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| 1 | Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability显示文摘Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.The particle technology involves several approaches from the conventional size reduction processes to the newer,novel particle technologies that modify the solubility properties of the drugs and produce solid,powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms.This review highlights the solid particle technologies available for improving solubility,dissolution and bioavailability of drugs with poor aqueous solubility. | Prakash Khadka Jieun Ro Hyeongmin Kim Iksoo Kim Jeong Tae Kim Hyunil Kim Jae Min Cho Gyiae Yun Jaehwi Lee | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 15 |
| 2 | Phytochrome-lnteracting Factors (PIFs) as Bridges between Environmental Signals and the Circadian Clock: Diurnal Regulation of Growth and Development显示文摘The rotation of the Earth around its axis results in distinct changes in light and temperature during a 24-h day/night cycle.Plants being sessile are constantly and predictably exposed to these environmental changes.It is therefore critical for them to properly perceive environmental signals in order to effectively manage growth and development. | Jieun Shin Muhammad Usman Anwer Seth Jon Davis | 2013 | Molecular Plant2013，6，3： | 8 |
| 3 | Cross-regulation between protein L-isoaspartyl O-methyltransferase and ERK in epithelial mesenchymal transition of MDA-MB-231 cells显示文摘目的: 蛋白质 L-isoaspartyl O-methyltransferase (PIMT ) 通过 integrin α 的激活在各种各样的癌症房间线调整房间粘附; v 和 PI3K 小径。上皮的间充质的转变(EMT ) 使上皮的房间能获得间充质的房间的特征,并且允许他们为转移移居。这里,我们与依附或分开的 MDA-MB 231 房间检验了在 PIMT 和 EMT 之间的关系。 | Jiyeon RYU Jihyeok SONG Jieun HEO Yongwoo JUNG Sang-Jin LEE Sungyoul HONG Jae Youl CHO | 2011 | Acta Pharmacologica Sinica2011，32，9： | 5 |
| 4 | Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma显示文摘Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discriminating CCA from BBD. | Hye Sook Han Mi Jin Kim Joung-Ho Han Jieun Yun Hee Kyung Kim Yaewon Yang Ki Bae Kim Seon Mee Park | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 5 | Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report显示文摘Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract. | Kwangil Yim Sang Mi Ro Jieun Lee | 2017 | World Journal of Gastroenterology2017，23，12： | 2 |
| 6 | Influence of the molecular structure of metal-phthalocyanine on electrocatalytic reactions显示文摘The demand for new catalysts for renewable energy production has become crucial.As an alternative to metal catalysts for electrocatalysis to produce energy sources,metal-phthalocyanine(MPc)electrocatalysts have shown potential.Their physicochemical and electrochemical properties depend on the chemical structure of the MPc and the central metal atom.Recent reviews of MPcs focused on their electrochemical performance in specific catalytic reactions,such as oxygen reduction reaction and CO_(2)reduction reaction.However,understanding the structure of MPcs in depth is important,since their electrochemical catalytic activity is affected by structural modifications of MPcs.Therefore,this minireview focuses on how the molecular structure of MPcs affects electrochemical catalysis. | Da Sol Jeong Hyeon Suk Shin Jieun Yang | 2022 | Science China Materials2022，65，12： | 2 |
| 7 | Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than 6 Months Compared With More Than 6 Months: A 15-Year Prospective Study显示文摘 | Kwang-Hyub Han Do Young Kim Jun Yong Park Sang Hoon Ahn Jieun Kim Seung Up Kim Ja Kyung Kim Kwan Sik Lee Chae Yoon Chon | 2013 | Journal of Clinical Gastroenterology2013，，6： | 1 |
| 8 | Adsorptiveremoval of dimethyl disulfide in olefin rich C4 with ion exchanged zeolites显示文摘 | Lee Jieun Beum Hee Tae Ko Chang Hyun | 2011 | Ind Eng Chem Res2011，50，63： | 1 |
