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| 1 | NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis显示文摘Plants are highly susceptible to abiotic stresses,particularly heat stress during the reproductive stage.However,the specific molecular mechanisms underlying this sensitivity remain largely unknown.In the current study,we demonstrate that the Nuclear Transcription Factor,X-box Binding Protein 1-Like 1(NFXL1),directly regulates the expression of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A(DREB2A),which is crucial for reproductive thermotolerance in Arabidopsis.NFXL1 is upregulated by heat stress,and its mutation leads to a reduction in silique length(seed number)under heat stress conditions.RNA-Seq analysis reveals that NFXL1 has a global impact on the expression of heat stress responsive genes,including DREB2A,Heat Shock Factor A3(HSFA3)and Heat Shock Protein 17.6(HSP17.6)in flower buds.Interestingly,NFXL1 is enriched in the promoter region of DREB2A,but not of either HSFA3 or HSP17.6.Further experiments using electrophoretic mobility shift assay have confirmed that NFXL1 directly binds to the DNA fragment derived from the DREB2A promoter.Moreover,effector-reporter assays have shown that NFXL1 activates the DREB2A promoter.The DREB2A mutants are also heat stress sensitive at the reproductive stage,and DEREB2A is epistatic to NFXL1 in regulating thermotolerance in flower buds.It is known that HSFA3,a direct target of DREB2A,regulates the expression of heat shock proteins genes under heat stress conditions.Thus,our findings establish NFXL1 as a critical upstream regulator of DREB2A in the transcriptional cassette responsible for heat stress responses required for reproductive thermotolerance in Arabidopsis. | Qiao‐Yun Zhu Lin‐Lin Zhang Jian‐Xiang Liu | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 2 | Molecular basis of protein S deficiency in China显示文摘 | Liang Tang Xiao‐Rong Jian Naotaka Hamasaki Tao Guo Hua‐Fang Wang Xuan Lu Qing‐Yun Wang Yu Hu | 2013 | Am J Hematol2013，，10： | 1 |
| 3 | A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants显示文摘 | Yun Chen Shugeng Cao Yunrong Chai Jon Clardy Roberto Kolter Jian‐hua Guo Richard Losick | 2012 | Molecular Microbiology2012，，3： | 1 |
| 4 | Biocontrol of tomato wilt disease by B acillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation显示文摘 | Yun Chen Fang Yan Yunrong Chai Hongxia Liu Roberto Kolter Richard Losick Jian‐hua Guo | 2012 | Environ Microbiol2012，，3： | 1 |
| 5 | Overexpression of BMI ‐1 is associated with poor prognosis in cervical cancer显示文摘 | Yong‐Qing Tong Bei Liu Hong‐Yun Zheng Yu‐Juan He Jian Gu Feng Li Yan Li | 2012 | Asia‐Pac J Clin Oncol2012，，4： | 1 |
| 6 | Overexpression of BMI ‐1 is associated with poor prognosis in cervical cancer显示文摘 | Yong‐Qing Tong Bei Liu Hong‐Yun Zheng Yu‐Juan He Jian Gu Feng Li Yan Li | 2012 | Asia‐Pac J Clin Oncol2012，，4： | 1 |
| 7 | Epidemiological survey and risk factor analysis of fatty liver disease of adult residents, B eijing, C hina显示文摘 | Jie Yan Wen Xie Wei‐ni Ou Hong Zhao Su‐yun Wang Jian‐hui Wang Qi Wang Yu‐ying Yang Xin Feng Jun Cheng | 2013 | J Gastroenterol Hepatol2013，，10： | 3 |
