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| 1 | Loss of microRNAs in thymus perturbs invariant NKT cell development and function显示文摘microRNAs(miRNAs)are small noncoding RNAs that mediate RNA interference to suppress protein expression at the translational level.Accumulated evidence indicates that miRNAs play critical roles in various biological processes and disease development,including autoimmune diseases.Invariant natural killer T(iNKT)cells are an unusual CD1d-restricted subset of thymus-derived T cells that are potent regulators of diverse immune responses.Our previous studies with the mouse model of bone marrow-specific Dicer deletion suggest the involvement of Dicer-dependent miRNAs in the development and function of iNKT cells.In the present study,to further dissect the functional levels of Dicer-dependent miRNAs in regulating iNKT cell development,we generated a mouse model with the Dicer deletion in the thymus.Our data indicate that lack of miRNAs following the deletion of Dicer in the thymus severely interrupted the development and maturation of iNKT cells in the thymus and significantly decreased the number of iNKT cells in the peripheral immune organs.miRNA-deficient peripheral iNKT cells display profound defects in activation and cytokine production upon a-galactosylceramide(a-GalCer)stimulation.Our results demonstrate a critical role of the miRNA-dependent pathway in the thymus in the regulation of iNKT cell development and function. | Kook-Heon Seo Li Zhou Dongmei Meng Jianrui Xu Zhong Dong Qing-Sheng Mi | 2010 | Cellular & Molecular Immunology2010，7，6： | 9 |
| 2 | Energy Loss Analysis of Novel Self-Priming Pump Based on the Entropy Production Theory显示文摘The conventional method cannot explicitly confirm the location and type of the energy loss, therefore this paper employs the entropy production theory to systematically analyze the category, magnitude and location of hydraulic loss under different blade thickness distribution. Based on the analysis, the turbulent entropy and viscosity entropy produced by the separation of boundary layer at the trialing edge are major factors leading to the hydraulic loss. In addition, the separation of the boundary layer can not only cause the energy loss, but also block the passage of the impeller and reduce the expelling coefficient of the blade. Therefore, the hydraulic performance of the blades with increment thickness distribution is obviously better than the decrement one. Further, the flow rate has different influence on the three types of entropy production. Meanwhile, the pressure pulsation on the working surface was investigated. It was concluded that with flow rates increasing, the amplitude of pressure pulsation firstly decreases and then smoothly improves, and reaches the minimum under design flow rate. Finally, the optimal blade was obtained, and the relevant hydraulic performance test was performed to benchmark the simulation result. This research can provide the theoretical reference for designing the reasonable thickness distribution of the blades. | CHANG Hao SHI Weidong LI Wei LIU Jianrui | 2019 | Journal of Thermal Science2019，28，2： | 6 |
| 3 | Cooperative and Competitive Multi-Agent Systems:From Optimization to Games显示文摘Multi-agent systems can solve scientific issues related to complex systems that are difficult or impossible for a single agent to solve through mutual collaboration and cooperation optimization.In a multi-agent system,agents with a certain degree of autonomy generate complex interactions due to the correlation and coordination,which is manifested as cooperative/competitive behavior.This survey focuses on multi-agent cooperative optimization and cooperative/non-cooperative games.Starting from cooperative optimization,the studies on distributed optimization and federated optimization are summarized.The survey mainly focuses on distributed online optimization and its application in privacy protection,and overviews federated optimization from the perspective of privacy protection me-chanisms.Then,cooperative games and non-cooperative games are introduced to expand the cooperative optimization problems from two aspects of minimizing global costs and minimizing individual costs,respectively.Multi-agent cooperative and non-cooperative behaviors are modeled by games from both static and dynamic aspects,according to whether each player can make decisions based on the information of other players.Finally,future directions for cooperative optimization,cooperative/non-cooperative games,and their applications are discussed. | Jianrui Wang Yitian Hong Jiali Wang Jiapeng Xu Yang Tang Qing-Long Han Jürgen Kurths | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，5： | 5 |
