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| 1 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 2 | Incidence of radiation pneumonitis after thoracic irradiation: Dose volume correlates 显示文摘 | John MS Robert CM Debra HB | 2007 | Int J Radiat Oncol Biol Phys2007，67，： | 1 |
| 3 | Pulse pressure in normotensive: A marker of cardiovasvular disease显示文摘 | NIKON A JOHN P LEKAKIS CM | 2001 | Am J Hypertens2001，14，： | 1 |
| 4 | Pulse pressure in normotensive:A marker of cardiovascular disease显示文摘 | Lekakis CM Nikos A John P | 2001 | Am J Hypertens2001，14，： | 1 |
| 5 | An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5,Elf-1,HMG-I(Y) and a GATA family protein显示文摘 | John S Robbins CM Ceonard WJ | 1996 | EMBO J1996，15，20： | 1 |
| 6 | Superior efficacy of dendritic cell-tumor fusion vaccine compared with tumor lysate-pulsed dendritic cell vaccine in colon cancer显示文摘 | John Y Kao Zhang M Chen CM | 2005 | Immunol Lett2005，101，： | 1 |
| 7 | 显示文摘 | | 1996 | J Clin Endocrinol Metab1996，81，6： | 1 |
| 8 | Minimization of region- scalable fitting energy for image segmentation 显示文摘 | Li CM Kao CY John CG | 2008 | IEEE Transactions on Image Processing2008，17，10： | 1 |
| 9 | Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis显示文摘 | de Jongh CM John SM Bruynzeel DP | | 0，，： | 1 |
| 10 | Multinational, ob- servational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation:a multicenter observational study显示文摘 | Frank B John CM Richard PD | 2011 | Critical Care2011，15，2： | 1 |
| 11 | Influence of cardiac pacing mode on the long-term development of artrial fibrillation显示文摘 | Joshua MF Adrian HS John CM | 1989 | AmJ Cardiol1989，64，： | 1 |
| 12 | Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management 显示文摘 | John CM Henry NG Pierre A | 2011 | Eur Heart J2011，32，11： | 1 |
| 13 | Postsurgical rehabilitation guide- lines for the orthopedic clinician 显示文摘 | Jeme CM Janet BC John TC | 2009 | Am J Phys Med Rehabi2009，10，： | 1 |
| 14 | Tubulin-dependent biochemical assay for the antineoplastic agent taxol and applications to measurements of the drug in the serum显示文摘 | Hamel E Lin CM Johns DG | 1982 | Cancer Treat Rep1982，66，6： | 1 |
| 15 | Incidence of radiation pneumonitis af- ter thoracic irradiation : dose volume correlates 显示文摘 | John MS Robert CM Debra HB | 2007 | Tnt J Radiat Oncol Biol Phys2007，，： | 1 |
| 16 | Reduced proliferative capacity of hematopoietic stem cells deficient in HOXB3 and HOXB4 显示文摘 | John Mar Bjornsson Larsson N Ann CM | 2003 | Mol Cell Biol2003，23，11： | 1 |
| 17 | Neural system of second language reading are shaped by native language显示文摘 | TAN LIHAI SPINKS JOHN A FENG CM | 2003 | Human Brain Mapp2003，18，3： | 1 |
| 18 | Tissue Doppler echocardiography evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction显示文摘 | Yu CM Chau E John E | 2002 | Circulation2002，105，4： | 1 |
| 19 | Tissue Doppler echocardiography evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure 显示文摘 | Yu CM Chau E John E | 2002 | Circulation2002，105，4： | 1 |
| 20 | Synthetic biodegradable polymers as medical devices显示文摘 | John CM Arthur JT | 1998 | Medical and Biomaterials Magazine1998，134，2： | 1 |
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