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| 1 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 2 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 3 | Urban Three-dimensional Expansion and Its Driving Forces——A Case Study of Shanghai,China显示文摘Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied to represent city's vertical and horizontal increases respectively,and statistical methods were used to analyze the driving forces of urban expansion.The research drew following conclusions:1) The urban expansion process of Shanghai from 1985 to 2006 had a clear periodic feature,and could be divided into three stages:vertical expansion in dominance,coordinated vertical and horizontal expansion,and horizontal expansion in dominance.2) The average height and quantity of buildings in core city were significantly bigger than those in suburbs,but the changing speed of the latter was faster.And 3) urbanization process was the major driving force for the city's horizontal expansion,while industrial structure improvement was the key driving factor for the vertical expansion.Those two driving forces were simultaneously affected by city's political factors. | SHI Longyu SHAO Guofan CUI Shenghui LI Xuanqi LIN Tao YIN Kai ZHAO Jingzhu | 2009 | Chinese Geographical Science2009，19，4： | 20 |
| 4 | Computing payment for ecosystem services in watersheds: An analysis of the Middle Route Project of South-to-North Water Diversion in China显示文摘Payment for ecosystem services (PES) has attracted considerable attention as an economic incentive for promoting natural resource management recently. As emphasis has been placed on using the incentive-based mechanism by the central government, rapid progress on PES research and practice has been achieved. However PES still faces many difficulties. A key issue is the lack of a fully-fledged theory and method to clearly define the design scope, accounting and feasibility of PES criteria. An improved watershed criteria model was developed in light of research on PES practices in China, investigations on the water source area for the Middle Route Project of South-to-North Water Diversion and ecosystem services outflows theory. The basic principle of assessment is the direct and opportunity cost for ecological conservation and environmental protection in the water source area deduct nationally-financed PES and internal effect. Then the scope and the criteria methods were determined, and internal effect was put forward to define benefits brought from water source area. Finally, Shiyan City, which is the main water source area for the Project of Water Diversion, was analyzed by this model and its payment was calculated. The results showed that: (1) during 2003-2050, the total direct cost and opportunity cost would reach up to 262.70 billion and 256.33 billion Chinese Yuan (CNY, 2000 constant prices), i.e., 50.61% and 49.38% of total cost, respectively; (2) Shiyan City would gain 0.23, 0.06 and 0.03 CNY/m3 in 2014-2020, 2021-2030, and 2031-2050, respectively. | Zhengju Dong Yan Yan Jing Duan Xiao Fu Qingrong Zhou Xiang Huang Xiangen Zhu Jingzhu Zhao | 2011 | Journal of Environmental Sciences2011，23，12： | 12 |
| 5 | Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies显示文摘As compared to permanent orthopedic implants for load-bearing applications, biodegradable orthopedic implants have the advantage of no need for removing after healing, but they suffer from the 'trilemma' problem of compromising among sufficiently high mechanical properties, good biocompatibility and proper degradation rate conforming to the growth rate of new bones. In the present work, in vitro and in vivo studies of a Zn-0.05 wt%Mg alloy(namely, Zn-0.05 Mg alloy) were conducted with pure Zn as a control. The Zn-0.05 Mg alloy is composed of a small amount of Mg_2 Zn11 phase embedded in the refined Zn matrix with an average grain size of ~20 μm. The addition of 0.05 wt% Mg into Zn significantly increases the ultimate tensile strength up to 225 MPa and the elongation to fracture to 26%, but has little influence on the in vitro degradation rate. Both Zn and Zn-0.05 Mg alloy exhibit homogeneous in vitro degradation with a rate of about 0.15 mm/year. Based on the cytotoxicity evaluation, Zn and Zn-0.05 Mg alloy do not induce toxicity to L-929 cells, indicating that they have little toxicity to the general functions of the animal. An in vivo biocompatibility study of Zn and Zn-0.05 Mg alloy samples by placing them in a rabbit