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18篇 您的检索式:作者名="Jiang Dewei"
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1Recent progress of surface coating on cathode materials for high-performance lithium-ion batteries显示文摘Lithium-ion batteries (LIB) have received substantial attention in the last 10 years,as they offer great promise as power sources that can lead to the electric vehicle (EV) revolution in the next 5 years.Since the cathode serves as a key component in LIB,its properties significantly affect the performance of the whole system.Recently,the cathode surface modification based on coating technique has been widely employed to enhance the electrochemical performances by improving the material conductivity,stabilising the physical structure of materials,as well as preventing the reactions between the electrode and electrolyte.In this work,we reviewed the present of a number of promising cathode materials for Li-ion batteries.After that,we summarized the very recent research progress focusing on the surface coating strategies,mainly including the coating materials,the coating technologies,as well as the corresponding working mechanisms for cathodes.At last,the challenges faced and future guidelines for optimizing cathode materials are discussed.In this study,we propose that the structure of cathode is a crucial factor during the selection of coating materials and technologies.Peiyuan Guan Lu Zhou Zhenlu Yu Yuandong Sun Yunjian Liu Feixiang Wu Yifeng Jiang Dewei Chu 2020Journal of Energy Chemistry2020,29,4:28
2Development of a Drilling and Coring Test-bed for Lunar Subsurface Exploration and Preliminary Experiments显示文摘Drill sampling has been widely employed as an effective way to acquire deep samples in extraterrestrial exploration. A novel sampling method, namely, flexible-tube coring, was adopted for the Chang'e mission to acquire drilling cores without damaging stratification information. Since the extraterrestrial environment is uncertain and different from the terrestrial environment, automated drill sampling missions are at risk of failure. The principles of drilling and coring for the lunar subsurface should be fully tested and verified on earth before launch. This paper proposes a test-bed for conducting the aforementioned experiments on earth. The test-bed comprises a rotary-percussive drilling mechanism, penetrating mechanism, drilling medium container, and signal acquisition and control system. For granular soil, coring experiments indicate that the sampling method has a high coring rate greater than 80%. For hard rock, drilling experiments indicate that the percussive frequency greatly affects the drilling efficiency. A multi-layered simulant composed of granular soil and hard rock is built to test the adaptability of drilling and coring. To tackle complex drilling media, an intelligent drilling strategy based on online recognition is proposed to improve the adaptability of the sampling drill. The primary features of this research are the proposal of a scheme for drilling and coring a test-bed for validation on earth and the execution of drilling experiments in complex media.SHI Xiaomeng DENG Zongquan QUAN Qiquan TANG Dewei HOU Xuyan JIANG Shengyuan 2014Chinese Journal of Mechanical Engineering2014,27,4:10
3Drilling Power Consumption and Soil Conveying Volume Performances of Lunar Sampling Auger显示文摘The sampling auger used in lunar sampling and return mission is to transmit power and convey soil, and its performance is the key factor of the whole mission. However, there is currently a lack of the optimization research on soil conveying volume and power consumption models in auger structure design. To provide the drilled object, the simulation lunar soil, whose physical and mechanical property is the same as the real soil, is made by reducing soil void ratio. The models are formulated to analyze the influence of auger structure parameters on power consumption and soil conveying volume. To obtain the optimized structure parameters of auger, the multi-objective optimization functions of the maximum soil conveying volume and minimum power consumption are developed. To verify the correctness of the models, the performances of different augers drilling simulation soil are tested. The test results demonstrate that the power consumption of optimized auger is the lowest both in theory and test, and the experimental results of soil conveying volume are in agreement with theoretical analysis. Consequently, a new method for designing a lunar sampling auger is proposed which includes the models of soil conveying volume and transportation power consumption, the optimization of structure parameters and the comparison tests. This method provides a reference for sampling auger designing of the Chinese Lunar Sample Mission.TIAN Ye TANG Dewei DENG Zongquan JIANG Shengyuan QUAN Qiquan 2015Chinese Journal of Mechanical Engineering2015,28,3:9