| 9 | Anticancer activity of protoeateehualdehyde in human breast cancer cells 显示文摘 | Choi Jieun Jiang Xiaojing Jeong Jin Boo | 2014 | J Med Food2014，17，8： | 1 |
| 10 | Experimental determination of unsteady aerodynamic coefficients and flutter behavior of a rigid wing显示文摘 | Jieun Song Taehyoun Kim Seung Jin Song | | 0，，： | 1 |
| 11 | Comparison of in vitro hepatogenic differentiation potential between various placenta-derived stem cells and other adult stem cells as an alternative source of functional hepatocytes显示文摘 | Hyun-Jung Lee Jieun Jung Kyung Jin Cho Chang Kyou Lee Seong-Gyu Hwang Gi Jin Kim | 2012 | Differentiation2012，，3： | 1 |
| 12 | Comparison of in vitro hepatogenic differentiation potential between various placenta-derived stem cells and other adult stem cells as an alternative source of functional hepatocytes显示文摘 | Hyun-Jung Lee Jieun Jung Kyung Jin Cho Chang Kyou Lee Seong-Gyu Hwang Gi Jin Kim | 2012 | Differentiation2012，，3： | 1 |
| 13 | Akt stabilizes estrogen receptor α with the concomitant reduction in its transcriptional activity显示文摘 | Sungwoo Park Jieun Song Cheol O Joe Incheol Shin | 2008 | Cellular Signalling2008，，7： | 1 |
| 14 | Experimental determination of unsteady aerodynamic coefficients and flutter behavior of a rigid wing显示文摘 | Jieun S Taehyoun K Seung J | 2012 | Journal of Fluid and Structures2012，，29： | 1 |
| 15 | Do antiplatelets increase the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms?显示文摘 | Joo Hyun Lim Sang Gyun Kim Ji Won Kim Yoon Jin Choi Jieun Kwon Ji Yeon Kim Yun Bin Lee Jeongmin Choi Jong Pil Im Joo Sung Kim Hyun Chae Jung In Sung Song | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 16 | Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1显示文摘 | Yunsoo Park Hwa Sun Ryu Hong Kyung Lee Ji Sung Kim Jieun Yun Jong Soon Kang Bang Yeon Hwang Jin Tae Hong Youngsoo Kim Sang-Bae Han | 2014 | International Immunopharmacology2014，，： | 1 |
| 17 | A nanofilter composed of carbon nanotube-silver composites for virus removal and antibacterial activity improvement显示文摘We have developed a new nanofilter using a carbon nanotube-silver composite material that is capable of efficiently removing waterborne viruses and bacteria.The nanofilter was subjected to plasma surface treatment to enhance its flow rate,which was improved by approximately 62%.Nanoscale pores were obtained by fabricating a carbon nanotube network and using nanoparticle fixation technology for the removal of viruses.The pore size of the nanofilter was approximately 38 nm and the measured flow rate ranged from 21.0 to 97.2 L/(min·m^2)under a pressure of 1–6 kgf/cm^2 when the amount of loaded carbon nanotube-silver composite was 1.0 mg/cm^2.The nanofilter was tested against Polio-,Noro-,and Coxsackie viruses using a sensitive real-time polymerase chain reaction assay to detect the presence of viral particles within the outflow.No trace of viruses was found to flow through the nanofilter with carbon nanotube-silver composite loaded above 0.8 mg/cm^2.Moreover,the surface of the filter has antibacterial properties to prevent bacterial clogging due to the presence of 20-nm silver nanoparticles,which were synthesized on the carbon nanotube surface. | Jun Pyo Kim Jae Ha Kim Jieun Kim Soo No Lee Han-Oh Park | 2016 | Journal of Environmental Sciences2016，28，4： | 1 |
| 18 | Clini- cal characteristics of pulmonary embolism with underlying malig- nancy显示文摘 | JIEUN LEE HYE-RYOUN KIM SANG-MIN LEE | 2010 | Korean J Inter Med2010，25，1： | 1 |
| 19 | Effect of ulinastatin on perioperative organ function and sys- temic inflammatory reaction during cardiac surgery:A randomized double-blinded study显示文摘 | Jieun SongjJungmin Park Jee-Young Kim | 2013 | Korean J Anesthesiol2013，64，4： | 1 |
| 20 | The Role of Oxidative Stress in Neurodegenerative Diseases显示文摘 | Geon H K Jieun E K Sandy JR | 2015 | Experimental Neurobiology2015，24，4： | 1 |
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