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| 1 | A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer显示文摘AIM: Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylon) infection occurs in humans, iNOS Ser^608 Leu allele, a novel genetic polymorphism (C/T) occurring within exon 16 of the iNOS reductase domain, may have a dramatic effect on the enzymatic activity. The aim of this study was to determine whether iNOS C/T polymorphism was associated with increased susceptibility to gastric cancer. METHODS: We conducted a population based case-control study in a high gastric cancer incidence area, Yangzhong, China. Questionnaires from 93 patients with intestinal type gastric cancer (IGC), 50 with gastric cardia cancer (GCC) and 246 healthy controls were obtained between 1997 and 1998, and iNOS genotyping was carried out. Odds ratios (ORs), interaction index (γ), and 95% confidence intervals for the combined effects of iNOS genotype and H pylori infection, cigarette smoking or alcohol drinking were estimated. RESULTS: The frequency of (CT+TT) genotypes was higher in cases than in control group (24.48% vs 23.17%), but the difference was not statistically significant. After adjusting for age and gender, past cigarette smokers with (CT+TT) genotypes had a significantly increased risk of IGC (OR=3.62, 95% CI:1.23-10.64), while past alcohol drinkers with (CT+TT) genotypes had a significantly increased risk of GCC (OR=3.33, 95% CI:1.14-9.67). H pylori CagA negative subjects with (CT+TT) genotypes had a significantly increased risk of both IGC and GCC (OR=2.19 and 3.52, respectively). CONCLUSION: iNOS Ser^608 Leu allele may be a potential determinant of susceptibility to cigarette -alcohol induced gastric cancer, but larger studies are needed to confirm the observations. | JingShen Run-TianWang Li-WeiWang Yao-ChuXu Xin-RuWang | 2004 | World Journal of Gastroenterology2004，10，22： | 12 |
| 2 | E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population显示文摘AIM: To test the hypothesis that E-cadherin gene (CDH1)C-160A promoter variant genotype is associated with an increased risk for developing gastric cancer.METHODS: In this population-based case-control study of gastric cancer in Jiangsu Province, China, we performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to genotype the C-160A polymorphism of CDH1 promoter in 206 non-cardia gastriccancer patients and 261 age- and sex-matched but unrelated cancer-free controls.RESULTS: The frequencies of genotypes CC, CA and AA were 57.8%, 36.4% and 5.8% in gasfric cancer cases,respectively, and 58.2%, 34.9% and 6.9% in controls respectively. The distributions of CDH1 genotypes were not significantly different between gastric cancer cases and controls (P = 0.87 for genotype frequency and P = 0.92for allele frequency). Compared with the CC genotype, the CA and AA genotypes were not associated with an increased risk for non-cardia gastric cancer (adjusted odds ratios (OR)= 1.15, and 95% confidence interval (95% CI) = 0.78-1.72for CA genotype, and OR = 0.90 and 95% CI = 0.42-2.01for AA genotype).CONCLUSION: E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population. | YanLu Yao-Chuxu JingShen Rong-BinYu Ju-YinNiu Jian-TaoGuo XuHu Hong-BingShen | 2005 | World Journal of Gastroenterology2005，11，1： | 8 |
| 3 | Elucidation of “phase difference” in Raman tensor formalism显示文摘The so-called 'phase difference' is commonly introduced as a phenomenological parameter in Raman tensor theory, so as to fit the experimental data well. Although phase difference is widely recognized as an intrinsic property of crystals, its physics still remains ambiguous. Recently, Kranert et al. have presented a new formalism to explain the origin of phase difference theoretically. Here, we systematically conducted experimental research with polar phonons in wurtzite crystals, the results of which strongly suggest that the phase difference should be predetermined in a Raman tensor, rather than be treated as Raman tensor elements traditionally or as an intrinsic property. On the grounds of pinpointing existing logical flaws in Raman tensor study, we provide a logically clear paradigm. | WEI ZHENG JINGSHEN YAN FADI LI FENG HUANG | 2018 | Photonics Research2018，6，7： | 3 |