| 4 | Changes and correlation of microorganism and flavor substances during persimmon vinegar fermentation显示文摘To investigate the microbial diversity and the change of the flavor substances during the traditional natural persimmon vinegar fermentation,two group samples from alcohol fermentation stage(A)and acetic acid fermentation stage(B)were analyzed.The results showed that Burkholderia,Lactobacillus,Acetobacter,Komagataeibacter were the main bacteria,and the major fungi were Saccharomyces,Hanseniaspora,Hortaea,and Cladosporium at the genus level.The contents of flavonoids and polyphenols in B increased by 17.91%and 26.59%compared with A,respectively.The superoxide anion scavenging activity significantly increased by 20.15%.The contents of total free amino acids were 5709.99±410.36 mg/L and 5736.16±472.02 mg/L,and the total contents of 9 organic acids were 19.89±1.20 g/L and 33.77±2.49 g/L in samples A and B,respectively.Pearson correlation analysis showed that 11 flavor compounds were related to Lactobacillus and Leuconostoc;8 and 10 compounds were respectively related to Komagataeibacter and Acetobacter;13 and 19 flavor compounds were respectively associated with Saccharomyces and Monascus.Orthogonal Partial Least Square(OPLS)model showed that the contents of Leu,Lys,and lactic acid were mainly associated with fungi,andγ-aminobutyric acid(GABA)content was correlated with Lactobacillus,Acetobacter,Leuconostoc,and Saccharomyces.This study revealed the relationship between microbial diversity and flavor compounds in persimmon vinegar produced by spontaneous fermentation.The results can provide a theoretical support for the safety and health assessment of persimmon vinegar. | Dahong Wang Mengyang Wang Luwei Cao Xiaotong Wang Jianrui Sun Jiangfeng Yuan Shaobin Gu | 2022 | Food Bioscience2022，46，2： | 4 |
| 5 | Influence of Blade Thickness on Transient Flow Characteristics of Centrifugal Slurry Pump with Semi-open Impeller显示文摘As the critical component, the impellers of the slurry pumps usually have blades of a large thickness. The increasing excretion coefficient of the blades affects the flow in the impeller resulting in a relatively higher hydraulic loss, which is rarely reported.In order to investigate the influence of blade thickness on the transient flow characteristics of a centrifugal slurry pump with a semi-open impeller, transient numerical simulations were carried out on six impellers, of which the meridional blade thickness from the leading edge to trailing edge varied from 5?10 mm, 5?15 mm, 5?20 mm, 10?10 mm, 10?15 mm, and 10?20 mm, respectively. Then,two of the six impellers, namely cases 4 and 6, were manufactured and experimentally tested for hydraulic performance to verify the simulation results. Results of these tests agreed reasonably well with those of the numerical simulation. The results demonstrate that when blade thickness increases, pressure fluctuations at the outlet of the impeller become severe. Moreover, the standard deviation of the relative velocity in the middle portion of the suction sides of the blades decreases and that at the outlet of the impeller increases.Thus, the amplitude of the impeller head pulsation for each case increases. Meanwhile, the distribution of the time-averaged relative flow angle becomes less uniform and decreases at the outlet of the impeller. Hence, as the impeller blade thickness increases, the pump head drops rapidly and the maximum efficiency point is offset to a lower flow rate condition. As the thickness of blade trailing edge increases by 10 mm, the head of the pump drops by approximately 5 m, which is approximately 10 % of the original pump head.Futhermore, it is for the first time that the time-averaged relative flow angle is being considered for the analysis of transient flow in centrifugal pump. The presented work could be a useful guideline in engineering practice when designing a centrifugal slurry pump with thick impeller blades. | TAO Yi YUAN Shouqi LIU Jianrui ZHANG Fan TAO Jianping | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 4 |
