EC ) 和器官的碳(OC )) 镇定、分析。分别地, PM2.5 的平均集中与 175 g/m3 的年度一般水准是 181, 122, 186 和 211 g/m3 春天,夏天,秋天和冬季了,远超过美国国家空气质量标准(15 g/m3 ) 的 PM2.5 规定。在郑州的 PM2.5 的主导的部件是第二等的离子(硫酸盐和硝酸盐) 和碳部分。可溶的离子,全部的碳和元素分别地贡献了 41% PM2.5 质量, 13% 和 3% 。土壤灰尘,第二等的喷雾器和煤燃烧,各贡献大约 26% 全部的 PM2.5 质量, 24% 和 23% ,是 PM2.5 的主要来源,根据积极矩阵因式分解分析的结果。生物资源烧的混合来源,油燃烧和焚化贡献了 13% PM2.5。从车辆和工业产生的好微粒物质分别地贡献了大约 10% PM2.5 和 4% 。 | Ningbo Geng Jia Wang Yifei Xu Wending Zhang Chun Chen Ruiqin Zhang | 2013 | Particuology2013，11，1： | 46 |
| 14 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 15 | Anaerobic microbiologically influenced corrosion mechanisms interpreted using bioenergetics and bioelectrochemistry: A review显示文摘Microbiologically influenced corrosion(MIC) is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been proposed to explain MIC. In this review, the mechanisms of MIC are discussed using bioenergetics, microbial respiration types, and biofilm extracellular electron transfer(EET). Two main MIC types, namely EET-MIC and metabolite MIC(M-MIC), are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry. | Yingchao Li Dake Xu Changfeng Chen Xiaogang Li Ru Jia Dawei Zhang Wolfgang Sand Fuhui Wang Tingyue Cu | 2018 | Journal of Materials Science & Technology2018，34，10： | 43 |
| 16 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 17 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 18 | Probiotics in Helicobacter pylori eradication therapy: A systematic review and meta-analysis显示文摘AIM: To summarize the evidence from randomized controlled trials(RCTs) regarding the effect of probiotics by using a meta-analytic approach.METHODS: In July 2013, we searched PubM ed, EMBASE, Ovid, the Cochrane Library, and three Chinese databases(Chinese Biomedical Literature Database, Chinese Medical Current Content, and Chinese Scientific Journals database) to identify relevant RCTs.We included RCTs investigating the effect of a combination of probiotics and standard therapy(probiotics group) with standard therapy alone(control group).Risk ratios(RRs) were used to measure the effect of probiotics plus standard therapy on Helicobacter pylori(H.pylori) eradication rates, adverse events, and patient compliance using a random-effect model.RESULTS: We included data on 6997 participants from 45 RCTs, the overall eradication rates of the probiotic group and the control group were 82.31% and 72.08%, respectively.We noted that the use of probiotics plus standard therapy was associated with an increased eradication rate by per-protocol set analysis(RR = 1.11; 95%CI: 1.08-1.15; P < 0.001) or intention-totreat analysis(RR = 1.13; 95%CI: 1.10-1.16; P < 0.001).Furthermore, the incidence of adverse events was 21.44% in the probiotics group and 36.27% in the control group, and it was found that the probiotics plus standard therapy significantly reduced the risk of adverse events(RR = 0.59; 95%CI: 0.48-0.71; P < 0.001), which demonstrated a favorable effect of probiotics in reducing adverse events associated with H.pylori eradication therapy.The specific reduction in adverse events ranged from 30% to 59%, and this reduction was statistically significant.Finally, probiotics plus standard therapy had little or no effect on patient compliance(RR = 0.98; 95%CI: 0.68-1.39; P = 0.889).CONCLUSION: The use of probiotics plus standard therapy was associated with an increase in the H.pylori eradication rate, and a reduction in adverse events resulting from treatment in the general population.However, this therapy did not improve patient compliance. | Min-Min Zhang Wei Qian Ying-Yi Qin Jia He Yu-Hao Zhou | 2015 | World Journal of Gastroenterology2015，21，14： | 41 |
| 19 | De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis显示文摘AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver cirrhosis.METHODS:A total of 120 na ve patients with HBVrelated decompensated cirrhosis participated in this study.Sixty patients were treated with combined LAM and ADV therapy(LAM+ADV group),while the other60 were treated with ETV monotherapy(ETV group)for two years.Tests for liver and kidney function,alpha-fetoprotein,HBV serum markers,HBV DNA load,prothrombin time(PT),and ultrasonography or computed tomography scan of the liver were performed every1 to 3 mo.Repeated measure ANOVA and theχ2test were performed to compare the efficacy,side effects,and the cumulative survival rates at 48 and 96 wk.RESULTS:Forty-five patients in each group were observed for 96 wk.No significant differences in HBV DNA negative rates and alanine aminotransferase(ALT)normalization rates at weeks 48(χ2=2.12 and 2.88)and96(χ2=3.21 and 3.24)between the two groups were observed.Hepatitis B e antigen seroconversion rate in the LAM+ADV group at week 96 was significantly higher in the ETV group(43.5%vs 36.4%,χ2=4.09,P<0.05).Viral breakthrough occurred in 2 cases(4.4%)by week 48 and in 3 cases(6.7%)by week 96 in the LAM+ADV group,and no viral mutation was detected.In the ETV group,viral breakthrough occurred in 1 case(2.2%)at the end of week 96.An increase in albumin(F=18.9 and 17.3),decrease in total bilirubin and in ALT(F=16.5,17.1 and 23.7,24.8),reduced PT(F=22.7 and 24.5),and improved Child-Turcotte-Pugh and the model for end-stage liver disease scores(F=18.5,17.8,and 24.2,23.8)were observed in both groups.The cumulative rates of mortality and liver transplantation were 16.7%(10/60)and 18.3%(11/60)in the LAM+ADV and ETV groups,respectively.CONCLUSION:Both LAM+ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication,improve liver function,and decrease mortality. | Jiang-Shan Lian Lin-Yan Zeng Jian-Yang Chen Hong-Yu Jia Yi-Min Zhang Dai-Rong Xiang Liang Yu Jian-Hua Hu Ying-Feng Lu Ling Zheng Lan-Juan Li Yi-Da Yang | 2013 | World Journal of Gastroenterology2013，19，37： | 36 |
| 20 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
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