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您的检索式：作者名="Jiangyu Cai"
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| 1 | Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction显示文摘It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament reconstruction.Herein,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in vivo.Scanning electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP scaffold.Moreover,the hydrophilicity of PET scaffolds was significantly improved after CaP deposition.In vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be involved.In addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET scaffold.More importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET group.Therefore,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo. | Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He Jinzhong Zhao | 2021 | Bioactive Materials2021，6，3： | 4 |
| 2 | Vehicle Detection and Tracking in Car Video Based on Motion Model显示文摘 | Jazayeri A Cai Hongyuan Zheng Jiangyu | | 0，，02： | 1 |
| 3 | A regeneration process-matching scaffold with appropriate dynamic mechanical properties and spatial adaptability for ligament reconstruction显示文摘Ligament regeneration is a complicated process that requires dynamic mechanical properties and allowable space to regulate collagen remodeling.Poor strength and limited space of currently available grafts hinder tissue regeneration,yielding a disappointing success rate in ligament reconstruction.Matching the scaffold retreat rate with the mechanical and spatial properties of the regeneration process remains challenging.Herein,a scaffold matching the regeneration process was designed via regulating the trajectories of fibers with different degradation rates to provide dynamic mechanical properties and spatial adaptability for collagen infiltration.This core-shell structured scaffold exhibited biomimetic fiber orientation,having tri-phasic mechanical behavior and excellent strength.Besides,by the sequential material degradation,the available space of the scaffold increased from day 6 and remained stable on day 24,consistent with the proliferation and deposition phase of the native ligament regeneration process.Furthermore,mature collagen infiltration and increased bone integration in vivo confirmed the promotion of tissue regeneration by the adaptive space,maintaining an excellent failure load of 67.65%of the native ligament at 16 weeks.This study proved the synergistic effects of dynamic strength and adaptive space.The scaffold matching the regeneration process is expected to open new approaches in ligament reconstruction. | Xiaojing Xie Junjie Xu Jing Lin Jia Jiang Yunfan Huang Jun Lu Yuhao Kang Yage Hu Jiangyu Cai Fujun Wang Tonghe Zhu Jinzhong Zhao Lu Wang | 2022 | Bioactive Materials2022，7，7： | 0 |
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