| 6 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication显示文摘Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein(GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A(VAP-A) in competition with the HCV NS5 A, causing an interruption of the complex formation between VAP-A and HCV NS5 A. As the formation of VAP-A/NS5 A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5 A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents(DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication. | Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 7 | An optimal dose of tea polyphenols protects against global cerebral ischemia/reperfusion injury显示文摘Previous studies addressing the protection of tea polyphenols against cerebral ischemia/ reperfusion injury often use focal cerebral ischemia models, and the optimal dose is not unified. In this experiment, a cerebral ischemia/reperfusion injury rat model was established using a modified four-vessel occlusion method. Rats were treated with different doses of tea polyphenols (25, 50, 100, 150, 200 mg/kg) via intraperitoneal injection. Results showed that after 2, 6, 12, 24, 48 and 72 hours of reperfusion, peroxide dismutase activity and total antioxidant capacity in brain tissue gradually increased, while malondialdehyde content gradually decreased after tea polyphenol intervention. Tea polyphenols at 200 mg/kg resulted in the most apparent changes. Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotic cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury. The open field test and elevated plus maze experiments showed that tea polyphenols at 200 mg/kg strengthened exploratory behavior and reduced anxiety of cerebral ischemia/reperfusion injured rats. Experimental findings indicate that tea polyphenols protected rats against cerebral ischemia/ reperfusion injury and 200 mg/kg is regarded as the optimal dose. | Jianrui Lv Rongliang Xue Jing Zhao Xin Wei Hui Gao Rongguo Fu Gang Wu Wei Li Xiaoming Lei Junbin Tian | 2013 | Neural Regeneration Research2013，8，9： | 3 |
| 8 | Single-phase-to-ground fault protection based on zero-sequence current ratio coefficient for low-resistance grounding distribution network显示文摘Definite-time zero-sequence over-current protection is presently used in systems whose neutral point is grounded by a low resistance(low-resistance grounding systems).These systems frequently malfunction owing to their high settings of the action value when a high-impedance grounding fault occurs.In this study,the relationship between the zero-sequence currents of each feeder and the neutral branch was analyzed.Then,a grounding protection method was proposed on the basis of the zero-sequence current ratio coefficient.It is defined as the ratio of the zero-sequence current of the feeder to that of the neutral branch.Nonetheless,both zero-sequence voltage and zero-sequence current are affected by the transition resistance,The influence of transition resistance can be eliminated by calculating this coefficient.Therefore,a method based on the zero-sequence current ratio coefficient was proposed considering the significant difference between the faulty feeder and healthy feeder.Furthermore,unbalanced current can be prevented by setting the starting current.PSCAD simulation results reveal that the proposed method shows high reliability and sensitivity when a high-resistance grounding fault occurs. | Jianrui Li Yongli Li Yonghuan Wang Jinzhao Song | 2021 | Global Energy Interconnection2021，4，6： | 3 |
| 9 | The potent different risk factors for cerebral infarction in young patients with and without type 2 diabetes: Subanalysis of the Young Cerebral Infarction Study (YCIS)显示文摘 | Bin Zhang Cong Gao Qinghua Hou Jianrui Yin Longchang Xie Shuxiang Pu Yonghong Yi Qingchun Gao | 2011 | Atherosclerosis2011，，1： | 3 |
