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| 1 | Effects of coal rank on physicochemical properties of coal and on methane adsorption显示文摘 | Yuanping Cheng Haina Jiang Xiaolei Zhang Jiaqing Cui Cheng Song Xuanliang Li | 2017 | International Journal of Coal Science & Technology2017，4，2： | 31 |
| 2 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 3 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 4 | Hybrid constructed wetlands for highly polluted river water treatment and comparison of surface-and subsurface-flow cells显示文摘A series of large pilot constructed wetland(CW) systems were constructed near the confluence of an urban stream to a larger river in Xi'an, a northwestern megacity in China, for treating polluted stream water before it entered the receiving water body. Each CW system is a combination of surfaceand subsurface-flow cells with local gravel, sand or slag as substrates and Phragmites australis and Typha orientalis as plants. During a one-year operation with an average surface loading of 0.053 m3/(m2·day), the overall COD, BOD, NH3-N, total nitrogen(TN) and total phosphorus(TP) removals were 72.7% ± 4.5%, 93.4% ± 2.1%, 54.0% ± 6.3%, 53.9% ± 6.0% and 69.4% ± 4.6%, respectively, which brought about an effective improvement of the river water quality. Surface-flow cells showed better NH3-N removal than their TN removal while subsurface-flow cells showed better TN removal than their NH3-N removal. Using local slag as the substrate, the organic and phosphorus removal could be much improved. Seasonal variation was also found in the removal of all the pollutants and autumn seemed to be the best season for pollutant removal due to the moderate water temperature and well grown plants in the CWs. | Yucong Zheng Xiaochang Wang Jiaqing Xiong Yongjun Liu Yaqian Zhao | 2014 | Journal of Environmental Sciences2014，26，4： | 13 |
| 5 | Oil–water pre-separation with a novel axial hydrocyclone显示文摘A novel hydrocyclone with guide vanes, named as axial hydrocyclone(AHC), is designed to tackle the problem of oil–water separation faced by most mature oilfields. Optimal design of the AHC is carried out by using numerical methods. The effects of guide vanes, cone angle, tapered angle and overflow pipe on the oil–water separation are discussed in this paper. The results show that a double swirling flow is generated in the tapered section where oil–water separation occurs. Both the cylindrical and the tapered section have important influences on AHC performance. On the basis of single factor results, response surface methodology is employed to optimize the AHC design. The experimental results indicate that the novel AHC has an excellent performance for the oil–water separation. | Meili Liu Jiaqing Chen Xiaolei Cai Yanhe Han Si Xiong | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 12 |
| 6 | Distinct sedimentary environments and their influences on carbonate reservoir evolution of the Lianglitag Formation in the Tarim Basin,Northwest China显示文摘The Upper Ordovician Lianglitag Formation carbonate rocks are important oil and gas reservoirs in the Tarim Basin,Northwest China,with obviously distinct reservoir properties among different oilfields.As a case area of the above carbonate reservoirs correlation,Tahe and Tazhong oilfields are chosen for the study through an integrated analysis of biostratigraphic isochronous framework,cores,thin sections,logs,and strontium isotopes.The research shows that the two areas were respectively attributed to different carbonate platforms during the Lianglitag Formation depositional phase.For the Lianglitag Formation,five fourth-order sequences may be divided in Tazhong,whereas only four fourth-order sequences are preserved in Tahe that correspond to the lower ones observed in Tazhong.The Lianglitag Formation carbonate platform in Tahe was characterized by ramp and/or weak rimmed types,with low depositional rates(37 μm/a),higher whole-rock clastic contents,and higher 87 Sr/86 Sr isotope ratios of carbonate matrix,showing relatively deep-water environment and evident terrigenous input for carbonate deposition.However,a strongly rimmed carbonate platform was developed in Tazhong,with high depositional rates of 250 m/a and less whole-rock clastic contents,indicating a high-energy depositional environment.Because of the sedimentary environment differences mentioned above,less high-energy facies but relatively intense syndepositional(early diagenetic) sea-water cementation of carbonates were developed in Tahe,and ubiquitous high-energy reef and shoal facies,with a frequent exposure to subaerial,and weak syndepositional sea-water cementation of carbonates in Tazhong.Therefore,fewer primary pores occurred in the Lianglitag Formation carbonate rocks of Tahe,whereas more primary pores were preserved in the same lithostratigraphic unit of the Tazhong(No.1 fault zone).Available high-energy reef-shoal facies and early diagenesis,with more primary pores preserved,provided a key material basis for the Lianglitag Formation carbonate reservoirs that largely occurred in Tazhong. | LIU JiaQing LI Zhong HUANG JunCou YANG Liu | 2012 | Science China Earth Sciences2012，55，10： | 11 |
