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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | 独特性之后:法庭科学意见的演进显示文摘法庭科学正在发生巨变,尤其是对从事指纹、鞋印、刀痕、笔迹及诸如此类图形比对的鉴定专家们而言。司法鉴定人正在以新的方式得出结论,并在改变他们报告和证言中所使用的语言。本文解释了这些变化,及其给律师和法官们带来的挑战。 | William C. Thompson Joelle Vuille Franco Taroni Alex Biedermann 汪诸豪(译) | 2018 | 证据科学2018，26，4： | 11 |
| 3 | Optimum chemotherapy in the management of metastatic pancreatic cancer显示文摘Pancreatic cancer is one of the most devastating solid tumors,and it remains one of the most difficult to treat.The treatment of metastatic pancreatic cancer(MPC)is systemic,based on chemotherapy or best supportive care,depending on the performance status of the patient.Two chemotherapeutical regimens have produced substantial benefits in the treatment of MPC:gemcitabine in 1997;and FOLFIRIONOX in 2011.FOLFIRINOX improved the natural history of MPC,with overall survival(OS)of 11.1 mo.Nab-paclitaxel associated with gemcitabine is a newly approved regimen for MPC,with a median OS of 8.6 mo.Despite multiple trials,this targeted therapy was not efficient in the treatment of MPC.Many new molecules targeting the proliferation and survival pathways,immune response,oncofetal signaling and the epigenetic changes are currently undergoing phaseⅠandⅡtrials for the treatment of MPC,with many promising results. | Marwan Ghosn Hampig Raphael Kourie Fadi El Karak Colette Hanna Joelle Antoun Dolly Nasr | 2014 | World Journal of Gastroenterology2014，20，9： | 7 |
| 4 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 5 | 变形链球菌AgⅠ/Ⅱ蛋白编码可变区(Ⅴ+)基因表达质粒的构建显示文摘目的 构建变形链球菌 (S .mutans血清型f、s .mutnas血清型c)表面蛋白编码Ⅴ +基因重组质粒pCVc、pCVf和重组表达质粒pSRVc、pSRVf。 方法 用PCR方法从sr基因中扩增目的基因片段与质粒 pCR2 .1连接 ,再将Ⅴ +区基因片段转移到高效表达质粒pET2 1a(+) ,酶切电泳检测。结果 PCR扩增产物为 1.16kb的DNA带 ,测序结果与sr基因序列Ⅴ +区一致。酶切电泳证实Ⅴ +区基因片段整合到 pET2 1a(+)的适当部位 ,构建重组表达质粒 pSRVc、pSRVf。 结论 本试验成功地构建了携带Ⅴ +基因片段的表达质粒 pSRVc、pSRVf。 | 甘晓榕 Michel-Angelo Sciotti Joelle A.Ogier | 2002 | 现代口腔医学杂志2002，16，4： | 4 |
| 6 | Role of chemotherapy in prostate cancer显示文摘 | Rita Nader Joelle El Amm Jeanny B Aragon-Ching | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
| 7 | Anal cancer treatment:Current status and future perspectives显示文摘Anal cancers(AC)are relatively rare tumors.Their incidence is increasing,particularly among men who have sex with other men due to widespread infection by human papilloma virus.The majority of anal cancers are squamous cell carcinomas,and they are treated according to stage.In local and locally advanced AC,concomitant chemoradiation therapy based on mitomycin C and 5-Fluorouracil(5-FU)is the current best treatment,while metastatic AC,chemotherapy with 5-FU and cisplatin remains the gold standard.There are no indications for induction or maintenance therapies in locally advanced tumors.Many novel strategies,such as targeted therapies,vaccination,immunotherapy and photodynamic therapy are in clinical trials for the treatment of AC,with promising results in some indications. | Marwan Ghosn Hampig Raphael Kourie Pamela Abdayem Joelle Antoun Dolly Nasr | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 8 | Specific Cx43 phosphorylation events regulate gap junction turnover in vivo显示文摘 | Joell L. Solan Paul D. Lampe | 2014 | FEBS Letters2014，，： | 3 |
