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| 1 | Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97显示文摘ALM To establish clone cells with different metastatic potential for the study of metastasis-related mechanisms. METHODS Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97. andbiological characteristics of the target clones selected by in vivo screening were studied.``RESULTS Two clones with high MHCC97-H and IowMHCC9--L1 metastatic potential were isolated from theparent cell line. Compared with MHCC97-L. MHCC97-H hadsmaller cell size average cell diameter 43 um vs 50 μmand faster in vitro and in vivo growth rate tumor celldoubling time was 34.2 h vs 60.0 h. The main ranges ofchromosomes were 5.5 58 in MHCC97-H and 57 62 inMHCC97-L. Boyden chamber in vitro invasion assay demonstrated that the number of penetrating cells through the artificial basement membrane was 137.5 - 11 .0) cellsfield for MHC_C99--H vs 17.7 - 6.3) field for MHCC97-L.The proportions of cells in GO Gl phase. S phase, and G_ M phase for MHCC97-H MHCC97-L were 0.56 6.65.0.28 0.25 and 0.l6 0.10, respectively, as measured by flow cytometry. The serum AFP levels in nude mice 5 wk after orthotopic implantation of tumor tissue were ( 24666 μg. L for MHCC97-H and (91- 66) μg' L 1 for MHCC97L. The pulmonary metastatic rate was 100% (10-10) vs40% 4- 10).``CONCLUSION Two clones of the same genetic background but with different biological behaviors were established, which could be valuable models for investigation on HCC metastasis. | Yan Li Zhao-You Tang Sheng-Long Ye Yin-Kun Liu Jie Chen Qiong Xue Jun Chen Dong-Mei Gao Wei-Hua Bao Liver Cancer Institute and Zhongshan Hospital of Fudan University (Former Liver Cancer Institute of Shanghai Medical University),Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 111 |
| 2 | New proofs of the recent climate warming over the Tibetan Plateau as a result of the increasing greenhouse gases emissions显示文摘A striking climate warming over the Ti- betan Plateau during the last decades has been re- vealed by many studies, but evidence linking it to human activity is insufficient. By using historical ob- servations, here we show that the in situ climate warming is accompanied by a distinct decreasing trend of the diurnal range of surface air temperature. The ERA40 reanalysis further indicates that there seems to be a coherent warming trend near the tro- popause but a cooling trend in the lower stratosphere. Moreover, all these features can be reproduced in two coupled climate models forced by observed CO2 concentration of the 20th century but cannot be pro- duced by the fixed external conditions before the industrial revolution. These suggest that the recent climate warming over the Tibetan Plateau primarily results from the increasing anthropogenic green- house gases emissions, and impacts of the increased greenhouse gases emissions upon the climate change in the plateau are probably more serious than the rest of the world. | DUAN Anmin WU Guoxiong ZHANG Qiong LIU Yimin | 2006 | Chinese Science Bulletin2006，51，11： | 51 |
