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您的检索式：作者名="Jiahan Ding"
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| 1 | Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer:the FUTURE trial显示文摘Triple-negative breast cancer(TNBC)is a highly heterogeneous disease,and molecular subtyping may result in improved diagnostic precision and targeted therapies.Our previous study classified TNBCs into four subtypes with putative therapeutic targets.Here,we conducted the FUTURE trial(ClinicalTrials.gov identifer:NCT03805399),a phaseⅠb/Ⅱsubtyping-based and genomic biomarker-guided umbrella trial,to evaluate the efficacy of these targets.Patients with refractory metastatic TNBC were enrolled and stratifed by TNBC subtypes and genomic biomarkers,and assigned to one of these seven arms:(A)pyrotinib with capecitabine,(B)androgen receptor inhibitor with CDK4/6 inhibitor,(C)anti PD-1 with nab-paclitaxel,(D)PARP inhibitor included,(E)and(F)anti-VEGFR included,or(G)mTOR inhibitor with nab paclitaxel.The primary end point was the objective response rate(ORR).We enrolled 69 refractory metastatic TNBC patients with a median of three previous lines of therapy(range,1-8).Objective response was achieved in 20(29.0%,95%confidence interval(CI):18.7%-41.2%)of the 69 intention-to-treat(ITT)patients.Our results showed that immunotherapy(arm C),in particular,achieved the highest ORR(52.6%,95%CI:28.9%-75.6%)in the ITT population.Arm E demonstrated favorable ORR(26.1%,95%C:10.2%-48.4%in the ITT population)but with more high grade(23)adverse events.Somatic mutations of TOP2A and CD8 immunohistochemical score may have the potential to predict immunotherapy response in the immunomodulatory subtype of TNBC.In conclusion,the phaseⅠb/ⅡFUTURE trial suggested a new concept for TNBC treatment,demonstrating the clinical beneft of subtyping-based targeted therapy for refractory metastatic TNBC. | Yi-Zhou Jiang Yin Liu Yi Xiao Xin Hu Lin Jiang Wen-ia Zuo Ding Ma Jiahan Ding Xiaoyu Zhu Jianjun Zou Claire Verschraegen Daniel G.Stover Virginia Kaklamani Zhong-Hua Wang Zhi-Ming Shao | 2021 | Cell Research2021，31，2： | 37 |
| 2 | Mobile power generation system based on biomass gasifcation显示文摘Disaster-hit and/or un-electrifed remote areas usually have electricity accessibility issues and an abundance of plant-derived debris and wood from destroyed wooden structures;this can be potentially addressed by employing a decentralized ultrasmall biomass-fed gasifcation power generating system.This paper presents an assessment of the technical viability of an ultra-small gasifcation system that utilizes densifed carbonized wood pellets/briquettes.The setup was run continuously for 100 h.A variety of biomass was densifed and carbonized by harnessing fugitive heat sources before charging into the reactor.Carbonized briquettes and furnished blends exhibited inferior gasifcation performance compared to the carbonized pellets.In the absence of tar blockage problems,steady-state conditions were achieved when pre-treated feedstock was used.Under steady-state conditions for carbonized pellets gasifcation operated at an equivalence ratio of 0.32,cold gas efciency and carbon conversion achieved 49.2%and 70.5%,respectively.Overall efciency and maximum power output of 20.3%and 21 kW were realised,respectively.It was found that the system could keep stable while the low heating valve of syngas was over 4 MJ/m^(3)on condition that avoiding tar blocking issues.The results indicate that the proposed compact ultra-small power generation system is a technically feasible approach to remedy power shortage challenge.In addition,process simulation considering carbonized wood gasifcation combined power generation was formulated to produce syngas and electricity.Woody pellets with the fow rate of 20 kg/h could generate a 15.18 kW power at the air fow rate of 40 Nm^(3)/h,which is in a good agreement with 15 kW in the 100 h operation.It is indicated that the gasifcation combined power generation cycle simulated by Aspen simulator could achieve reliable data to assist the complicated experiment operation. | Lu Ding Mingming Yang Kai Dong Dai‑Viet N.Vo Douglas Hungwe Jiahan Ye Alexander Ryzhkov Kunio Yoshikawa | 2022 | International Journal of Coal Science & Technology2022，9，3： | 0 |
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