model for 4.12 and 24 weeks, respectively did not show any inflammatory cells, and demonstrated that new bone tissue formed at the bone/implant interface, suggesting that Zn and Zn-0.05 Mg alloy promote the formation of new bone tissue. The in vivo degradation of Zn and Zn-0.05 Mg alloy does not bring harm to the important organs and their cell structures. More interestingly, Zn and Zn-0.05 Mg alloy exhibit strong antibacterial activity against Escherichia coli and Staphylococcus aureus. The above results clearly demonstrate that the Zn-0.05 Mg alloy could be a potential biodegradable orthopedic implant material. | Chi Xiao Liqing Wang Yuping Ren Shineng Sun Erlin Zhang Chongnan Yan Qi Liu Xiaogang Sun Fenyong Shou Jingzhu Duan Huang Wang Gaowu Qin | 2018 | Journal of Materials Science & Technology2018，34，9： | 11 |
| 6 | Receptor-interacting Protein 140 Overexpression Promotes Neuro-2a Neuronal Differentiation by ERK1/2 Signaling显示文摘 | Xiao Feng Weidong Yu Rong Liang Cheng Shi Zhuran Zhao Jingzhu Guo | 2015 | Chinese Medical Journal2015，，1： | 5 |
| 7 | THE FUZZY CORE OF SUM-COMPOUND FUZZY GAMES显示文摘In this paper, the model of sum-compound fuzzy game is established, and the fuzzy core of sum-compound fuzzy game is studied. | Zhao Jingzhu~* (Research Center for Eco-Environmental Sciences, Academia Sinica) | 1989 | 中国科学院研究生院学报1989，6，2： | 4 |
| 8 | Cytotoxicity of the soluble and insoluble fractions of atmospheric fine particulate matter显示文摘Inhaled atmospheric fine particulate matter(PM2.5)includes soluble and insoluble fractions,and each fraction can interact with cells and cause adverse effects.PM2.5 samples were collected in Jinan,China,and the soluble and insoluble fractions were separated.According to physiochemical characterization,the soluble fraction mainly contains watersoluble ions and organic acids,and the insoluble fraction mainly contains kaolinite,calcium carbonate and some organic carbon.The interaction between PM2.5 and model cell membranes was examined with a quartz crystal microbalance with dissipation(QCM-D)to quantify PM2.5 attachment on membranes and membrane disruption.The cytotoxicity of the total PM2.5 and the soluble and insoluble fractions,was investigated.Negatively charged PM2.5 can adhere to the positively charged membranes and disrupt them.PM2.5also adheres to negatively charged membranes but does not cause membrane rupture.Therefore,electrostatic repulsion does not prevent PM2.5 attachment,but electrostatic attraction induces remarkable membrane rupture.The human lung epithelial cell line A549 was used for cytotoxicity assessment.The detected membrane leakage,cellular swelling and blebbing indicated a cell necrosis process.Moreover,the insoluble PM2.5 fraction caused a higher cell mortality and more serious cell membrane damage than the soluble fraction.The levels of reactive oxygen species(ROS)enhanced by the two fractions were not significantly different.The findings provide more information to better understand the mechanism of PM2.5 cytotoxicity and the effect of PM2.5 solubility on cytotoxicity. | Ling Liu Qiuhua Zhou Xuezhi Yang Gang Li Jingzhu Zhang Xuehua Zhou Wei Jiang | 2020 | Journal of Environmental Sciences2020，32，5： | 4 |
| 9 | Short-term wind power prediction based on extreme learning machine with error correction显示文摘Introduction:Large-scale integration of wind generation brings great challenges to the secure operation of the power systems due to the intermittence nature of wind.The fluctuation of the wind generation has a great impact on the unit commitment.Thus accurate wind power forecasting plays a key role in dealing with the challenges of power system operation under uncertainties in an economical and technical way.Methods:In this paper,a combined approach based on Extreme Learning Machine(ELM)and an error correction model is proposed to predict wind power in the short-term time scale.Firstly an ELM is utilized to forecast the short-term wind power.Then the ultra-short-term wind power forecasting is acquired based on processing the short-term forecasting error by persistence method.Results:For short-term forecasting,the Extreme Learning Machine(ELM)doesn’t perform well.The overall NRMSE(Normalized Root Mean Square Error)of forecasting results for 66 days is 21.09%.For the ultra-short term forecasting after error correction,most of forecasting errors lie in the interval of[-10 MW,10 MW].The error distribution is concentrated and almost unbiased.The overall NRMSE is 5.76%.Conclusion:The ultra-short-term wind power forecasting accuracy is further improved by using error correction in terms of normalized root mean squared error(NRMSE). | Zhi Li Lin Ye Yongning Zhao Xuri Song Jingzhu Teng Jingxin Jin | 2016 | Protection and Control of Modern Power Systems2016，1，1： | 3 |