| 3 | Synthesis and paste properties of octenyl succinic anhydride modified early Indica rice starch显示文摘Octenyl succinic anhydride (OSA) modified early Indica rice starch was prepared in aqueous slurry systems using response surface methodology. The paste properties of the OSA starch were also investigated. Results indicated that the suitable parameters for the preparation of OSA starch from early Indica rice starch were as follows: reaction period 4 h, reaction tem- perature 33.4 °C, pH of reaction system 8.4, concentration of starch slurry 36.8% (in proportion to water, w/w), amount of OSA 3% (in proportion to starch, w/w). The degree of substitution was 0.0188 and the reaction efficiency was 81.0%. The results of paste properties showed that with increased OSA modification, the starch derivatives had higher paste clarity, decreased retro- gradation and better freeze-thaw stability. | SONG Xiao-yan CHEN Qi-he RUAN Hui HE Guo-qing XU Qiong | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 51 |
| 4 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 5 | Shear-wave splitting beneath Yunnan area of Southwest China显示文摘Systematic analyses of seismic data recorded by the Yunnan regional seismograph network reveal significant crustal and upper mantle anisotropy.Splitting of the S phase of local earthquakes and teleseismic SKS,PKS,and SKKS phases indicates time-delays from 1.60 ms/km to 2.30 ms/km in the crust,and from 0.55 s to 1.65 s in the upper mantle which corresponds to an anisotropic layer with a thickness about between 55-165 km.The polarization orientations of fast shear waves in the crust are complicated with a predominantly north-south direction,and the mantle anisotropy has a nearly west-east direction.Our results show different deformation styles and mechanisms exist between the crust and upper mantle. | Yutao Shi Yuan Gao Youjin Su Qiong Wang | 2012 | Earthquake Science2012，25，1： | 46 |
| 6 | Oral cancer incidence and mortality in China, 2011显示文摘Objective: To descript the incidence and mortality rates of oral cancer among Chinese population in 2011, and provide valuable data for oral cancer prevention and research.Methods: Data from 177 population-based cancer registries distributed in 28 provinces were accepted for this study after evaluation based on quality control criteria, covering a total of 175,310,169 populations and accounting for 13.01% of the overall national population in 2011. Incidence and mortality rates were calculated by area, gender and age groups. The numbers of new cases and deaths were estimated using the 5-year age-specific cancer incidence/mortality rates and the corresponding populations. The Chinese population in 2000 and World Segi's population were used for age-standardized rates.Results: The estimate of new cases diagnosed with oral cancer was 39,450 including 26,160 males and 13,290 females. The overall crude incidence rate for oral cancer was 2.93/100,000. The age-standardized rates by China(ASRCN) population and by World population(ASRwld) were 2.22/100,000 and 2.17/100,000, respectively. Among subjects aged 0-74 years, the cumulative incidence rate was 0.25%. The estimated number of oral cancer deaths of China in 2011 was 16,933, including 11,794 males and 5,139 females. The overall crude mortality rate was 1.26/100,000, accounting for 0.80% of all cancer deaths. The ASRCN and ASRwld for mortality were 0.90/100,000 and 0.89/100,000, respectively. Among subjects aged 0-74 years, the cumulative mortality rate was 0.10%. The incidence and mortality rates of oral cancer were much higher in males and urban areas than in females and rural areas. In addition, the incidence and mortality rates were increased by the raising of ages.Conclusions: Results in the study may have important roles for oral cancer prevention and research. Although oral cancer burden of China is not high, we must pay attention to this malignancy as well. In addition, further researches need to be done for primary and secondary prevention research of oral cancer, especially for the high risk population. | Shao-Kai Zhang Rongshou Zheng Qiong Chen Siwei Zhang Xibin Sun Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 44 |
