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| 1 | Differentiation of isolated wheat zygotes into embryos and normal plants显示文摘 | Jochen Kumlehn Horst L?rz Erhard Kranz | 1998 | Planta1998，，3： | 1 |
| 2 | Arterilization of the portal vain in orthotopic and auxiliary liver transplantation显示文摘 | Jochen Erhard Reinhard Lange Rainer Giebler | 1995 | Transplantation1995，60，： | 1 |
| 3 | Serum bile acids in liver transplantation – early indicator for acute rejection and monitor for antirejection therapy显示文摘 | H. Jan?en Reinhard Lange Jochen Erhard Giuliano Testa Massimo Malagó Petra Jan?en Friedrich W. Eigler Christoph E. Broelsch | 2001 | Transplant International2001，，6： | 1 |
| 4 | Serum bile acids in liver transplantation – early indicator for acute rejection and monitor for antirejection therapy显示文摘 | H. Jan?en Reinhard Lange Jochen Erhard Giuliano Testa Massimo Malagó Petra Jan?en Friedrich W. Eigler Christoph E. Broelsch | 2001 | Transplant International2001，，6： | 1 |
| 5 | Population structure, genetic diversity and linkage disequilibrium in elite winter wheat assessed with SNP and SSR markers显示文摘 | Tobias Würschum Simon M. Langer C. Friedrich H. Longin Viktor Korzun Eduard Akhunov Erhard Ebmeyer Ralf Schachschneider Johannes Schacht Ebrahim Kazman Jochen C. Reif | 2013 | Theoretical and Applied Genetics2013，，6： | 1 |
| 6 | Monitoring individual development of isolated wheat zygotes: a novel approach to study early embryogenesis显示文摘 | Jochen Kumlehn Horst L?rz Erhard Kranz | 1999 | Protoplasma (-)1999，，1： | 1 |
| 7 | Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis显示文摘 | J?rg Heller * Michael Schepke * Nina Gehnen * Gerhard J. Molderings ? Andreas Müller § Jochen Erhard ∥ Ulrich Spengler * Tilman Sauerbruch * | 1999 | Gastroenterology1999，，2： | 1 |
| 8 | Differentiation of isolated wheat zygotes into embryos and normal plants显示文摘 | Jochen Kumlehn Horst Loèrz Erhard Kranz | 1998 | Planta1998，205，： | 1 |
| 9 | K_(2P)18.1 translates T cell receptor signals into thymic regulatory T cell development显示文摘It remains largely unclear how thymocytes translate relative differences in T cell receptor(TCR)signal strength into distinct developmental programs that drive the cell fate decisions towards conventional(Tconv)or regulatory T cells(Treg).Following TCR activation,intracellular calcium(Ca^(2+))is the most important second messenger,for which the potassium channel K_(2P)18.1 is a relevant regulator.Here,we identify K_(2P)18.1 as a central translator of the TCR signal into the thymus-derived Treg(tTreg)selection process.TCR signal was coupled to NF-κB-mediated K_(2P)18.1 upregulation in tTreg progenitors.K_(2P)18.1 provided the driving force for sustained Ca^(2+) influx that facilitated NF-κB-and NFAT-dependent expression of FoxP3,the master transcription factor for Treg development and function.Loss of K_(2P)18.1 ion-current function induced a mild lymphoproliferative phenotype in mice,with reduced Treg numbers that led to aggravated experimental autoimmune encephalomyelitis,while a gain-of-function mutation in K_(2P)18.1 resulted in increased Treg numbers in mice.Our findings in human thymus,recent thymic emigrants and multiple sclerosis patients with a dominant-negative missense K_(2P)18.1 variant that is associated with poor clinical outcomes indicate that K_(2P)18.1 also plays a role in human Treg development.Pharmacological modulation of K_(2P)18.1 specifically modulated Treg numbers in vitro and in vivo.Finally,we identified nitroxoline as a K_(2P)18.1 activator that led to rapid and reversible Treg increase in patients with urinary tract infections.Conclusively,our findings reveal how K_(2P)18.1 translates TCR signals into thymic T cell fate decisions and Treg development,and provide a basis for the therapeutic utilization of Treg in several human disorders. | Tobias Ruck Stefanie Bock Steffen Pfeuffer Christina B.Schroeter Derya Cengiz Paul Marciniak Maren Lindner Alexander Herrmann Marie Liebmann Stjepana Kovac Lukas Gola Leoni Rolfes Marc Pawlitzki Nils Opel Tim Hahn Udo Dannlowski Thomas Pap Felix Luessi Julian A.Schreiber Bernhard Wunsch Tanja Kuhlmann Guiscard Seebohm Bjorn Tackenberg Patricia Seja Frank Doring Erhard Wischmeyer Achmet Imam Chasan Johannes Roth Luisa Klotz Gerd Meyer zu Hörste Heinz Wiendl Tobias Marschall Stefan Floess Jochen Huehn Thomas Budde Tobias Bopp Stefan Bittner Sven G.Meuth | 2022 | Cell Research2022，32，1： | 1 |
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