| 10 | Reaction path synthesis methodology for waste minimization显示文摘It is a key step for reducing waste generation in chemical processes to design op-timal reaction paths. In this paper, methods of waste minimization for reaction path synthesis problems are proposed to realize eco-industrial production mode with minimum waste emission. A new conception of simple stoichiometric reaction is presented for reaction path synthesis problem. All simple stoichiometric reactions can be obtained by mathematical transformation for atom matrix of a reaction system. Based on the conception, a two-tier optimization method for complex reaction path synthesis problems is addressed. The first step is to determine the eco-nomic optimal overall reactions, and the second step to decompose each overall reaction into several sub-reactions and find out the best thermodynamic feasible reaction path. Further, a method of reaction path synthesis with waste closed-cycle is proposed based on simple stoichiometric reactions for achieving zero waste emission to poly-generation problem of multi-products. Case studies show that the proposed methods can efficiently solve practical re-action path synthesis problems. | HU Shanying LI Mingheng LI Yourun SHEN Jingzhu LIU Zheng | 2004 | Science China Chemistry2004，47，3： | 2 |
| 11 | The effect of gravity on self-similarity of Worthington jet after water entry of a two-dimensional wedge显示文摘The effect of gravity on the self-similarity of jet shape at late stage of Worthington jet development is investigated by experiment in the study.In addition,the particle image velocimetry(PIV)method is introduced to analyze the development of flow field.There is a linear scaling regarding the axial velocity of the jet and the scaling coefficient increases with the Froude number. | Yan Du Jingzhu Wang Zhiying Wang Yiwei Wang | 2023 | Theoretical & Applied Mechanics Letters2023，13，5： | 2 |
| 12 | A NOTE ON THE QUADRILATERAL MESH CONDITION RDP(N,ψ)显示文摘这篇论文的主要目的是证明四边的网孔调节 RDP (N,ψ) 仅仅为在 H^1 标准的 Q_1 isoparametric 元素的最佳的顺序错误估计足够然而并非必要。 | Dongyang Shi Zhong-Ci Shi Jingzhu Wu | 2007 | Journal of Computational Mathematics2007，25，1： | 2 |
| 13 | Eco-Industry: A New Pattern for Industrial Development显示文摘Eco-industry is a new pattern for industrial development. This paper bnefly reviews the progress of eco-industry. The research work of Center for Industrial Ecology, Chemical Engineering Department, Tsinghua University is well introduced. Several academic issues that need further research are suggested from a system engineering point of view. | Li Yourun Hu Shanying Shen Jingzhu Chen Dingjiang(Center for Industrial Ecology, Chemical Engineering Department, Tsinghua University, Beijing 100084) | 2003 | Science Foundation in China2003，11，2： | 2 |
| 14 | A Clustering-Assisted Regression (CAR) approach for developing spatial climate data sets in China显示文摘 | Lina Tang Xiaodan Su Guofan Shao Hao Zhang Jingzhu Zhao | 2012 | Environmental Modelling and Software2012，，： | 1 |
| 15 | Ecological footprint simulation and predication by ARIMA model:a case study in Henan province of China显示文摘 | JIA Junsong ZHAO Jingzhu DENG Hongbing | | 0，，02： | 1 |
| 16 | Strategies for the sustainabledevelopment of Lugu Lake region显示文摘 | Zhao Jingzhu Jia Hongyu | 2008 | International Journal ofSustainable Development&World Ecology2008，，： | 1 |
| 17 | Assessment of Eco-security in the Knowledge Grid E-science Environment显示文摘 | Xiaoqing Shi Jingzhu Zhao Zhiyun Ouyang | 2006 | The Journal of Systems and Software2006，79，2： | 1 |
| 18 | Assessment of eco-security in the Knowledge Grid e-science environment显示文摘 | Xiaoqing Shi Jingzhu Zhao Ouyang Zhiyun | 2006 | The Journal of Systems and Software2006，79，2： | 1 |
| 19 | Impacts of sewage irrigation on heavy metal distribution and contamina- tion in Beijing,China显示文摘 | Liu Wenhua Zhao Jingzhu Ouyang Zhiyun | 2005 | Soil Contamination and Environme- ntal Health2005，6，31： | 1 |
| 20 | Impacts of sewage irrigation on heavy metal distribution and contamination in Beijing, China显示文摘 | Liu Wenhua Zhao Jingzhu Ouyang Zhiyun | 2005 | Environment International2005，31，6： | 1 |
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