4EphA2:A promising therapeutic target in breast cancer显示文摘Ephrin type-A receptor 2(EphA2),a receptor tyrosine kinase,is overexpressed in human breast cancers often linked to poor patient prognosis.Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression,such as proliferation,survival,migration,invasion,drug resistance,metastasis,and angiogenesis.As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity,EphA2 has become a promising therapeutic target for breast cancer treatment.Here,we summarize the expression,functions,mechanisms of action,and regulation of EphA2 in breast cancer.We also list the potential therapeutic strategies targeting EphA2.Furthermore,we discuss the future directions of studying EphA2 in breast cancer.Ping Zhao Dewei Jiang Yunchao Huang Ceshi Chen 2021Journal of Genetics and Genomics2021,48,4:5
5Reaction mechanism and microstructure development of ZrSi_(2) melt-infiltrated C_(f)/SiC-ZrC-ZrB_(2) composites:The influence of preform pore structures显示文摘Reactive melt infiltration(RMI)is an effective method for fabrication of highly dense carbon fiber reinforced ultra-high temperature ceramic matrix composites(Cf/UHTCs).In this work,C_(f)/SiC-ZrC-ZrB_(2)composites were fabricated by infiltrating ZrSi_(2)melt into porous C_(f)/B_(4)C-C preforms,where the physical and chemical reactions involved during the RMI process were identified and analyzed.Inhomogeneous infiltration between the inter-and intra-bundle pores was revealed,and was found to be strongly related to the pore structures of the C_(f)/B_(4)C-C preform.It is indicated that the inhomogeneous infiltration can be mitigated remarkably with increasing porosity and pore size of the preform.The effect of pore size on the RMI process was also investigated by a quantitative model,which agrees very well with the experiment results.It further indicates that the inhomogeneous infiltration can also be relieved at elevated RMI temperature.However,excessive infiltration at elevated temperature or more porous preform may cause serious erosion on interphase and fibers,leading to mechanical properties deterioration of the final composites.Xiaowu Chen Dewei Ni Yanmei Kan Youlin Jiang Haijun Zhou Zhen Wang Shaoming Dong 2018Journal of Materiomics2018,4,3:5
6The effects of orientation control via tension-compression on microstructural evolution and mechanical behavior of AZ31 Mg alloy sheet显示文摘The grain orientation control via twinning activity on deformation features is of great significance to offer a key insight into understanding the deformation mechanism of Mg alloy sheets.The{10–12}twinning were performed by pre-strain paths,i.e.,tension(6%)and compression(5%)perpendicular to the c-axis along extrusion direction(ED),to investigate the microstructural evolution and mechanical properties of AZ31 Mg alloy sheets.The distinction in the texture evolution and strain hardening behavior was illustrated in connection with the pre-strain paths for the activities of twinning and slip.The result shows that the activation of the deformation mode was closely bound up with the grain orientation and the additional applied load direction.The{10–12}twin-texture components with c-axis//ED were generated by precompression,which can provide an appropriate alternative to accommodate the thin sheet thickness strain and enhance the room temperature formability of Mg alloy sheet.Qingshan Yang Bin Jiang Bo Song Zujian Yu Dewei He Yanfu Chai Jianyue Zhang Fusheng Pan 2022Journal of Magnesium and Alloys2022,10,2:4
7Two-Stage Transformerless Dual-Buck PV Grid-Connected Inverters with High Efficiency显示文摘A semi-two-stage common-ground-type transformerless dual-buck-based grid-connected inverter is proposed in this paper.The common-ground-type topology can eliminate common mode(CM)leakage current by connecting the negative terminal of the photovoltaic(PV)directly to the neutral point of the grid,which bypasses the PV array’s stray capacitance.The dual-buck-based topology guarantees increased robustness since the dc-link cannot be short-circuited by a shoot-through event.The semi-two-stage topology features multi-level characteristic,which has a lower forward-voltage drop and smaller dv/dt.Compared with the conventional two-stage inverter,the proposed topology achieves higher efficiency and higher reliability.Experimental results of a 1.5kW prototype show that the proposed inverter is able to achieve high efficiency and low leakage currents.Li Zhang Fengkai Jiang Dewei(David)Xu Kai Sun Yongqiang Hao Tao Zhang 2018Chinese Journal of Electrical Engineering2018,4,2:4
