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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Structural basis of the Norrin-Frizzled 4 interaction显示文摘 | Guobo Shen Jiyuan Ke Zhizhi Wang Zhihong Cheng Xin Gu Yuquan Wei Karsten Melcher H Eric Xu Wenqing Xu | 2015 | Cell Research2015，25，9： | 3 |
| 3 | Qing Dai, a traditional Chinese medicine for the treatment of chronic hemorrhagic radiation proctitis显示文摘评估戴青的功效和安全的目的(靛青天赋是) ,繁体中文药,在为长期的出血性的放射直肠炎的治疗。有在到 2008 年 1 月的 2005 年 1 月之间的长期的出血性的放射直肠炎的十个病人与戴青一起被对待的方法。戴青在 1.5 g 的剂量口头上地被管理,为 5 连续的天的出价,为二堂功课的每 2 个星期。病人们在每 3 个月上面被跟随。临床的反应和副作用被评估。六个病人显示出的结果分级 0 的直肠的流血的改进 1 在戴青的 1 堂功课以后治疗。四个病人减少了分级 0 的直肠的流血 1 在治疗的 2 堂功课以后。中部的后续时间是 10 个月(范围:6 24 ) 。在后续时期期间, 1 个病人经历了周期性的直肠的流血并且被管理,热门福尔马林轻拍,它控制了症状。没有治疗毒性被观察。结论戴青可以是为长期的出血性的放射直肠炎的安全、有效的治疗。 | Guangjin Yuan Qinghua Ke Xiaoyan Su Jiyuan Yang Ximing Xu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 4 | Methionine synthase A2756G polymorphism and cancer risk:a meta-analysis显示文摘 | Ke Yu Jing Zhang Jiyuan Zhang | 2010 | Eur J Hum Genet2010，18，3： | 1 |
| 5 | Concurrent gemcitabine and cisplatin combined with 3D conformal radiotherapy for stage III non-small cell lung cancer显示文摘对加 cisplatin 的并发的 gemcitabine 的毒性和功效为阶段 III 非小的房间肺癌症(NSCLC ) 与三维的保角的放射疗法相结合的学习客观。有病理地诊断的 NSCLC 的 36 个病人收到了放射疗法和并发的化疗的方法。与 IIIb 有有阶段 IIIa 和 14 个病人的 22 个病人。放射疗法在常规分别被给 60 70 Gy 的一个总数。化疗包括了 gemcitabine (600 mg/m 2) 和 cisplatin (20 mg/m 2), 一次每星期。结果 32 个病人收到了 60 72 Gy 的全部的剂量。二个病人收到了二个病人收到了的 56 Gy 和另外一个 58 Gy。34 个病人 6 星期化疗收到了 4,当二个病人收到了仅仅化疗的 2 个星期时。全面反应率(CR + PR ) ,完全的反应率(CR ) ,部分反应率(PR ) 是 83.3%(30/36 ) , 11.1%(4/36 ) 并且 72.2%(26/36 ) 分别地。中部的后续持续时间是 18.4 个月。1 年、 2 年的全面幸存率是 77.8%(28/36 ) 并且 55.6%(20/36 ) 分别地。为阶段 III 非小的房间肺癌症与三维的保角的放射疗法相结合的结论并发的 gemcitabine 和 cisplatin 有效、很好容忍。孤独术语的结果需要推进学习。 | Qinghua Ke Guoquan Fu Yaowu Bian Daiwen Jiang Jiyuan Yang | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 1 |
| 6 | Radiosensitization by microRNA30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft显示文摘Objective We aimed to observe the radiosensitization effect of mir-30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft and to explore the underlying mechanism.Methods A549 cell lines with either stable upregulation or downregulation of mir-30a-5p,and their negative control,were transfected with lentivirus vectors.These cell lines were used to establish a nude mouse model with subcutaneous lung-cancer xenograft.Each group was randomly divided into irradiated and non-irradiated groups.The radiosensitization effect of mir-30a-5p in vivo was studied by observing xenograft growth trends and tumor weight.The mechanisms involved in this radiosensitization were investigated by detecting expressed radiosensitization-related proteins,using immunohistochemistry and Western blotting.Results The expression level of mir-30a-5p in the lenti-mir-30a-5p group was higher than that in the negative control(lenti-GFP)group and lower in the lenti-inhibitor group(P<0.05).Subcutaneous lung-cancer xenografts in the irradiation group and lenti-mir-30a-5p increased in size slowly;tumors were lighter and tumor inhibition rates were higher than those in the non-irradiation and lenti-GFP groups.In contrast,the opposite of these effects was observed in the lenti-inhibitor group.Immunohistochemistry and Western blotting indicated that ATM protein expression level was lower in the lenti-mir-30a-5p group,with or without irradiation,compared to that in the lenti-GFP group.ATM protein levels were higher in the lenti-inhibitor groups.The phosphorylation level of ATM at residue 1981 was low in the groups without irradiation and increased significantly after irradiation(P<0.05).Moreover,the phosphorylation level was lower in the lenti-mir-30a-5p group and higher in the lenti-inhibitor group than that in the lenti-GFP group after irradiation(P<0.05).Conclusion Mir-30a-5p enhanced the radiosensitivity of nude mice with subcutaneous lung-cancer xenografts by inhibiting ATM phosphorylation. | Yuyan Guo Yingtao Cui Xing Bao Yue Ke Hongtao Ren Jiyuan Pan Liping Song Hongbing Ma | 2022 | Oncology and Translational Medicine2022，8，4： | 0 |