| 10 | Experimental Optimization of Jet Self-Priming Centrifugal Pump Based on Orthogonal Design and Grey-Correlational Method显示文摘The novel jet self-priming centrifugal pump,as important modern irrigation equipment,is widely used in large-scale irrigation,mine drainage and so on.In order to improve the profile streamline of blade,the inlet shape of impeller was designed as distorted and the outlet shape as cylindrical,which can not only improve the pump efficiency,but also shorten the self-priming time.Further,the novel jet self-priming system was proposed,by employing the jet nozzle and check valve to improve the velocity of self-priming.Meanwhile,nine different structure jet nozzles were designed based on the orthogonal design method,and the relevant self-priming experiments were performed on I level accuracy test bench in Jiangsu University.According to the greycorrelational analysis,the influence of the nozzle geometry parameters on the self-priming performance was obtained.The relationship between self-priming time and self-priming height was discussed.The test results showed that the hydraulic design of jet self-priming centrifugal pump was reasonable;all indicators met the Chinese national standard;the head reached 21.04 m and efficiency was 72.8%under the design flow condition.What is more,the self-priming performance was obviously improved by adjusting the geometrical parameters of nozzle.When the height of the self-priming process was 5.3 m,the self-priming time reached 62 s,which was much shorter than the national standard.Therefore,this research could provide reference for designing the structure of jet self-priming centrifugal pump. | CHANG Hao SHI Weidong LI Wei WANG Chuan ZHOU Ling LIU Jianrui YANG Yongfei RAMESH KAgarwal | 2020 | Journal of Thermal Science2020，29，1： | 3 |
| 11 | Porous carbon coupled with an interlaced MoP–MoS2 heterojunction hybrid for efficient hydrogen evolution reaction显示文摘The design and development of electrocatalysts composed of non-noble-metal catalysts with both large surface area and high electrical conductivities are crucial for the hydrogen evolution reaction(HER).Here,a xylose-based porous carbon is coupled with a MoS2-Mo P heterojunction(MoS2-Mo P/FPC)hybrid and used as a promising catalyst for HER.The hybrid is prepared by immobilizing petal-like MoS2 nanosheets on porous carbon(MoS2/FPC),followed by controlling the phosphidation in Ar/H2 to form MoS2-Mo P/FPC.Red phosphorus provides the P species that can induce the construction of the heterojunction under the reducing atmosphere,along with the generation of a Mo P phase and the splitting of the MoS2 phase.The as-prepared MoS2-Mo P/FPC catalyst offers a low overpotential of 144 mV at a current density of 10 m A cm^-2 and a small Tafel slope of 41 m V dec^-1 for the HER in acidic media,as well as remarkable stability.Apart from the active nature of the hybrid,its outstanding activity is attributed to the MoS2-Mo P heterojunction,and the good charge/mass-transfer ability of porous carbon.This strategy provides a new method to develop and design low-cost and high-performance catalysts for the HER. | Qiusheng Zhou Jianrui Feng Xinwen Peng Linxin Zhong Runcang Sun | 2020 | Journal of Energy Chemistry2020，29，6： | 2 |
| 12 | NiCo_(2)O_(4) hollow microsphere-mediated ultrafast peroxymonosulfate activation for dye degradation显示文摘Morphology and dispersity are key factors for activating peroxymonosulfate(PMS).In this study,we designed a recyclable open-type NiCo_(2)O_(4) hollow microsphere via a simple hydrothermal method with the assistance of an NH_(3) vesicle.The physical structure and chemical properties were characterized using techniques such as scanning electron microscope(SEM),transmission electron microscope(TEM),X-ray diffraction(XRD),N2 adsorption and X-ray photoelectron spectroscopy(XPS).The test results confirm that the inner and outer surfaces of open-type NiCo_(2)O_(4) hollow-sphere can be efficiently utilized because of the hole on the surface of the catalyst,which can minimize the diffusion resistance of the reactants and products.Under optimized conditions,the total orga nic carbon(TOC) removal efficiency of rhodamine B(RhB) can reach up to 80% in 40 min,which is almost 50% shorter than the reported values.The reactive radicals were identified and the proposed reaction mechanism was well described.Moreover,the disturbances of HCO_(3)^(-),NO_(3)^(-),Cl^(-)and H_(2) PO_(4)^(-)were further investigated.As a result,HCO_(3)-and NO_(3)-suppressed the reaction while Cl-and H_(2) PO4-had a double effect on reaction. | Pengjia Ding Jianrui Niu Fengqin Chang Zhuang He Thomas Wagberg Zaixing Li Guangzhi Hu | 2021 | Chinese Chemical Letters2021，32，8： | 2 |
