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| 1 | Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis显示文摘Triptolide(TP),a major active component of Tripterygium wilfordii Hook.F.(TWHF),is used to treat rheumatoid arthritis(RA).However,it has a narrow therapeutic window due to its serious toxicities.To increase the therapeutic index,a new triptolide-loaded transdermal delivery system,named triptolide-loaded liposome hydrogel patch(TP-LHP),has been developed.In this paper,we used a micro-needle array to deliver TP-LHP to promote transdermal absorption and evaluated this treatment on the pharmacokinetics and pharmacodynamics of TP-LHP in a rat model of collagen-induced arthritis(CIA).The pharmacokinetic results showed that transdermal delivery of microneedle TP-LHP yielded plasma drug levels which fit a onecompartment open model.The relationship equation between plasma concentration and time was C=303.59(e 0.064 t e 0.287t).The results of pharmacodynamic study demonstrated that TP-LHP treatment mitigated the degree of joint swelling and suppressed the expressions of fetal liver kinase-1,fetal liver tyrosine kinase-4 and hypoxia-inducible factor-1α in synovium.Other indicators were also reduced by TP-LHP,including hyperfunction of immune,interleukin-1β and interleukin-6 levels in serum.The therapeutic mechanism of TP-LHP might be regulation of the balance between Th1 and Th2,as well as inhibition of the expression and biological effects of vascular endothelial growth factor. | Gui Chen Baohua Hao Dahong Ju Meijie Liu Hongyan Zhao Zhongping Du Jizi Xia | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 10 |
| 2 | Self-standing oxygen-deficient a-MoO_(3-x)nanoflake arrays as 3D cathode for advanced all-solid-state thin film lithium batteries显示文摘Compared with the planar two-dimensional(2D)all-solid-state thin film batteries(TFBs),threedimensional(3D)all-solid-state TFBs with interdigitated contact between electrode and electrolyte possess great advantage in achieving both high energy and power densities.Herein,we report a facile fabrication of vertically aligned oxygen-deficient a-MoO3-x nanoflake arrays(3D MO_(x))using metal Mo target by direct current(DC)magnetron sputtering.By utilizing the 3D MO_(x)cathode,amorphous lithium phosphorus oxynitride solid electrolyte,and lithium thin film anode,3D solid-state TFBs have been successfully fabricated,exhibiting high specific capacity(266 mAh g^(-1)at 50 mA g^(-1)),good rate performance(110 mAh g^(-1)at 1000mA g^(-1)),and excellent cycle performance(92.7%capacity retention after 1000 cycles)in comparison with the 2D TFBs using the planar MO_(x)thin film as cathode.The superior electrochemical performance of the 3D TFBs can be attributed to the 3D architecture of the cathode,maximizing the cathode/electrolyte interface while retaining the short Lit diffusion length.The charge/discharge measurements of the 3D MO_(x)cathode in liquid electrolyte,however,exhibit fast capacity fading,demonstrating the advantage of using transition metal oxide as cathode in solid-state batteries. | Shuo Sun Qiuying Xia Jizi Liu Jing Xu Feng Zan Jili Yue Serguei V.Savilov Valery V.Lunin Hui Xia | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 3 | Cryogenic treatment induced hardening for Cu-Zr-Ag-Al bulk metallic glasses显示文摘Little is known about the mechanical properties of bulk metallic glassy alloys(BMGs) after cryogenic treatment.In this study,the effects of cryogenic treatment(CT) on the microstructural transition and the mechanical properties of Cu-based bulk metallic glass(BMG) were studied.The results showed that submicron AlCu2Zr and Cu5Zr phases can precipitate from the Cu-Zr-Ag-Al matrix after 192 h CT.The formation of these nanometer-sized crystalline phases substantially enhanced the mechanical properties of the bulk amorphous alloy.The micro-hardness and the compressive strength were found to increase respectively from 501 HV and 1510 MPa to 595 HV and 1910 MPa after cryogenic treatment.CT is a promising approach to strengthening metal glasses. | CHEN ZhenHua ZHANG LiKe LIU JiZi CHEN Ding | 2013 | Chinese Science Bulletin2013，58，7： | 5 |