| 4 | An Overview of Mineral Processing in China显示文摘The latest progress in mineral processing in China is described. It is also pointed out that the existing techno- logy can not meet the needs of economic development. The combined challenges of poor resources, economical benefits and environmental pollution issues require further research to upgrade the separation efficiency economically. The methods of mineral processing should play a more important pod in waste treatment such as wastewater treatment, the re- mediation of contaminated soil and the recycling of wastes. Biomineral technology will be utilised in the near future. | Quanyuan Chen, Jingshen Zhang, Dianzuo Whng (Changsha Research Institute of Mining and Metallurgy, Changsha 410012, China General Research Institute for Nonferrous Metals, Beijing 100088, China) | 2001 | Rare Metals2001，20，2： | 2 |
| 5 | Combination of intraoperative embolisation with surgical resection for treatment of giant cerebral arteriovenous malformations显示文摘 | Shuo W jingshen L | 2000 | J Clin Neurosci2000，7，1： | 1 |
| 6 | Microstructures and fracture behavior of glass-fiber reinforced PBT/PC/E-GMA elastomer blends—1: microstructures显示文摘 | Ke Wang Jingshen Wu Hanmin Zeng | 2001 | Composites Science and Technology2001，，11： | 1 |
| 7 | Strain monitoring in FRP laminates and concrete beams using FBG sensors显示文摘 | Kin-tak Lau Libo Yuan Li-min Zhou Jingshen Wu Chung-ho Woo | 2000 | Composite Structures2000，，1： | 1 |
| 8 | Microstruc tures and fracture behavior of glass-fiber reinforced PBT/PC/E-GMA elastomer blends-l: Nicrostructures 显示文摘 | Wang Ke Wu Jingshen Zeng Hanmin | 2001 | Composites Science and Technology2001，61，11： | 1 |
| 9 | Polypropylene/calcium carbonate nanocomposites 显示文摘 | Chan Chiming Wu Jingshen Li Jianxiong | 2002 | Polym2002，43，10： | 1 |
| 10 | High impact strength epoxy nanocomposites with natural nanotubes显示文摘 | Ye Yueping Chen Haibin Wu Jingshen | 2007 | Polymer2007，48，： | 1 |
| 11 | Mechanical properties and toughening mechanisms of polypropylene/bari- um sulfate composites 显示文摘 | WANG Ke WU Jingshen YE Lin | 2003 | Composites Part A2003，34，： | 1 |
| 12 | Polypropylene/calcium carbonate nanocomposites显示文摘 | Chi-Ming Chan Jingshen Wu Jian-Xiong Li Ying-Kit Cheung | 2002 | Polymer2002，，： | 1 |
| 13 | Polypropylene/calcium carbonate nanocomposite 显示文摘 | Chan Chiming Wu Jingshen Li Jianxiong | 2002 | Polymer2002，43，2： | 1 |
| 14 | Polypropylene/Calcium Carbonate Nanocomposites 显示文摘 | Chi-Ming Chan Jingshen Wu Jian-Xiong Li Ying-Kit Cheung | 2002 | Polymer2002，43，10： | 1 |
| 15 | The toughening mechanism of polypropylene/calcium carbonate nanocomposites 显示文摘 | LIN Yong CHEN Haibin WU Jingshen | 2010 | Polymer2010，51，： | 1 |
| 16 | Combination of intraoperative embolisation with surgical resection for treatment of giant cerebral arteriovenous malformations显示文摘 | Jizong Z Shuo W Jingshen L | 2000 | J Clin Neurosci2000，7，1： | 1 |
| 17 | The dielectric and mechanical properties of apotassium-titanate-whisker-reinforced PP/PA blend显示文摘 | Demei Yua b Jingshen Wu etal | 2000 | Composites Science and Technology2000，60，5： | 1 |
| 18 | Polypropylene/calcium carbonate nanocomposites显示文摘 | Chan Chiming Wu Jingshen Li Jianxiong | 2002 | Polymer2002，43，： | 1 |
| 19 | Polypropylene/Caleium Carbonate Nanocomposites 显示文摘 | Chan Chiming Wu Jingshen Li Jianxiong | 2002 | Polymer2002，43，： | 1 |
| 20 | Preparation of highly ex- foliated epoxy/clay nanocomposites by ' slurry compounding ': process and mechanisms 显示文摘 | Wang Ke Wang Lei Wu Jingshen | 2005 | Langmuir2005，21，8： | 1 |
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