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| 1 | The efficacy assessment of convalescent plasma therapy for COVID-19 patients:a multi-center case series显示文摘Convalescent plasma(CP)transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections.However,the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019(COVID-19).We aimed to explore the potential efficacy of CP therapy,and to assess the possible factors associated with its efficacy.We enrolled eight critical or severe COVID-19 patients from four centers.Each patient was transfused with 200–400mL of CP from seven recovered donors.The primary indicators for clinical efficacy assessment were the changes of clinical symptoms,laboratory parameters,and radiological image after CP transfusion.CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody(NAb)level.No adverse events were observed during and after CP transfusion.Following CP transfusion,six out of eight patients showed improved oxygen support status;chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days;the viral load was decreased to a negative level in five patients who had the previous viremia;other laboratory parameters also tended to improve,including increased lymphocyte counts,decreased C-reactive protein,procalcitonin,and indicators for liver function.The clinical efficacy might be associated with CP transfusion time,transfused dose,and the NAb levels of CP.This study indicated that CP might be a potential therapy for severe patients with COVID-19. | Hao Zeng Dongfang Wang Jingmin Nie Haoyu Liang Jiang Gu Anne Zhao Lixin Xu Chunhui Lang Xiaoping Cui Xiaolan Guo Changlong Zhou Haibo Li Bin Guo Jinyong Zhang Qiang Wang Li Fang Wen Liu Yishan Huang Wei Mao Yaokai Chen Quanming Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 2 | Face recognition by decision fusion of two-dimensional linear discriminant analysis and local binary pattern显示文摘 | Qicong WANG Binbin WANG Xinjie HAO Lisheng CHEN Jingmin CUI Rongrong JI Yunqi LEI | 2016 | Frontiers of Computer Science2016，10，6： | 1 |
| 3 | Obtain the optimal of logistics delivery network with annealing algorithm显示文摘Simulated annealing(SA) algorithm is a heuristic algorithm,proposed one approximation algorithm of solving optimization combinatorial problems inspired by objects in the annealing process of heating crunch. The algorithm is superior to the traditional greedy algorithm,which avoids falling into local optimum and reaches global optimum. There are often some problems to find the shortest path,etc in the logistics and distribution network, and we need optimization for logistics and distribution path in order to achieve the shortest,best,most economical,and so on. The paper uses an example of SA algorithm validation to verify it,and the method is proved to be feasible. | Duan Jingmin Chang Yuejun Li Zanxiang Cui Jianming | 2013 | Engineering Sciences2013，11，6： | 0 |
| 4 | Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-αsignaling显示文摘Background Hepatic inflammation is the major risk factor of hepatocellular carcinoma(HCC).However,the underlying mechanism by which hepatic inflammation progresses to HCC is poorly understood.This study was designed to investigate the role of ETS translocation variant 4(ETV4)in linking hepatic inflammation to HCC.Methods Quantitative real-time PCR and immunoblotting were used to detect the expression of ETV4 in HCC tissues and cell lines.RNA sequencing and luciferase reporter assays were performed to identify the target genes of ETV4.Hepatocyte-specific ETV4-knockout(ETV4fl/fl,alb-cre)and transgenic(ETV4Hep-TG)mice and diethylnitrosamine-carbon tetrachloride(DEN-CCL4)treatment experiments were applied to investigate the function of ETV4 in vivo.The Cancer Genome Atlas(TCGA)database mining and pathological analysis were carried out to determine the correlation of ETV4 with tumor necrosis factor-alpha(TNF-α)and mitogen-activated protein kinase 11(MAPK11).Results We revealed that ETV4 was highly expressed in HCC.High levels of ETV4 predicted a poor survival rate of HCC patients.Then we identified ETV4 as a transcription activator of TNF-αand MAPK11.ETV4 was positively correlated with TNF-αand MAPK11 in HCC patients.As expected,an increase in hepatic TNF-αsecretion and macrophage accumulation were observed in the livers of ETV4Hep-TG mice.The protein levels of TNF-α,MAPK11,and CD68 were significantly higher in the livers of ETV4Hep-TG mice compared with wild type mice but lower in ETV4fl/fl,alb-cre mice compared with ETV4fl/fl mice as treated with DEN-CCL4,indicating that ETV4 functioned as a driver of TNF-α/MAPK11 expression and macrophage accumulation during hepatic inflammation.Hepatocyte-specific knockout of ETV4 significantly prevented development of DEN-CCL4-induced HCC,while transgenic expression of ETV4 promoted growth of HCC.Conclusions ETV4 promoted hepatic inflammation and HCC by activating transcription of TNF-αand MAPK11.Both the ETV4/TNF-αand ETV4/MAPK11 axes represented two potential therapeutic targets for highly associated hepatic inflammation and HCC.ETV4+TNF-αwere potential prognostic markers for HCC patients. | Dandan Qi Min Lu Pengfei Xu Xinli Yao Yongchen Chen Lipeng Gan Yong Li Yahua Cui Xiaomei Tong Shuhong Liu Jingmin Zhao Ningning Liu Xin Ye | 2023 | Cancer Communications2023，43，12： | 0 |
| 5 | THE SIMILARITIES AND DIFFERENCES IN STYLE BETWEEN TW0 NEWS REP0RTS——THE STYLISTIC FEATURES 0F NEWSPAPER REP0RTS显示文摘Different newspapers have different features and styles, which are mainly defined by thesort the paper belongs to. A and B are two treatments of the same event (Southhall tragedyin England) by two different newspapers——The Daily Telegraph and The daily Mirror, theformer being a quality paper in support of the Conservative Party and the latter a popular oneon the side of the Laber Party. There are both similarities and differences in style betweenthe two news reports. | Cui Jingmin | 1996 | 三明学院学报1996，14，1： | 0 |
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