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| 1 | Taxonomic status and distribution of Mirabilis himalaica (Nyctaginaceae)显示文摘Mirabilis himalaica (Edgew.) Heimerl (Nyctaginaceae) is endemic to the Himalayas where it is used in traditional Tibetan folk medicine and is the only Old World representative of a large New World genus. The systematic position of M. himalaica and historical biogeography of Mirabilis and related genera was evaluated using two loci (nuclear ribosomal internal transcribed spacer, rps16), with divergence times estimated using internal transcribed spacer sequences. All 16 sampled provenances of M. himalaica formed a strongly supported terminal clade and at the sectional level formed a clade with sect. Quamoclidion sensu stricto, despite their morphology. Section Oxybaphoides and sect. Oxybaphus were not closely related to M. himalaica, suggesting their apparent morphological similarities are convergent. The beast analysis and ancestral area reconstruction indicated that M. himalaica separated from related North American species during the late Miocene to early Pleistocene -5.22 Ma (95% highest posterior density, 2.53–8.18). Both migration by way of the Quaternary Bering land bridge (Beringia) and long-distance dispersal could have contributed to the present-day disjunction between M. himalaica and the American species. These results agree with previous studies that suggest Oxybaphus should be merged into Mirabilis. However, although the infrageneric position of M. himalaica is still uncertain, it is not close to sect. Oxybaphus as has been suggested previously. | Shu-Li Wang Lang Li Xiu-Qin Ci John G.Conran Jie Li | 2019 | Journal of Systematics and Evolution2019，57，5： | 2 |
| 2 | Reversing click polarity may uncover auditory neuropathy in infants 显示文摘 | Berlin CI Bordelon J St John P | 1998 | Ear Hear1998，19，： | 1 |
| 3 | High-mobility group box-1 in ischemia- reperfusion injury of the heart 显示文摘 | Martin A Hans CV John CI | 2008 | Circulation2008，117，： | 1 |
| 4 | lntegrated core-log petrofa- of a reservoir geomodel: A case study of a mature Mississippian carbonate reservoir using limited data显示文摘 | Saibal B John H D Timothy R C cies analysis in the construction el al | 2005 | AAPG Bulletin2005，89，3： | 1 |
| 5 | Reversing click po- larity may uncover auditory neuropathy in infants显示文摘 | Berlin CI Bordelon J St John P | 1998 | Ear Hear1998，19，： | 1 |
| 6 | Reverse click polarity may uncover auditory neuropathy in infants显示文摘 | Berlin CI Bordelon J St John P | 1998 | Ear and Hearing1998，19，： | 1 |
| 7 | Central venous pressure or pulmonary capillarywedge pressure as the determinant of fluid replacement in aortic surgery显示文摘 | Rice CI Hobelman CF John FA | 1978 | Surgery1978，84，： | 1 |
| 8 | Reversing click polarity may uncover auditory neuropathy in infants显示文摘 | Berlin CI Bordelon J St John P | 1998 | Ear Hear1998，19，： | 1 |
| 9 | Comparative phylogenetic analyses of Chinese Horsfieldia(Myristicaceae)using complete chloroplast genome sequences显示文摘The biologist's ruler for biodiversity is the species;accurate species identification is fundamental to the conservation of endangered species and in-depth biological scientific exploration.However,the delimitation and affinities of Horsfieldia in China has been controversial,owing in part to very low levels of molecular divergence within the family Myristicaceae.Because species boundaries and phylogenetic relationships within Horsfieldia are also unclear,13 samples were collected across its distribution in China and their genomes were subjected to shotgun sequencing using Illumina platforms.A total of 40487994–84801416 pair-end clean reads were obtained and,after assembly,the complete chloroplast genome was recovered for all samples.Annotation analysis revealed a total of 112 genes,including 78 protein-coding genes,30 transfer RNA,and 4 ribosomal RNA genes.Six variable loci(petN-psbM,trnH-psbA,ndhC-trnV,psbJ-psbL,ndhF,and rrn5-rrn23)were identified.Phylogenetic analyses strongly support the presence of four distinct species of Horsfieldia in China.In addition,samples that had been identified previously as Horsfieldia kingii(Hook.f.)Warb.were indistinguishable from those of H.prainii(King)Warb.,suggesting that if H.kingii does occur in China,it was not collected in this study.Similarly,the chloroplast genome of one H.hainanensis Merr.sample from Guangxi province was identical to H.tetratepala C.Y.Wu,suggesting that the distribution range of H.hainanensis might be narrower than assumed previously.The phylogenetic relationships between the Chinese Horsfieldia species based on the whole chloroplast genomes was supported strongly,indicating the potential for using entire chloroplast genomes as super-barcodes for further resolution of the phylogeny of the genus Horsfieldia. | Chao-Nan Cai Hui Ma Xiu-Qin Ci John G.Conran Jie Li | 2021 | Journal of Systematics and Evolution2021，59，3： | 0 |
| 10 | Chimeric antigen receptors:On the road to realising their full potential显示文摘Chimeric antigen receptors(CARs) are fusion molecules that may be genetically delivered ex-vivo to T-cells and other immune cell populations,thereby conferring specificity for native target antigens found on the surface of tumour and other target cell types. Antigen recognition by CARs is neither restricted by nor dependent upon human leukocyte antigen antigen expression,favouring widespread use of this technology across transplantation barriers. Signalling is delivered by a designer endodomain that provides a tailored and target-dependent activation signal to polyclonal circulating T-cells. Recent clinical data emphasise the enormous promise of this emerging immunotherapeutic strategy for B-cell malignancy,notably acute lymphoblastic leukaemia. In that context,CARs are generally targeted against the ubiquitous B-cell antigen,CD19. However,CAR T-cell immunotherapy is limited by potential for severe on-target toxicity,notably due to cytokine release syndrome. Furthermore,efficacy in the context of solid tumours remains unproven,owing in part to lack of availability of safe tumour-specific targets,inadequate CAR T-cell homing and hostility of the tumour microenvironment to immune effector deployment. Manufacture and commercial development of this strategy also impose new challenges not encountered with more traditional drug products. Finally,there is increasing interest in the application of this technology to the treatment of non-malignant disease states,such as autoimmunity,chronic infection and in the suppression of allograft rejection. Here,we consider the background and direction of travel of this emerging and highly promising treatment for malignant and other disease types. | May CI van Schalkwyk John Maher | 2015 | World Journal of Immunology2015，5，3： | 0 |
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