| 7 | Aerodynamic simulation of evacuated tube maglev trains with different streamlined designs显示文摘Based on the Navier-Stokes (N-S) equations of incompressible viscous fluids and the standard k-ε turbulence model with assumptions of steady state and two dimensional conditions, a simulation of the aerodynamic drag on a maglev train in an evacuated tube was made with ANSYS/FLOTRAN software under different vacuum pressures, blockage ratios, and shapes of train head and tail. The pressure flow fields of the evacuated tube maglev train under different vacuum pressures were analyzed, and then compared under the same blockage ratio condition. The results show that the environmental pressure of 1 000 Pa in the tube is the best to achieve the effect of aerodynamic drag reduction, and there are no obvious differences in the aerodynamic drag reduction among different streamline head shapes. Overall, the bluntshape tail and the blockage ratio of 0.25 are more efficient for drag reduction of the train at the tube pressure of 1 000 Pa. | Xuyong CHEN Lifeng ZHAO Jiaqing MA Yuansen LIU | 2012 | Journal of Modern Transportation2012，20，2： | 11 |
| 8 | Research on the reconstruction method of porous media using multiple-point geostatistics显示文摘The pore structural characteristics have been the key to the studies on the mechanisms of fluids flow in porous media. With the development of experimental technology, the modern high-resolution equipments are capable of capturing pore structure images with a resolution of microns. But so far only 3D volume data of millimeter-scale rock samples can be obtained losslessly. It is necessary to explore the way of virtually reconstructing larger volume digital samples of porous media with the representative structural characteristics of the pore space. This paper proposes a reconstruction method of porous media using the structural characteristics captured by the data templates of multiple-point geostatistics. In this method, the probability of each structural characteristic of a pore space is acquired first, and then these characteristics are reproduced according to the probabilities to present the real structural characteristics in the reconstructed images. Our experimental results have shown that: (i) the deviation of LBM computed permeability respectively on the virtually reconstructed sandstone and the original sample is less than 1.2%; (ii) the reconstructed sandstone and the original sample have similar structural characteristics demonstrated by the variogram curves. | ZHANG Ting 1,2,3, LI DaoLun 1,2 , LU DeTang 1,2 & YANG JiaQing 1,2 1 Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, China 2 Research Center of Oil and Natural Gas, University of Science and Technology of China, Hefei 230027, China 3 The 28th Research Institute, China Electronics Technology Group Corporation, Nanjing, 210007, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 10 |
| 9 | The approach to calculate the aerodynamic drag of maglev train in the evacuated tube显示文摘In order to study the relationships between the aerodynamic drag of maglev and other factors in the evacuated tube,the formula of aerodynamic drag was deduced based on the basic equations of aerodynamics and then the calculated result was confirmed at a low speed on an experimental system developed by Superconductivity and New Energy R&D Center of South Jiaotong University.With regard to this system a high temperature superconducting magnetic levitation vehicle was motivated by a linear induction motor(LIM) fixed on the permanent magnetic guideway.When the vehicle reached an expected speed,the LIM was stopped.Then the damped speed was recorded and used to calculate the experimental drag.The two results show the approximately same relationship between the aerodynamic drag on the maglev and the other factors such as the pressure in the tube,the velocity of the maglev and the blockage ratio.Thus,the pressure,the velocity,and the blockage ratio are viewed as the three important factors that contribute to the energy loss in the evacuated tube transportation. | Jiaqing Ma Dajing Zhou Lifeng Zhao Yong Zhang Yong Zhao | 2013 | Journal of Modern Transportation2013，21，3： | 10 |