8Multi-state autonomous drilling for lunar exploration显示文摘Due to the lack of information of subsurface lunar regolith stratification which varies along depth, the drilling device may encounter lunar soil and lunar rock randomly in the drilling process. To meet the load safety requirements of unmanned sampling mission under limited orbital resources, the control strategy of autonomous drilling should adapt to the indeterminable lunar environments. Based on the analysis of two types of typical drilling media(i.e., lunar soil and lunar rock), this paper proposes a multi-state control strategy for autonomous lunar drilling. To represent the working circumstances in the lunar subsurface and reduce the complexity of the control algorithm, lunar drilling process was categorized into three drilling states: the interface detection, initiation of drilling parameters for recognition and drilling medium recognition. Support vector machine(SVM) and continuous wavelet transform were employed for the online recognition of drilling media and interface, respectively. Finite state machine was utilized to control the transition among different drilling states. To verify the effectiveness of the multi-state control strategy, drilling experiments were implemented with multi-layered drilling media constructed by lunar soil simulant and lunar rock simulant. The results reveal that the multi-state control method is capable of detecting drilling state variation and adjusting drilling parameters timely under vibration interferences.The multi-state control method provides a feasible reference for the control of extraterrestrial autonomous drilling.Chen Chongbin Quan Qiquan Shi Xiaomeng Deng Zongquan Tang Dewei Jiang Shengyuan 2016Chinese Journal of Aeronautics2016,29,5:3
9Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORCl and scavenging ROS显示文摘Weight loss and cachexia are common problems in colorectal cancer patients;thus,parenteral and enteral nutrition support play important roles in cancer care.However,the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied.In this study,we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival(P<0.001)than those who did not.Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice,predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis,resulting in mTORCl activation.mTORCl inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation.In addition,cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione.We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin.These findings indicate that cyst(e)ine;as part of supplemental nutrition,plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival.Jiao Wu Sai-Ching Jim Yeung Sicheng Liu Aiham Qdaisat Dewei Jiang Wenli Liu Zhuo Cheng Wenjing Liu Haixia Wang Lu Li Zhongmei Zhou Rong Liu Chuanyu Yang Ceshi Chen Runxiang Yang 2021Signal Transduction and Targeted Therapy2021,6,6:2
10Fabrication and microstructure evolution of C_(sf)/ZrB_(2)-SiC composites via direct ink writing and reactive melt infiltration显示文摘Fiber damage and uniform interphase preparation are the main challenges in conventional short fiber reinforced ceramic matrix composites.In this work,we develop a novel processing route in fabrication of short carbon fiber reinforced ZrB_(2)-SiC composites(C_(sf)/ZrB_(2)-SiC)overcoming the above two issues.At first,C_(sf) preforms with oriented designation and uniform PyC/SiC interphase are fabricated via direct ink writing(DIW)of short carbon fiber paste followed by chemical vapor infiltration.After that,ZrB_(2) and SiC are introduced into the preforms by slurry impregnation and reactive melt infiltration,respectively.Microstructure evolution and optimization of the composites during fabrication are investigated in detail.The as-fabricated C_(sf)/ZrB_(2)-SiC composites have a bulk density of 2.47 g/cm^(3),with uniform weak interphase and without serious fiber damage.Consequently,non-brittle fracture occurs in the C_(sf)/ZrB_(2)-SiC composites with widespread toughening mechanisms such as crack deflection and bridging,interphase debonding,and fiber pull-out.This work provides a new opportunity to the material design and selection of short fiber reinforced composites.Jun LU Dewei NI Chunjing LIAO Haijun ZHOU Youlin JIANG Bowen CHEN Xuegang ZOU Feiyan CAI Yusheng DING Shaoming DONG 2021Journal of Advanced Ceramics2021,10,6:1
11Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation显示文摘Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP.Benfu Zhong Dewei Jiang Yang Hong Lifang Li Li Qiu Ronghui Yang Xiaohan Jin Yawen Song Ceshi Chen Binghui Li 2021Signal Transduction and Targeted Therapy2021,6,3:1
12An effective oxygen electrode based on Ir0.6Sn0.4O2 for PEM water electrolyzers显示文摘An effective oxygen evolution electrode with Ir0.6Sn0.4O2 was designed for proton exchange membrane(PEM)water electrolyzers.The anode catalyst layer exhibits a jagged structure with smaller particles and pores,which provide more active sites and mass transportation channels.The prepared IrSn electrode showed a cell voltage of 1.96 V at 2.0 A cm^-2 with Ir loading as low as 0.294 mg cm^-2.Furthermore,Ir Sn electrode with different anode catalyst loadings was investigated.The IrS n electrode indicates higher mass current and more stable cell voltage than the commercial Ir Black electrode at low loading.Guang Jiang Hongmei Yu Jinkai Hao Jun Chi Zhixuan Fan Dewei Yao Bowen Qin Zhigang Shao 2019Journal of Energy Chemistry2019,28,12:1
13Photorefractive properties of paraelectric potassium lithium tantalate niobate crystal doped with iron显示文摘Hao Tian Zhongxiang Zhou Dewei Gong Haifeng Wang Yongyuan Jiang Chunfeng Hou 2007Optics Communications2007,,6:1
14Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention.Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen 2022Signal Transduction and Targeted Therapy2022,7,9:1
15Characterizations and functions of regulator of G protein signaling (RGS) in fungi 显示文摘Wang Yunchuan Geng Zongyi Jiang Dewei 2013Applied Microbiology and Biotechnology2013,97,18:1
16Interfacial engineering in lead-free tin-based perovskite solar cells显示文摘Lead(Pb)-free Tin(Sn)-based perovskite solar cells(PSCs)have been favored by the community due to their low toxicity,preferable bandgaps,and great potential to achieve high power conversion efficiencies(PCEs).Interfaces engineering plays important roles in developing highly efficient Sn-based PSCs via passivation of trap defects,alignment of energy levels,and incorporation of low-dimensional Sn-based perovskites.In this review,we summarize the development of Pb-free Sn-based perovskites and their applications in devices,especially the strategies of improving the interfaces.We also provide perspectives for future research.Our aim is to help the development of new and advanced approaches to achieving high-performance environment-friendly Pb-free Sn-based PSCs.Zhenxi Wan Huagui Lai Shengqiang Ren Rui He Yiting Jiang Jincheng Luo Qiyu Chen Xia Hao Ye Wang Jingquan Zhang Lili Wu Dewei Zhao 2021Journal of Energy Chemistry2021,30,6:0
17Characterization of tree shrew telomeres and telomerase显示文摘The use of tree shrews as experimental animals for biomedical research is a new practice.Several recent studies suggest that tree shrews are suitable for studying cancers,including breast cancer,glioblastoma,lung cancer,and hepatocellular carcinoma.However,the telomeres and the telomerase of tree shrews have not been studied to date.Here,we characterize telomeres and telomerase in tree shrews.The telomere length of tree shrews is approximately 23 kb,which is longer than that of primates and shorter than that of mice,and it is extended in breast tumor tissues according to Southern blot and flow-fluorescence in situ hybridization(FISH)analyses.Tree shrew spleen,bone marrow,testis,ovary,and uterus show high telomerase activities,which are increased in breast tumor tissues by telomeric repeat amplification protocol assays.The telomere length becomes shorter,and telomerase activity decreases with age.The tree shrew TERT and TERC are more highly similar to primates than to rodents.These findings lay a solid foundation for using tree shrews to study aging and cancers.Jian Sun Wenjing Liu Yongbo Guo Hailin Zhang Dewei Jiang Ying Luo Rong Liu Ceshi Chen 2021Journal of Genetics and Genomics2021,48,7:0
18DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis显示文摘Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly induces Krüppel-like factor 5(KLF5)and can cause docetaxel and cisplatin resistance in TNBC.A super-enhancer can maintain the transcription of KLF5.Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du Chengang Zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi Chen 2024Genes & Diseases2024,11,1:0
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