| 7 | Studies on Temporal and Spatial Variations of Phytoplankton in Lake Chaohu显示文摘这研究的目的是在乔胡湖,描述浮游植物集合的时间、空间的变化,并且讨论位于这些变化下面的可能的机制在中国的一个大浅发育营养正常促进剂湖,与 cyanobacteria 上的强调。191 浮游植物种类的一个总数被识别,在哪个评价的绿色植物(101 ) 之中第一,由 Cyanophytes (46 ) 和 Bacillariophytes (28 ) 列在后面。平均在全部湖上,最大的全部的海藻的生物资源在 11 月与最小(5.05 mg/l ) 出现在 6 月(19.70 mg/l ) 。以累年平均生物资源, cyanobacteria 贡献了 45.43% 总计海藻的生物资源,跟随的 byChlorophytes (27.14%) ,和 Bacillariophytes (20.6%) 。当硝酸盐(NO3-N ) 和集中顺便坐坐的铵(NH4-N ) 跳时,修理氮的 cyanobacterium (淡水藻类的一种) 快速开发了 dranked 第一以在夏天的生物资源。zooplanktivorous 鱼和小甲壳纲的动物浮游动物的那优势赞成了发展,是可能的不可食细丝状或殖民地形成 cyanobacteria。在整个所有季节的 cyanobacteria 的坚持的优势可以在乔胡湖显示对超营养作用的浮游植物的反应的一个新趋势…… | Dao-Gui Deng Ping Xie Qiong Zhou Hua Yang Long-Gen Guo | 2007 | Journal of Integrative Plant Biology2007，49，4： | 36 |
| 8 | Effects of the tyrosine protein kinase inhibitor genistein on the proliferation,activation of cultured rat hepatic stellate cells显示文摘AIM: Hepatic stellate cell (HSC) plays a pivotal role inliver fibrosis and is considered as the therapeutic targetfor the treatment of hepatic fibrosis. Tyrosine proteinkinase plays an important role in the proliferation,activation of HSC. The purpose of the study is toinvestigate the effects of the tyrosine protein kinaseinhibitor genistein onthe proliferation and activationof cultured rat HscMETHODS: Rat HSC were isolated from Wistar rats by insitu perfusion of collagenase and pronase and single-stepdensity Nycodenz gradient. Culture-activated HSC wereserum-starved and incubated with 10-3 to 10-5 mol/Lconcentration of genistein for 24, 48 or 72 h. In PDGF-induced HSC proliferation, HSC were stimulatel with L0μg@L-1PDGF-BB for 15 min, and then treaeed with genisteinfor the same time. Cell proliferation was measured byMTr assay and based on flow cytometric analysis of cellcycle. The a-smooth muscle actin (α-SMA) expression inHSC was studied with confocal laser microscopy and flowcytometry. c-fos c-jun and cyclin D1 expression in HSCwas also detected by flow cytometry.RESULTS: Genistein inhibited basal and PDGF-inducedproliferation of HSC at the concentration of 10-8 to 10-5mol/L, and treatment with 10-7 mol/L concentration ofgenistein for 48 h inhibited the HSC proliferationsignificantly (the inhibition rate was 70.3 %, P<0.05).Immunofluorescence detected by confocal lasermicroscopy and flow cytometry showed that treatmentwith 10-7 mol/L genistein for 48 h suppressed theexpression of α-SMA significantly in HSC (the specificfluorescence intensity were 60.2±21.5 vs 35.3±11.6and 12.8± 10.4 vs9.54±6.39, respectively, both P<0.05).The intensity of c-fos, c-jun and cydin D1 expression ofHSCs treated with 10-7 mol/L genistein for 48 h wasalso significantly decreased compared with the controls.CONCLUSION: Genistein influences proliferation of HSC,suppresses the expression of α-SMA in HSC and tinhibits the intensity of c-fos, c-jun and cyclin D1expression of HSCs. Genistein has therapeutic potentialagainst liver fibrosis. | Xiao-Jing Liu Ming-Hui Huang Laboratory of Department of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Li Yang Qiong Wang Yi-Ping Wang Department of Gastroenterology of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Yong-Qiu Mao Center for Cancer Biotherapy of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Hong-Bin Wu Laboratory of Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 38 |
