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| 1 | Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats显示文摘AIM: To investigate the protective effect of ketamine on the endotoxin-induced proinflammatory cytokines and NFkappa B activation in the intestine. ETHODS: Adult male Wistar rats were randomly divided into 6 groups: (a) normal saline control, (b) challenged with endotoxin (5 mg/kg) and treated by saline, (c) challenged with endotoxin (5 mg/kg) and treated by ketamine (0.5 mg/kg), (d) challenged with endotoxin (5 mg/kg) and treated by ketamine (5 mg/kg ), (e) challenged with endotoxin (5 mg/kg) and treated by ketamine (50 mg/kg), and (f) saline injected and treated by ketamine (50 mg/kg). After 1, 4 or 6 h, TNF-α and IL-6 mRNA were investigated in the tissues of the intestine (jejunum) by RT-PCR. TNF-α and IL-6 were measured by ELISA. We used electrophoretic mobility shift assay (EMSA) to investigate NF-kappa B activity in the intestine. RESULTS: NF-kappa B activity, the expression of TNF-α and IL-6 were enhanced in the intestine by endotoxin. Ketamine at a dose of 0.5 mg/kg could suppress endotoxininduced TNF-α mRNA and protein elevation and inhibit NFkappa B activation in the intestine. However the least dosage of ketamine to inhibit IL-6 was 5 mg/kg in our experiment. CONCLUSION: Ketamine can suppress endotoxin-induced production of proinflammatory cytokines such as TNF-α and IL-6 production in the intestine. This suppressive effect may act through inhibiting NF-kappa B. | JieSun Xiao-DongWang HongLiu Jian-GuoXu | 2004 | World Journal of Gastroenterology2004，10，7： | 28 |
| 2 | Effect of glutarnate on inflammatory responses of intestine and brain after focal cerebral ischemia显示文摘AIM: To study the modulation of glutamate on post-ischemic intestinal and cerebral inflammatory responses in a ischemic and excitotoxic rat model.METHODS: Adult male rats were subjected to bilateral carotid artery occlusion for 15 min and injection of monosodium glutamate intraperitoneally, to decapitate them at selected time points. Tumor necrosis factor alpha (TNF-α) level and nuclear factor kappa B (NF-κB) activity were determined by enzyme-linked immunosorbant assay (ELISA) and electrophoretic mobility shift assay (EMSA), respectively.Hemodynamic parameters were monitored continuously during the whole process of cerebral ischemia and reperfusion.RESULTS: Monosodium glutamate (MSG) treated rats displayed statistically significant high levels of TNF-α in cerebral and intestinal tissuess within the first 6 h of ischemia. The rats with cerebral ischemia showed a minor decrease of TNF-α production in cerebral and intestinal tissuess. The rats with cerebral ischemia and treated with MSG displayed statistically significant low levels of TNF-α in cerebral and intestinal tissues. These results correlated significantly with NF-κB production calculated at the same intervals. During experiment, the mean blood pressure and heart rates in all groups were stable.CONCLUSION: Glutamate is involved in the mechanism of intestinal and cerebral inflammation responses. The effects of glutamate on cerebral and intestinal inflammatory responses after ischemia are up-regulated at the transcriptional level,through the NF-κB signal transduction pathway. | LeiXu JieSun RanLu QingJi Jian-GuoXu | 2005 | World Journal of Gastroenterology2005，11，5： | 15 |
| 3 | HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma显示文摘AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province.METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics.RESULTS: Allele frequency (AF) of HLA-DRB1·0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs0.1397, P=0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1·0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles.CONCLUSION: HLA-DRB1·0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1·0901may be susceptible to esophageal carcinoma. | JunLin Chang-ShengDeng JieSun Xian-GongZheng XingHuang YanZhou PingXiong Ya-PingWang | 2003 | World Journal of Gastroenterology2003，9，3： | 8 |
| 4 | A New Halogenated Biindole and A New Apo-carotenone from Green Alga Chaetomorpha basiretorsa Setchell显示文摘A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NMR technique, their structures have been elucidated as 4,4′-dichloro-5,5′-dibromo-7,7′-dimethoxy-2,2′-bi-1H-indole and 1′S*,4′R*-8-(4′-hydroxy-2′,6′,6′- trimethylcyclohex-2-enyl)-6-methyloct-3E,5E,7E-trien-2-one, respectively. | DaYongSHI LiJunHAN JieSUN ShuaiLI SuJuanWANG YongChunYANG XiaoFAN JianGongSHI | 2005 | Chinese Chemical Letters2005，16，6： | 6 |
| 5 | Influential factors of prognosis in lamivudine treatment for patients with acute‐on‐chronic hepatitis B liver failure显示文摘 | Li‐JieSun Jian‐WuYu Yong‐HuaZhao PengKang Shu‐ChenLi | 2010 | Journal of Gastroenterology and Hepatology2010，，3： | 1 |
| 6 | Segmentation of carotid plaque using multicontrast 3D gradient echo MRI显示文摘 | WenboLiu NiranjanBalu JieSun XihaiZhao HuijunChen ChunYuan HuilinZhao JianrongXu GuangzhiWang William S.Kerwin | 2012 | J Magn Reson Imaging2012，，4： | 1 |
| 7 | Stabilization of cellular properties and differentiation mutilpotential of human mesenchymal stem cells transduced with hTERT gene in a long‐term culture显示文摘 | GuopingHuang QiangZheng JieSun ChunjuanGuo JinfengYang RuiChen YulingXu GuozhongWang DanShen ZhijunPan JieJin JinfuWang | 2008 | J Cell Biochem2008，，4： | 1 |
| 8 | Templated Growth of Covalently Bonded Three‐Dimensional Carbon Nanotube Networks Originated from Graphene显示文摘 | YifengFu Bj?rnCarlberg NiklasLindahl NiclasLindvall JohanBielecki AleksandarMatic YuxinSong ZhiliHu ZongheLai LileiYe JieSun YahuiZhang YanZhang JohanLiu | 2012 | Adv Mater2012，，12： | 1 |
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