| 9 | Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis(Coss. & Dur.) Maire显示文摘Objective:To investigate the chemical composition of a moderately polar extract(CHC1_3 soluble part of the MeOH-H_2O extract) obtained from the aerial parts(leaves and flowers) of Centaurea diluta Ait.subsp.algeriensis(Coss.& Dur.) Maire,a species endemic to Algeria and Morocco on which no reports are available to date.To evaluate in vitro the cytotoxic,antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary metabolites.Methods:The cytotoxic effects of the extract were investigated on 3 human cancer cell lines i.e.the A549 non-small-cell lung carcinoma(NSCLC),the MCF7 breast adenocarcinoma and the U373 glioblastoma using a MTT colorimetric assay.Biological data allowed to guide the fractionation of the extract by separation and purification on silica gel 60(CC and TLC).The isolated compounds which were characterized by spectral analysis,mainly HR-ESIMS,HR-EIMS,UV and NMR experiments(~1H,^(13)C,COSY,ROESY,HSQC and HMBC) and comparison of their spectroscopic data with those reported in the literature,were evaluated for cytotoxic activities on six cancer cell lines(A549,MCF7,U373,Hs683 human glioma,PC3 human prostate and B16-F10 murine melanoma).The direct and indirect antibacterial and antifungal activities were determined using microdilution methods for the raw extract and TLC-bioautography and microdilution methods against standard and clinical strains for the isolated compounds.Results:The raw extract reduced cell viability with IC_(50)s of 27,25 and 21 μg/mL on A549,MCF7 and U373,respectively.Five secondary metabolites:two phenolic compounds(vanillin 1,paridol 3),a lignan[(-)-arctigenin 2]and two flavonoid aglycones(eupatilin 4 and jaceosidin 5),were then isolated from this extract.Moderate cytotoxic effects were observed for(-)-arctigenin 2(IC_(50)s:28 and 33μM on Hs683 and B16-F10,respectively),eupatilin 4(IC_(50)s:33 and 47 μM on B16-F10 and PC3,respectively) and jaceosidin 5(IC_(50)s:32 and 40 μM on PC3 and B16-F10,respectively).Conclusions:All the isolated compounds were described for the first time from this species.Although inactive against 7 tested microorganisms(fungi,bacteria and yeast,human or plant pathogens),the raw extract was able to potentiate the effect of beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus(MRSA),reducing the minimal inhibitory concentrations(MICs) by a factor of 2-32-fold.No synergy was found between the extract and streptomycin.From the five isolated compounds only jaseosidin 5 showed a moderate antimicrobial activity. | Hanene Zater Joelle Huet Veronique Fontaine Samir Benayache Caroline Stevigny Pierre Duez Fadila Benayache | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，6： | 2 |
| 10 | 变形链球菌表面蛋白可变区(V+)基因克隆与表达显示文摘目的 分离变形链球菌表面蛋白可变区 (V +)基因 ,构建V +表达克隆。方法 用PCR从sr基因中扩增目的基因片段V(+) ,亚克隆入中间载体 pCR2 1和表达载体 pET2 1a(+)。对重组体进行诱导表达并对表达产物进行SDS -PAGE和Westernblotting分析。 结果 PCR扩增产物为 1 16kb的DNA带 ,亚克隆入载体 ,获得重组克隆pCVf和重组表达克隆pSRVf,表达产物为 4 3kDa抗原 ,可以被抗Ⅰ /Ⅱ抗体特异性地识别。结论 本试验成功地构建了携带V +基因片段的表达克隆pSRVf。 | 甘晓榕 王小琴 Michel-Angelo Sciotti Joelle A.Ogier | 2002 | 中国公共卫生2002，18，5： | 2 |
| 11 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 12 | Semiautomated 3D Root Segmentation and Evaluation Based on X-Ray CT Imagery显示文摘Background.Computed X-ray tomography(CTX)is a high-end nondestructive approach for the visual assessment of root architecture in soil.Nevertheless,in order to evaluate high-resolution CTX data of root architectures,manual segmentation of the depicted root systems from large-scale volume data is currently necessary,which is both time consuming and error prone.The duration of such a segmentation is of importance,especially for time-resolved growth analysis,where several instances of a plant need to be segmented and evaluated.Specifically,in our application,the contrast between soil