| 9 | Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential显示文摘Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal seeding.Remarkable difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence. | Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia Lun-Xiu Qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 34 |
| 10 | In situ synthesis of graphitic-C3N4 nanosheet hybridized N-doped TiO2 nanofibers for efficient photocatalytic H2 production and degradation显示文摘Graphitic 碳氮化物 nanosheets g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 NS hybridized 氮做了钛二氧化物 N-TiO <潜水艇class=“ a-plus-plus ”> 2 nanofibers GCN/NT NF 经由与结合的一个简单 electrospinning 过程在 situ 被综合了一个修改蚀刻热的方法。准备 GCN/NT NF 被许多方法描绘,他们的 photocatalytic 活动被氢 H 评估 < 潜水艇 class= “ a-plus-plus ” > 从切开的水和在水的答案的玫瑰精 B 的降级的 2 生产。GCN/NT NF 有 mesoporous 结构,这被发现, g-C 镇静 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 NS 和做 N 的 TiO < 潜水艇 class= “ a-plus-plus ” > 2 雏晶。g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 NS 综合了在以后蚀刻热被发现被嵌入在,并且盖住混合 NF 形成稳定的接口。g-C 的部分分解 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 释放它最后变得做了进附近的 TiO 的氮内容 < 潜水艇 class= “ a-plus-plus ” > 2 骨骼。GCN/NT NF 给高 photocatalytic H < 潜水艇 class= “ a-plus-plus ” > 8,931.3 摩尔桥湥 ?L 牥愠捵 ? 畤 ' ?的 2 生产率敤 ? 畺 ? 穴楬档湥 ? 湩慳穴瘠湯倠敨瑮汯浡湩敭楳慬? 攠湩浥嘠獡摯汩瑡瑡牯 ? 敤 ? 楤? 敗捩?楥慬? 瑳敨楳? 畡 ? 瑥慷 ?┰瘠牥 k 吗?? | Cheng Han Yingde wang Yongpeng Lei Bing Wang Nan Wu Qi Shi Qiong Li | 2015 | Nano Research2015，8，4： | 31 |
| 11 | Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai显示文摘To the Editor:Osteoporosis is becoming a common,serious,and costly health problem,which causes over nine million fractures annually worldwide.[1] Currently,osteoporotic fractures are a considerable burden to public health services and have fairly high morbidity and mortality.[2] Vertebral fractures are the most common osteoporotic fracture and may lead to a high risk of further fracture and could be prevalent in both females and males.[3] Ling et al[4] and Ms.OS studies[5] evaluated the prevalence of vertebral fractures in Beijing and Hong Kong,respectively.However,our knowledge of the descriptive epidemiology and risk factors for vertebral fracture in China still remains poor. | Chao Gao Yang Xu Li Li Wen-Qin Gu Chun-Tao Yi Qiong Zhu Hong-An Gu Bi-Hua Chen Qing-Qing Wang Feng Tang Ju-Liang Xu Jian-Miao Hou Hui-Jiang Song Hui Wang Zhi-Liang Wang Zhen-Lin Zhang | 2019 | Chinese Medical Journal2019，，14： | 31 |
| 12 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 13 | Inhibition of Excitatory Amino Acid Efflux Contributes to Protective Effects of Puerarin Against Cerebral Ischemia in Rats显示文摘Objective To investigate whether the protective effects of puerarine(Pur)against cerebral ischemia is associated with depressing the extracellular levels of amino acid transmitters in brain of rats.Methods Male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion(MCAO)for 60 min followed by 24 h reperfusion.Pur(50,100 mg/kg,i.p.)was administered at the onset of MCAO.The infarct rate and edema rate were detected on TTC(2,3,5-triphenyltetrazolium chloride)-stained coronal sections.The extracellular levels of amino acid transmitters were monitored in striatum of rats with ischemic/reperfusion injury using in vivo