| 10 | Modifi cation of wheat bran insoluble and soluble dietary fibers with snail enzyme显示文摘Insoluble dietary fiber(IDF)and soluble dietary fiber(SDF)extracted from wheat bran were modifi ed by snail enzyme and their physicochemical properties(water retention capacity and oil retention capacity),functional properties(cholesterol adsorption capacity,glucose adsorption capacity and antioxidant activity)and structural characterizations were evaluated.The results showed that snail enzyme modification led to the significant increase in oil retention capacity of IDF,glucose adsorption capacity and cholesterol adsorption capacity of IDF and SDF.Enzymatic modification also markedly improved the DPPH radical scavenging capacity and reducing power of IDF and SDF.Meanwhile,scanning electron microscopy(SEM)analysis indicated the microstructures of IDF and SDF powders were signifi cantly changed.Fourier transfer-infrared spectrometry(FT-IR)showed that snail enzyme modifi cation could degrade the part of cellulose and hemicellulose of IDF and SDF.All these improved physicochemical and functional properties of IDF and SDF might depend on their structural changes.It suggested that snail enzyme modifi cation could effectively improve physicochemical and functional properties of IDF and SDF from wheat bran. | Xin Liu Keke Suo Pei Wang Xue Li Limin Hao Jiaqing Zhu Juanjuan Yi Qiaozhen Kang Jinyong Huang Jike Lu | 2021 | Food Science and Human Wellness2021，10，3： | 10 |
| 11 | CN-DBpedia2: An Extraction and Verification Framework for Enriching Chinese Encyclopedia Knowledge Base显示文摘Knowledge base plays an important role in machine understanding and has been widely used in various applications, such as search engine, recommendation system and question answering. However, most knowledge bases are incomplete, which can cause many downstream applications to perform poorly because they cannot find the corresponding facts in the knowledge bases. In this paper, we propose an extraction and verification framework to enrich the knowledge bases. Specifically, based on the existing knowledge base, we first extract new facts from the description texts of entities. But not all newly-formed facts can be added directly to the knowledge base because the errors might be involved by the extraction. Then we propose a novel crowd-sourcing based verification step to verify the candidate facts. Finally, we apply this framework to the existing knowledge base CN-DBpedia and construct a new version of knowledge base CN-DBpedia2, which additionally contains the high confidence facts extracted from the description texts of entities. | Bo Xu Jiaqing Liang Chenhao Xie Bin Liang Lihan Chen Yanghua Xiao | 2019 | Data Intelligence2019，1，3： | 9 |
| 12 | A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation显示文摘AIM: To evaluate the efficacy and safety of tegaserod, 6 mg twice daily (b.i.d.), in men and women with chronic constipation (CC) from China. METHODS: This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatment-free baseline period, patients were randomized to receive either tegaserod (6 mg b.i.d.) or placebo (b.i.d.) for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements (CSBMs) during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients’ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events (AEs).RESULTS: A total of 607 patients were randomized to receive either tegaserod (n = 304) or placebo (n = 303). Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo (1.39 vs 0.91, P = 0.0002). A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 (47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018) and for the absolute number of ≥ 3 CSBMs/wk over wk 1-4 (25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021). Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod (3.6%) compared with placebo (1.7%).CONCLUSION: Tegaserod treatment improved multiple symptoms of CC and was associated with a favorable safety profile. | San-Ren Lin Mei-Yun Ke Jin-Yan Luo Yao-Zong Yuan Ji-Yao Wang Shelley diTommaso Verena Walter Jiaqing Huang | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 13 | Epidemiology of urticaria in China:a population-based study显示文摘Background:Urticaria is a common skin disease characterized by episodes of wheals,and it has a negative effect on patients’quality of life.Large-scale population-based epidemiological studies of urticaria are scarce in China.The aim of this survey was to determine the prevalence,clinical forms,and risk factors of urticaria in the Chinese population.Methods:This survey was conducted in 35 cities from 31 provinces,autonomous regions,and municipalities of China.Two to three communities in each city were selected in this investigation.Participants completed questionnaires and received dermatological examinations.We analyzed the prevalence,clinical forms,and risk factors of urticaria.Results:In total,44,875 questionnaires were distributed and 41,041 valid questionnaires were collected(17,563 male and 23,478 female participants).The lifetime prevalence of urticaria was 7.30%,with 8.26%in female and 6.34%in male individuals(P<0.05).The point prevalence of urticaria was 0.75%,with 0.79%in female and 0.71%in male individuals(P<0.05).Concomitant angioedema was found in 6.16%of patients.Adults had a higher prevalence of urticaria than adolescents and children.Living in urban areas,exposure to pollutants,an anxious or depressed psychological status,a personal and family history of allergy,thyroid diseases,and Helicobacter pylori infection were associated with a higher prevalence of urticaria.Smoking was correlated with a reduced risk of urticaria.Conclusion:This study demonstrated that the lifetime prevalence of urticaria was 7.30%and the point prevalence was 0.75%in the Chinese population;women had a higher prevalence of urticaria than men.Various factors were correlated with urticaria. | Jiaqing Li Dandan Mao Shuoshuo Liu Ping Liu Jing Tian Chenhong Xue Xiaojing Liu Ruiqun Qi Bingxue Bai Jianjun Nie Siqi Ye Yu Wang Yuye Li Qing Sun Juan Tao Shuping Guo Hong Fang Jianqin Wang Qiri Mu Quanzhong Liu Yan Ding Jianzhong Zhang | 2022 | Chinese Medical Journal2022，，11： | 6 |
| 14 | Recent advancements in optical microstructure fabrication through glass molding process显示文摘 | Tianfeng ZHOU Xiaohua LIU Zhiqiang LIANG Yang LIU Jiaqing XIE Xibin WANG | 2017 | Frontiers of Mechanical Engineering2017，12，1： | 6 |
| 15 | Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration显示文摘Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue engineering.Designing and fabricating hydrogels with high adhesive strength,stability and regeneration potential are major challenges to be overcome.This study fabricated injectable adhesive hyaluronic acid(HA)hydrogel modified by aldehyde groups and methacrylate(AHAMA)on the polysaccharide backbone with multiple anchoring mechanisms(amide bond through the dynamic Schiff base reaction,hydrogen bond and physical interpenetration).AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment(at least 7 days),together with higher adhesive strength(43 KPa to skin and 52 KPa to glass),as compared to commercial fibrin glue(nearly 10 KPa)and HAMA hydrogel(nearly 20 KPa).The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared in situ.In vitro cell culture experiments showed that AHAMA hydrogel could enhance proliferation(1.2-folds after 3 days)and migration(1.5-folds after 12 h)of bone marrow stem cells(BMSCs),as compared to cells cultured in a culture dish.Furthermore,in a rat osteochondral defect model,implanted AHAMA hydrogel significantly promoted integration between neo-cartilage and host tissues,and significantly improved cartilage regeneration(modified O’Driscoll histological scores of 16.0±4.1 and 18.3±4.6 after 4 and 12-weeks of post-implantation in AHAMA groups respectively,12.0±2.7 and 12.2±2.8 respectively in HAMA groups,9.8±2.4 and 11.5±2.1 respectively in untreated groups).Hence,AHAMA hydrogel is a promising adhesive biomaterial for clinical cartilage regeneration and other biomedical applications. | Jiaqing Chen Jiabei Yang Li Wang Xuewei Zhang Boon Chin Heng Dong-An Wang Zigang Ge | 2021 | Bioactive Materials2021，6，6： | 6 |
| 16 | Correlation-enhanced electron-phonon coupling for accurate evaluation of the superconducting transition temperature in bulk FeSe显示文摘It has been widely recognized that,based on standard density functional theory calculations of the electron-phonon coupling,the superconducting transition temperature(T_(c))in bulk FeSe is exceptionally low(almost 0 K)within the Bardeen-Cooper-Schrieffer formalism.Yet the experimentally observed T_(c)is much higher(∼10 K),and the underlying physical origin remains to be fully explored,especially at the quantitative level.Here we present the first accurate determination of T_(c)in FeSe where the correlation-enhanced electron-phonon coupling is treated within first-principles dynamical mean-field theory.Our studies treat both the multiple electronic