and root data varies due to different growth stages and watering situations at the time of scanning.Additionally,the root system itself is expanding in length and in the diameter of individual roots.Objective.For semiautomated and robust root system segmentation from CTX data,we propose the RootForce approach,which is an extension of Frangi’s“multi-scale vesselness”method and integrates a 3D local variance.It allows a precise delineation of roots with diameters down to severalμm in pots with varying diameters.Additionally,RootForce is not limited to the segmentation of small below-ground organs,but is also able to handle storage roots with a diameter larger than 40 voxels.Results.Using CTX volume data of full-grown bean plants as well as time-resolved(3D+time)growth studies of cassava plants,RootForce produces similar(and much faster)results compared to manual segmentation of the regarded root architectures.Furthermore,RootForce enables the user to obtain traits not possible to be calculated before,such as total root volume(Vroot),total root length(Lroot),root volume over depth,root growth angles(θmin,θmean,andθmax),root surrounding soil density Dsoil,or form fraction F.Discussion.The proposed RootForce tool can provide a higher efficiency for the semiautomatic high-throughput assessment of the root architectures of different types of plants from large-scale CTX.Furthermore,for all datasets within a growth experiment,only a single set of parameters is needed.Thus,the proposed tool can be used for a wide range of growth experiments in the field of plant phenotyping. | Stefan Gerth Joelle Claußen Anja Eggert Norbert Wörlein Michael Waininger Thomas Wittenberg Norman Uhlmann | 2021 | Plant Phenomics2021，3，1： | 2 |
| 13 | Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation显示文摘A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time.A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction condition.The transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities(86%-99% ee,s factor up to 1057). | Baohua Cai Qingjing Yang Ling Meng Jun(Joelle)Wang | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 14 | Genetic diversity among alfalfa (Medicago sativa ) cultivars coming from a breeding program, using SSR markers显示文摘 | Sandrine F Joelle R Pierre B | 2005 | Theoretical and Applied Genetics2005，111，： | 1 |
| 15 | Neurobiology and clinical pharmacology of obsessive-compulsive disorder 显示文摘 | Joelle Micallef Olivier Blin | 2001 | Clin Neuropharmacology2001，24，4： | 1 |
| 16 | Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV显示文摘 | Catherine Daniel Florent Sebbane Sabine Poiret Denise Goudercourt Joelle Dewulf Chantal Mullet Michel Simonet Bruno Pot | 2008 | Vaccine2008，，8： | 1 |
| 17 | Preterm premature rupture of membranes: is there an optimal gestatianal age for delivery? 显示文摘 | Joelle M Lieman MD Cynthia G | 2005 | 105(1): 12 -172005，105，1： | 1 |
| 18 | Retinol binding protein 4 and prediction of incident coro-nary events in healthy men and women显示文摘 | ZIAD MALLAT TABASSOME SIMON JOELLE BENESSIANO | 2008 | J Clin EndocrinMetab2008，1210，10： | 1 |
| 19 | A new mechanistic approach to simulating swelling processes in bentonite materials显示文摘 | Mingliang Xie Wenqing Wang Joelle De Jonge and Olaf Kolditz | 2003 | Rockflow Preprint2003，，： | 1 |
| 20 | Design of multiple impeller stirred tanks for the mixincl of hiclhlv viscous fluids usincl CFD显示文摘 | Joelle Aubin Catherine Xuereb | 2006 | Chemical Engineerincl Science2006，，61： | 1 |
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