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| 1 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | Enforcing Emissions Trading when Emissions Permits are Bankable显示文摘 | John K. Stranlund Christopher Costello Carlos A. Chávez | 2005 | Journal of Regulatory Economics2005，，2： | 2 |
| 4 | Attentional and memory bias in persecutory delusions and depression显示文摘 | Taylor JL John CH | 2004 | Psychopathology2004，37，5： | 1 |
| 5 | A micromachined high- X-band resonator显示文摘 | CHENG J CH Linda P B | 1997 | IEEE Microwave and Guided Wave Letters1997，7，6： | 1 |
| 6 | Value of bronchial artery embolisation with platinum coils in tumorous pulmonary bleeding显示文摘 | Ch Witt B Schmidt A Geisler A.C Borges M John I Fietze P Romaniuk | 2000 | European Journal of Cancer2000，，15： | 1 |
| 7 | Coronary artery bypass graft pateney: assessment with true fast imaging with steady-state precession versus gadolinium-enhanced MR angiography显示文摘 | BUNCE NH LORENZ CH JOHN AS | 2003 | Radiology2003，227，2： | 1 |
| 8 | Role of p38 MAP kinase in postcapillary venule leukocyte adhesion induced by ischemia/repeffusion injury显示文摘 | johns DG Willelte RN Macphee CH | 2005 | Pharmacol Res2005，51，5： | 1 |
| 9 | Attentional and memory bias in persecutory delusions and depression显示文摘 | Taylor JL John CH | 2004 | Psychopathology2004，37，5： | 1 |
| 10 | Expression pattern of metallothioneio, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish ( Danio rerio) induced by zinc and cadmium显示文摘 | Chen WY John JA Lin CH | 2007 | Environ Toxicol Chem2007，26，1： | 1 |
| 11 | Expression pattern ofmetallothionein, MTF-1 nuclear translocation, and itsdna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium显示文摘 | ChenW Y John J A Lin CH | 2007 | Environ Toxicol Chem2007，26，1： | 1 |
| 12 | Attentional and memory bias in persecutory delusions and depression 显示文摘 | Taylor JL John CH | 2004 | Psychopathology2004，37，5： | 1 |
| 13 | Randomized,double-blind,placebo-controlled trial of intravenous Ketamine in acute asthma显示文摘 | Joseph CH John R Scott D | 1996 | Ann Eerg Med1996，27，： | 1 |
| 14 | Offene versus retroperitoneal skopische Adrenalektomien显示文摘 | Seiler D Padevit CH John H | 2002 | UrologeA2002，41，1： | 1 |
| 15 | Attentional and memory bias in persecutory delusions and depression显示文摘 | Taylor JL John CH | | 0，，： | 1 |
| 16 | The choice of policy instruments to control pollution under costly enforcement and incomplete information显示文摘 | Carlos A. Chávez Mauricio G. Villena John K. Stranlund | 2009 | Journal of Applied Economics2009，，2： | 1 |
| 17 | The optimal pricing of pollution when enforcement is costly显示文摘 | John K. Stranlund Carlos A. Chávez Mauricio G. Villena | 2009 | Journal of Environmental Economics and Management2009，，2： | 1 |
| 18 | Randomized,double blind, placebo-controlled trial of intravenous ketamine in acute asthma显示文摘 | Joseph CH John R Scott D | 1996 | Ann Emerg Med1996，27，： | 1 |
| 19 | Image super-resolution via sparse representation显示文摘 | YANG J CH JOHN W HUANG T S | | 0，，11： | 1 |
| 20 | A novel, simple meth- od of functional spleen volume caculation by liver - spleen scan显示文摘 | John CH Felix WW David LL etal | 1999 | J Nucl Med1999，40，10： | 1 |
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