| 8 | Effects of MicroRNA‐29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma显示文摘 | Yujuan Xiong Jian‐Hong Fang Jing‐Ping Yun Jine Yang Ying Zhang Wei‐Hua Jia Shi‐Mei Zhuang | 2010 | Hepatology2010，，3： | 2 |
| 9 | Tracing type 1 diabetic T ibet miniature pig’s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging (1型糖尿病西藏小型猪骨髓间充质干细胞体外磁共振成像示踪)显示文摘 | Kuan‐Xiao Tang Jin‐Hua Yan Yun‐Feng Shen Bao‐Ying Li Ying‐Ming Chen Da‐Yue Liu De‐Dong Ma Jie Li Hua Liang Jian‐Ping Weng | 2014 | Journal of Diabetes2014，，： | 1 |
| 10 | Flower development of Phalaenopsis orchid involves functionally divergent SEPALLATA ‐like genes显示文摘 | Zhao‐Jun Pan You‐Yi Chen Jian‐Syun Du Yun‐Yu Chen Mei‐Chu Chung Wen‐Chieh Tsai Chun‐Neng Wang Hong‐Hwa Chen | 2014 | New Phytol2014，，： | 1 |
| 11 | Dexamethasone in outcome of patients with hepatitis B virus‐related acute‐on‐chronic liver failure显示文摘 | Jun‐Feng Chen Ke‐Wei Wang Shao‐Quan Zhang Zi‐Ying Lei Jun‐Qiang Xie Jian‐Yun Zhu Wei‐Zhen Weng Zhi‐Liang Gao Bing‐Liang Lin | 2014 | J Gastroenterol Hepatol2014，，4： | 1 |
| 12 | Overexpression of galectin‐1 is associated with poor prognosis in human hepatocellular carcinoma following resection显示文摘 | Han Wu Pei Chen Rui Liao Yi‐Wei Li Yong Yi Jia‐Xing Wang Tai‐Wei Sun Jian Zhou Ying‐Hong Shi Xin‐Rong Yang Jian‐Jun Jin Yun‐Feng Cheng Jia Fan Shuang‐Jian Qiu | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 1 |
| 13 | Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis显示文摘 | Jiao Qin Yan‐yun Xie Ling Huang Qiong‐jing Yuan Wen‐Juan Mei Xiang‐ning Yuan Gao‐yun Hu Guang‐jie Cheng Li‐jian Tao Zhang‐zhe Peng | 2013 | Nephrology2013，，10： | 1 |
| 14 | Polymorphisms in the coding region of X‐ray repair complementing group 4 and aflatoxin B1‐related hepatocellular carcinoma显示文摘 | Xi‐Dai Long Jin‐Guang Yao Zhi Zeng Yun Ma Xiao‐Ying Huang Zhong‐Hua Wei Min Liu Jian‐Jun Zhang Feng Xue Bo Zhai Qiang Xia | 2013 | Hepatology2013，，1： | 1 |
| 15 | Intratumoral regulatory T cells with higher prevalence and more suppressive activity in hepatocellular carcinoma patients显示文摘 | Han Wu Pei Chen Rui Liao Yi‐Wei Li Yong Yi Jia‐Xing Wang Xiao‐Yan Cai Hong‐Wei He Jian‐Jun Jin Yun‐Feng Cheng Jia Fan Jian Sun Shuang‐Jian Qiu | 2013 | J Gastroenterol Hepatol2013，，9： | 1 |
| 16 | Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis显示文摘 | Jiao Qin Yan‐yun Xie Ling Huang Qiong‐jing Yuan Wen‐Juan Mei Xiang‐ning Yuan Gao‐yun Hu Guang‐jie Cheng Li‐jian Tao Zhang‐zhe Peng | 2013 | Nephrology2013，，10： | 1 |
| 17 | Meserine, a Novel Carbamate AC hE Inhibitor, Ameliorates Scopolamine‐Induced Dementia and Alleviates Amyloidogenesis of APP / PS 1 Transgenic Mice显示文摘 | Bi‐Yun Shao Zheng Xia Qiong Xie Xin‐Xing Ge Wei‐Wei Zhang Jian Sun Pan Jiang Hao Wang Wei‐Dong Le Zhui‐Bai Qiu Yang Lu Hong‐Zhuan Chen | 2014 | CNS Neurosci Ther2014，，： | 1 |
| 18 | Imbalance of interleukin‐17‐producing CD 4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus‐related acute‐on‐chronic liver failure显示文摘 | Geng‐Lin Zhang Dong‐Ying Xie Bing‐Liang Lin Chan Xie Yi‐Nong Ye Liang Peng Shao‐Quan Zhang Yu‐Feng Zhang Qing Lai Jian‐Yun Zhu Ying Zhang Yang‐Su Huang Zhao‐Xia Hu Zhi‐Liang Gao | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
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