| 1 | CRISPR-Cas9 System:a Revolutionary Tool in the Fight Against Antimicrobial Resistance:Retracted显示文摘The rapidly evolving world of antimicrobial resistance has not only made it difficult to combat infectious diseases,but during the last decades also brought the discovery of novel antimicrobials to a standstill.In recent years,researchers discovered the potential of the clustered regularly interspaced short palindromic repeats(CRISPR)-associated(CRISPR-Cas)system as an alternative therapeutic.Since the unearthing of CRISPR-Cas9 as an“adaptive immune system”of bacteria,the CRISPR-Cas9 system has been improved into a state-of-the-art genetic engineering tool,with an impressive ability to cause specific gene insertions and/or gene deletions,in almost all microorganisms.The emerging picture suggests that the CRISPR-Cas9 system can be exploited in a sequence-specific manner to selectively eliminate individual bacterial strains in a mixed microbial population,and/or re-sensitize bacteria to antibiotics.These findings have not only revolutionized biomedical research,but might also prove to be pivotal in creating novel alternative treatments for multidrug-resistant infections.Here,we discussed the up-to-date findings reported in this area,as well as the approaches involved in the utilization of CRISPR-Cas9 as a novel technology in the fight against antimicrobial resistance.We also highlighted recent studies that have exploited the CRISPR-Cas9 system in the context of targeting pathogenic and drug-resistant bacteria. | Osmond C.Ekwebelem Job Aleke Ekenedirichukwu Ofielu Obinna Nnorom-Dike | 2021 | Infectious Microbes & Diseases2021，3，2： | 0 |
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