| 4 | Order Selection and Capacity Planning in MCS with Chain-to-Chain Collaboration显示文摘Due to rejecting order in a single supply chain for lack of adequate capacity, a multi-chain system is introduced to avoid this potential operational risk. Based on four categories of order: direct order, reserve order, chain-to-chain order and rejected order, the framework of order selection in multi-chain system(MCS) is presented, and the model of order selection and planning under chain-to-chain collaboration is formulated. Then, the Lagrange algorithm is used to solve this problem through Lagrange relaxation and decomposition. Finally, numerical study show that opportunity cost of rejecting reserve order and production cost of chain-to-chain order have significant impacts on order selection, and there exists a critical threshold value of the combination of two factors. Through the combination, the multi-chain system can obtain the optimal status, meanwhile manager can utilize this to realize different strategies in MCS. | LI Jizi CHEN Ting LI Xianxin LIU Chunling | 2017 | Wuhan University Journal of Natural Sciences2017，22，6： | 0 |
| 5 | Relationship Between the Strengthening Effect and the Morphology of Precipitates in Al–7.4Zn–1.7Mg–2.0Cu Alloy显示文摘The morphological evolution of the precipitates in Al–7.4Zn–1.7Mg–2.0Cu(wt%) alloy was studied by highresolution transmission electron microscopy(HRTEM). Statistics reveal that the hardness of the alloy changes accordingly with the change of the average thickness–diameter ratio of precipitates. The GPII zones are mainly responsible for the first and also the highest hardness peak. They grow in diameter and keep 7-atomic-layer in thickness. Once the thickness changes, the phase transformation from GPII zone to g0 or g-precursor would occur. The resultant metastable g0 and g-precursor precipitates grow in both diameter and thickness, but much faster in the former. After the first hardness peak,the metastable g0 precipitates and g-precursor, coexisting with part of GPII zones, are counted as the main hardening precipitates. | Xiubo Yang Jizi Liu Jianghua Chen Caiyun Wan Lei Fang Ping Liu Cuilan Wu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，6： | 0 |
| 6 | Excellent strength-ductility combination of Cr_(26)Mn_(20)Fe_(20)Co20Ni_(14) high-entropy alloy at cryogenic temperatures显示文摘In the present study,a face-centered cubic non-equiatomic Cr_(26)Mn_(20)Fe_(20)Co20Ni_(14) high-entropy alloy(HEA)with a low stacking fault energy of 17.6 mJ m^(−2) was prepared by vacuum induction melting,forging and annealing processes.The recrystallized sample is revealed to exhibit an excellent combination of strength and ductility over a wide temperature range of 4.2–293 K.With decreasing temperature from 293 to 77 K,the ductility and ultimate tensile strength(UTS)gradually increase by 30% to 95% and 137% to 1020 MPa,respectively.At the lowest temperature of 4.2 K,the ductility keeps 65% and the UTS increases by 200% to 1300 MPa,which exceed those published in the literature,including conventional 300 series stainless steels.Detailed microstructural analyses of this alloy reveal a change of deformation mechanisms from dislocation slip and nano-twinning at 293 K to nano-phase transformation at 4.2 K.The cooperation and competition of multiple nano-twinning and nano-phase transformation are responsible for the superior tensile properties at cryogenic temperatures.Our study provides experimental evidence for potential cryogenic applications of HEAs. | Xuzhou Gao Wei Jiang Yiping Lu Zhigang Ding Jizi Liu Wei Liu Gang Sha Tongming Wang Tingju Li Isaac T.H.Chang Yonghao Zhao | 2023 | Journal of Materials Science & Technology2023，，23： | 0 |
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