bands across the Fermi level and phononic bands,and reveal that all the optical phonon modes are effectively coupled with the conduction electrons,including the important contributions of a single breathing mode as established by previ-ous experiments.Accordingly,each of those phonon modes contributes pronouncedly to the electron pairing,and the resultant T_(c)is drastically enhanced to the experimentally observed range.The approach developed here should be broadly applicable to other superconducting systems where correlation-enhanced electron-phonon coupling plays an important role. | Wenjun Ding Yilin Wang Tong Wei Jiaqing Gao Ping Cui Zhenyu Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 5 |
| 17 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 18 | Synthesis of Mg-Al-carbonate layered double hydroxide by an atom-economic reaction显示文摘A clean method for preparing layered double hydroxides (LDHs) has been developed, featured by using the hydroxides of two different metals as starting materials by atom-economic reactions. The reactions were carried out under hydrothermal conditions in either a high pressure autoclave or a microwave digester. The compositions, structural parameters and thermal behavior of the resulting LDHs are very similar to those of materials produced by using the separate nucleation and aging steps (SNAS) method. The major advantage of the new method is that no by-product is produced, so that filtration and washing processes are unnecessary. The consequent reduction in water consumption is beneficial to the environment. | Xiangyu Xu Dianqing Li Jiaqing Song Yanjun Lin Zhi Lv Min Wei Xue Duan | 2010 | Particuology2010，8，3： | 4 |
| 19 | Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan显示文摘Pharmacometabolomics has been already successfully used in toxicity prediction for one specific adverse effect. However in clinical practice, two or more different toxicities are always accompanied with each other, which puts forward new challenges for pharmacometabolomics. Gastrointestinal toxicity and myelosuppression are two major adverse effects induced by Irinotecan(CPT-11),and often show large individual differences. In the current study, a pharmacometabolomic study was performed to screen the exclusive biomarkers in predose serums which could predict late-onset diarrhea and myelosuppression of CPT-11 simultaneously. The severity and sensitivity differences in gastrointestinal toxicity and myelosuppression were judged by delayed-onset diarrhea symptoms, histopathology examination, relative cytokines and blood cell counts. Mass spectrometry-based non-targeted and targeted metabolomics were conducted in sequence to dissect metabolite signatures in predose serums. Eventually,two groups of metabolites were screened out as predictors for individual differences in late-onset diarrhea and myelosuppression using binary logistic regression, respectively. This result was compared with existing predictors and validated by another independent external validation set. Our study indicates the prediction of toxicity could be possible upon predose metabolic profile. Pharmacometabolomics can be a potentially useful tool for complicating toxicity prediction. Our findings also provide a new insight into CPT-11 precision medicine. | Yiqiao Gao Wei Li Jiaqing Chen Xu Wang Yingtong Lv Yin Huang Zunjian Zhang Fengguo Xu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 4 |
| 20 | Doubly selective fading channel estimation in MIMO OFDM systems显示文摘High data transmission rates and high mobility give rise to time- and frequency-selectivity in wireless communication channels. This paper investigated time and frequency doubly selective channel estimation using pilot tones among Multi-Input Multi-Output (MIMO) orthogonal frequency division multiplexing (OFDM). Firstly, a complex exponential basis expansion channel model (BECM) was introduced to represent doubly selective channel during an OFDM symbol period; then, based on BECM, an effective MIMO-OFDM doubly selective channel estimation method was presented; finally, the optimality in designing pilot tones parameters was done according to the minimization of channel estimation MSE, mainly including the number, the placement and the structure of pilot tones. Simulation results show that the proposed estimation method has good performance in doubly selective channel scenarios and confirms the theoretical analysis findings. | YU Xiaoyan WANG Jiaqing YANG Luxi HE Zhenya | 2005 | Science in China(Series F)2005，48，6： | 4 |
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