microdialysis technique.Furthermore,the protective effects of Pur against glutamate-induced neurotoxicity were detected.Glutamate-induced apoptotic and necrotic cells in hippocampus were estimated by flow cytometric analysis of Annexin-V and PI labeling cells.Results Pur(100 mg/kg)significantly decreased infarct size by 31.6%(P<0.05),reduced edema volume(P<0.05),and improved neurological functions(P<0.05)following MCAO.In these rats,the ischemia-induced extracellular levels of aspartate(Asp),glutamate(Glu),γ-aminobutyric acid(GABA),and taurine(Tau)were significantly reduced in striatum of vehicle-treated animals by 54.7%,56.7%,75.8%,and 68.1%(P<0.01 and P<0.05).Pur reduced the peak values of Glu and Asp more obviously than those of GABA and Tau,and the rate of Glu/GABA during MCAO markedly decreased in Pur-treated MCAO rats,compared with the vehicle-treated MCAO rats.Meanwhile,apoptosis and necrosis induced by Glu in cultured hippocampal neurons were significantly reduced after Pur treatment.Conclusion Acute treatment with Pur at the onset of occlusion significantly depresses ischemia-induced efflux of amino acids,especially,excitotoxicity in the striatum,a mechanism underlying the neuroprotective effect on cellular survival. | XIAO-HONG XU XIAO-XIANG ZHENG QIONG ZHOU HUI LI | 2007 | Biomedical and Environmental Sciences2007，20，4： | 30 |
| 14 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 15 | Rayleigh wave phase velocity tomography and strong earthquake activity on the southeastern front of the Tibetan Plateau显示文摘To investigate the relationship between velocity structure and earthquake activity on the southeastern front of the Tibetan Plateau, we make use of continuous observations of seismic ambient noise data obtained at 55 broadband stations from the regional Yunnan Seismic Network. These data are used to compute Rayleigh wave Green's Functions by cross-correlating between two stations, extracting phase velocity dispersion curves, and finally inverting to image Rayleigh wave phase velocity with periods between 5 and 34 s by ambient noise tomography. The results show significant lateral variations in crustal and uppermost mantle structures in the studied region. Phase velocity anomalies at short periods(5–12 s) are closely related to regional tectonic features such as sediment thickness and the depth of the crystalline basement. The Sichuan-Yunnan rhombic block, enclosed by the Honghe, Xiaojiang and Jianchuan faults, emerges as a large range of low-velocity anomalies at periods of 16–26 s, that inverts to high-velocity anomalies at periods of 30–34 s. The phase velocity variation in the vicinity of the Sichuan-Yunnan rhombic block suggests that the low-velocity anomaly area in the middle-lower crust may correspond to lower crustal channelized flow of the Tibetan Plateau. The spatial distribution of strong earthquakes since 1970 reveals that the Yunnan region is inhomogeneous and shows prominent characteristics of block motion. However, earthquakes mostly occur in the upper crust, with the exception of the middle-Yunnan block where earthquakes occur at the interface zone between high and low velocity as well as in the low-velocity zones, with magnitudes being generally less than 7. There are few earthquakes of magnitude 5 at the depths of 15–30 km, where gather earthquakes of magnitude 7 or higher ones which mainly occur in the interface zone between high and low velocities with others extending to the high-velocity abnormal zone. | WANG Qiong GAO Yuan | 2014 | Science China Earth Sciences2014，57，10： | 30 |