| 7 | 泰素帝和顺铂联合放疗同步治疗中晩期宫颈癌56例的近期疗效分析(英文)显示文摘Objective: The aim of our study was to investigate the early outcome of the taxotere and cisplatin chemoradiotherapy to the advanced cervical cancer. Methods: Fifty-six cases with cervical cancer (FIGO IIb to IVa) were divided randomly into two groups in the oncology hospital of Jingzhou from September 2009 to October 2010, radiotherapy alone (28 cases) and radiation plus chemotherapy (TP) group. There was no difference of radiotherapy between the two groups, the RT + C cases who accepted TP regimen during the radiation, and DDP once weekly injection of vain, according to 20 mg/m2 and taxotere once weekly i.v. according to 35 mg/m2. These regimen were given for 4-5 weeks, and some medicine for vomiting was given to the RT + C cases. Two groups were received an oral medicine MA 160 mg every day during the treatment. Results: The early outcome: the complete remission rate was 64.3% and partial remission rate was 35.7% in RT + C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remission of RT + C group was higher than that of the RT group. There was significant difference between the two groups. In RT + C group, 1-year survive rate was 100.00% (28/28); in RT group, 1-year survive rate was 85.71% (24/28). There was significant difference between the two groups (χ2 = 4.31 > 3.84, P < 0.05). Conclusion: The taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and the adverse effect are raised, but that can be endured. | Qinghua Ke Shiqiong Zhou Wei Du Yong Lei Min Huang Fei Luo Jiyuan Yang | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，7： | 0 |
| 8 | 奈达铂联合甲地孕酮同步放化疗治疗中晚期宫颈癌的近期疗效分析(英文)显示文摘Objective:The aim of this study was to investigate the early outcome of the nedaplatin and megestrol combine chemoradiotherapy to the advanced cervical cancer.Methods:Forty-two cases with cervical cancer (FIGO IIb to IVa) were divided randomly into two groups,radiotherapy alone (RT group:21 cases) and radiation combines chemotherapy (nedaplatin and megestrol) (RT+ C group:21 cases).There was no difference of radiotherapy between the two groups,the RT+ C group accepted nedaplatin injection during the radiation weekly,according to 30 mg/m 2,these regimen were given for 4-5 weeks.This group was received an oral medicine megestrol 160 mg every day during the treatment.Results:The RT+ C group:the complete remission rate was 80.9% (17/21),the partial remission rate was 19.1% (4/21),the effective rate was 100%.The RT group:the complete remission rate was 38.1% (8/21) and partial remission rate was 32.9% (9/21),the effective rate was 81.0%.The total effective rate and complete remission rate of RT+ C group were higher than RT group.There was significant difference between the two groups.The 1-year survival rates respectively were 100% (21/21) in RT+ C group,80.9% (17/21) in RT group.There was statistically significant difference between the two groups (χ2=4.42>3.84,P<0.05).Conclusion:The nedaplatin and megestrol combine chemoradiotherapy can improve the early outcome of the advanced cervical cancer,and the adverse effects was raised,but that can be endured. | Qinghua Ke Shiqiong Zhou Xiaoyan Su Zheng Liu Wentao Zhang Jiyuan Yang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 0 |
| 9 | In vivo study on heparin/poly-L-lysine-copper coating for surface functionalization of ureteral stent显示文摘Polyurethane(PU)ureteral stents are used in clinics to maintain the ureteral patency.Due to biofilm formation and encrustation complications,long-term clinical usage has been limited.It is therefore necessary to develop an effective response to this unmet medical need.A heparin/poly-L-lysine/copper(NPs)coating was developed in our previous work that showed the effect of preventing infection and encrustation in vitro.In this work,a further study was conducted by grafting NPs on clinical ureteral stents that then were implanted into the infectious bladders of Wistar rats to investigate the effects of nanoparticles on bacterial growth and crystal deposition in vivo.It was found that decreased numbers of adherent microbes,urease amount splitting by bacteria,and deposited crystals were observed on the NPs stents with significant differences in comparison with PU stents.Besides,histological analysis showed that the NPs stents decreased the host tissue inflammation in close relation to the decrease biofilm formation and encrustation after 28 days of implantation. | Bukola O.Awonusi Jianzhong Li Hongwei Li Zhenyu Wang Jiyuan Hu Ke Yang Jing Zhao Shi-Changxu | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
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