| 13 | Sex differences in risk factors, etiology, and short-term outcome of cerebral infarction in young patients显示文摘 | Bin Zhang ShuXiang Pu WeiZhi Zhang Ning Yang Gang Shen JianRui Yin YongHong Yi QingChun Gao Cong Gao | 2011 | Atherosclerosis2011，，2： | 2 |
| 14 | 显示文摘 | Liu Jianrui Guo Yina Huang Weidong | 2006 | Surface and Coatings Technology2006，201，： | 1 |
| 15 | Coordination behavior between zinc salts and L-α-methionine显示文摘The solubility properties of ZnCl\-2/ZnAc\-2/ZnSO\-4MetH\-2O systems at 25℃ in the whole cocentration range have been investigated by phase equilibrium method. The results indicate that ZnAc\-2 and ZnSO\-4 systems are both simple systems, which do not exist any compound; there are 2 complexes formed in ZnCl\-2 system: Zn(Met)Cl\-2 and Zn(Met)\-2Cl\-2·2H\-2O. Under the direction of phase equilibrium result, 2 solid complexes have been prepared in water and characterized by chemical analysis, IR, Xray diffraction. Their combustion energies have also been determined by means of a RBCtype1 rotatingbomb calorimeter, and their standard enthalpies of formation, Δ f, coor(s)H O-, have been calculated which are (-828.32±3.00) kJ·mol -1 and (-1 117.08±6.15) kJ·mol -1, respectively. | Shengli Gao Jianrui Liu Mian Ji Xuwu Yang Fengxing Zhang Zhongjin Li | 1998 | Chinese Science Bulletin1998，43，18： | 1 |
| 16 | Study on the Corrosion Re-sistance of PHytic Acid Conversion Coating for Magnesium Alloys显示文摘 | Liu Jianrui Guo Yina Huang Weidong | 2006 | Surface&Coating Technology2006，201，： | 1 |
| 17 | Study on the con'o- sion resistance of phytic acid conversion coating 显示文摘 | Liu Jianrui Guo Yina Huang Weidong | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 18 | The protectivesurface film formed on molten ZK60 magnesium alloy in1,1,1,2-tetrafluoroethane/air atmospheres 显示文摘 | Chen Hukui Liu Jianrui Huang Weidong | 2010 | CorrosionScience2010，52，： | 1 |
| 19 | Advances and challenges in two-dimensional materials for oxygen evolution显示文摘Oxygen evolution reaction(OER)plays an important role in many energy conversions and storage technologies,such as water splitting,rechargeable metal air batteries,renewable fuel cells,and electrocatalytic carbon dioxide reduction and nitrogen reduction,but its slow kinetics and high overpotential seriously affect the energy efficiency.Fabrication of high-performance and well-stocked OER catalysts is the key to the large-scale implementation of these energy-related technologies.Two-dimensional(2D)materials get a lot of attention as OER catalysts due to their large specific surface area,abundant active sites,and adjustable structures and compositions.Here,an overview is presented for the latest achievements in design and synthesis of 2D materials(including layered double hydroxides,metal-organic frameworks and their derivatives,covalent-organic frameworks,graphene,and black phosphorus)for the OER,emphasizing novel strategies(including metal/nonmetal doping,defect engineering,interface engineering,lattice strain,and fabrication of heterojunction)for achieving high electrocatalytic activity.Peculiarly,the structure–function relationship is analyzed in detail to gain deeper insight into the reaction mechanism,which is crucial to rational design of more high-performance 2D materials for the OER.Finally,the remaining challenges to improve the OER performance of 2D electrocatalysts are put forward to indicate possible future development of 2D materials. | Tianmi Tang Saisai Li Jianrui Sun Zhenlu Wang Jingqi Guan | 2022 | Nano Research2022，15，10： | 1 |
| 20 | Several factors affecting the detection of pile foundation quality analysis 显示文摘 | Zhou Tao pay Jianrui | 2009 | China Construction information2009，14，： | 1 |
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