| 16 | Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L显示文摘Arctigenin (AR ) 和它的 glycoside, arctiin,是 Arctium lappa L (lappa ) 的二主要活跃成分,流行药用的植物和健康补充经常在亚洲使用了。在过去的几十年,从 lappa 的 bioactive 部件由于他们答应治疗学的效果吸引了研究人员的注意。在当前的文章,我们试图提供 AR 和 arctiin 的药理学的概述,集中于他们的反煽动性的效果, pharmacokinetics 性质和临床的功效。比作 acrtiin, AR 在研究的多数作为 lappa 的大多数有势力 bioactive 部件被报导。AR 展览有势力由经由几 cytokines 的调整禁止可诱导的氮的氧化物 synthase (iNOS ) 的反煽动性的活动。由于它的有势力反煽动性的效果, AR 可以对尖锐发炎和各种各样的长期的疾病用作潜在的治疗学的混合物。然而, pharmacokinetic 研究在肝,肠和血浆表明了 AR 的广泛的 glucuronidation 和水解作用,它可能妨碍它的在里面在口头的管理以后的 vivo 和临床的功效。经由其他的管理线路基于考察药理学和 AR,进一步的 pharmacokinetic 和 AR 的 pharmacodynamic 研究的 pharmacokinetic 特征被建议支持它的能力为 lappa 象一个理想的 bioactive 标记一样用作一个治疗学的代理人。 | Qiong GAO Mengbi YANG Zhong ZUO | 2018 | Acta Pharmacologica Sinica2018，39，5： | 30 |
| 17 | Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells显示文摘Emodin (1,3,8-trihydroxy-6-methylanthraquinone) could enhance the sensitivity of tumor cells to arsenic trioxide(As2O3)–induced apoptosis via generation of ROS, but the molecular mechanism has not been elucidated. Here, wecarried out cDNA microarray-based global transcription profiling of HeLa cells in response to As2O3/emodin cotreatment,comparing with As2O3–only treatment. The results showed that the expression of a number of genes was substantiallyaltered at two time points. These genes are involved in different aspects of cell function. In addition to redox regulationand apoptosis, ROS affect genes encoding proteins associated with cell signaling, organelle functions, cell cycle,cytoskeleton, etc. These data suggest that based on the cytotoxicity of As2O3, emodin mobilize every genomic resourcethrough which the As2O3–induced apoptosis is facilitated. | Xiao Jing WANG Jie YANG Hui CANG Yan Qiong ZOU Jing YI | 2005 | Cell Research2005，15，7： | 28 |
| 18 | Heavy metal contamination and source in arid agricultural soil in central Gansu Province,China显示文摘铜( Cu )的集中,铅( Pb ),铬( Cr ),水银( Hg ),和砷(作为)在在 Daba 村庄, Shajiawuan 村庄, Gangou 村庄和 Sifangwu 村庄里收集的干旱农业、灌溉的农业土壤被测量,在中央 Gansu 省定位了,除了 Hg 和 Pb 的 China.Concentrations 比在在选择干旱农业 soils.Pb 集中的灰石灰性土壤的背景价值由结果显示出的72.46% .These 在中国超过干旱农业土壤的阀值低有有 Pb 的确实严肃的污染,为在 Daba 村庄里的灌溉农业土壤的另外的选择金属的一个细微污染问题。种量分析(PCA ) 被用来估计土壤数据,使用有凯撒正规化的 varimax 旋转。结果证明灌溉因素,农业因素和人为的因素都贡献了在选择化学特性之间的关系。Cu 的累积的主要因素, Pb, Cr, Hg 并且这是石版印刷在干旱农业区域的逻辑因素。有 Cu 的起源的惹人注目的不同, Pb, Cr, Hg 并且作为在在 irrigate 农业和干旱农业之间的农业土壤。 | LI Yu GOU Xin WANG Gang ZHANG Qiang SU Qiong XIAO Guoju | 2008 | Journal of Environmental Sciences2008，20，5： | 27 |
| 19 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 20 | Modified vitrification method for cryopreservation of human ovarian tissues显示文摘背景玻璃化是在卵巢的织物 cryopreservation 的一种未来的技术,但是它仍然在一个起始的阶段。这研究被进行为人的卵巢的组织调查一个修改玻璃化协议,它能被用作一种选择保存生育力因为有到的有癌症的年轻女人经历细胞毒素的治疗和消毒。方法卵巢的织物样品从 15 个病人被收集并且随机分配了到一些新鲜,玻璃化,并且常规慢结冰。一个修改无搬运人的玻璃化方法被使用。在新鲜卵巢的纸巾的词法上未经触动的滤泡的比例在温暖 / 融化的纸巾与那相比。滤泡的起始的生长和 estradiol 和孕酮的集中被检测决定生存能力和在新鲜的组(97.6%)的词法上未经触动的初发的滤泡的比例是的 cryopreserved tissues.Results 的内分泌的功能比那显著地高在另外的二个组(玻璃化组80.3%并且慢结冰组织72.6%, P0.001 )。在玻璃化和慢结冰的组, estradiol 和孕酮在 vitro 在 2 星期的文化期间连续地被分泌,主要滤泡的比例显著地两个都与新鲜的组相比被增加。没有统计上重要的差别在 estradiol 和为人的卵巢的纸巾的 cryopreservation 的修改玻璃化方法是的孕酮(P0.05 ).Conclusion 的初发、主要的滤泡,和集中的比例在 cryopreservation 以后在二个组之间存在有效、简单、便宜。 | LI Yu-bin ZHOU Can-quan YANG Guo-fen WANG Qiong DONG Yu | 2007 | Chinese Medical Journal2007，，2： | 26 |
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