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| 1 | 近百年中国气温变化中的不确定性估计显示文摘利用均一化的中国近百年气温观测数据,结合英国East Anglia大学气候研究中心(CRU)的CRUTEM3气温数据集中中国周边国家长序列资料对20世纪前50年资料进行了补充,研制了中国及周边地区近百年逐月5°×5°气温网格数据集,并综合系统考虑了该气温数据集中存在的3类误差(台站误差、抽样误差和偏差误差)导致的不确定性水平,重新构建了近百年全国气温变化序列,并给出了各种不确定性水平,得出了近百年中国气温变化的最新估计.基于上述数据集系统性地对中国近100年地表气温变化趋势进行了重新估计.结果显示:1900~2006年中国气温变化速度为(0.09±0.017)℃/10a;冬季最大,为(0.14±0.021)℃/10a;夏季最小为(0.04±0.017)℃/10a;春季为(0.11±0.021)℃/10a;秋季为(0.07±0.017)℃/10a.近50年(1954~2006年)气温增暖趋势约为(0.26±0.032)℃/10a,近30年(1979~2006年)增暖趋势为(0.45±0.13)℃/10a,气温增暖速率呈明显加剧趋势,值得引起注意.从地理分布上来看,东北、西北和华北地区的增暖幅度最为明显,而西南、华南地区增暖幅度最小,这种变化在近100,50和30年具有较好的一致性. | 李庆祥 董文杰 李伟 高小蓉 JONES Phil KENNEDY John PARKER David | 2010 | 科学通报2010，55，16： | 82 |
| 2 | 藏北高原地壳及上地幔导电性结构——超宽频带大地电磁测深研究结果显示文摘为了研究西藏中、北部壳、幔导电性结构,讨论高原中、北部岩石圈热状态,1998年和1999年(INDEPTH(Ⅲ)-MT)在西藏中、北部完成了德庆—龙尾错(500线)和那曲—格尔木(600线)超宽频带大地电磁深探测剖面的研究.研究结果表明,西藏中、北部以昆仑山断裂为界,其南北壳、幔电性结构有很大差异.昆仑山断裂以北地壳和上地幔为高阻区.而昆仑山以南,地壳和上地幔的导电性有明显的分层结构:地壳上部以不连续的高阻体为主,夹有局部低阻异常体,沿南北方向上地壳的电性结构复杂,具有不连续、分块的特点;但中、下地壳为大范围的高导异常区,区内发育有大规模、不相连续、产状各异的高导体,其电阻率均小于4Ωm;在班公—怒江和金沙江缝合带之下,壳内高导体都具有向上地幔延伸的趋势,存在连通壳、幔的低阻通道.根据西藏高原中、北部壳、幔电性结构的研究推断:如同藏南一样,这里也普遍存在部分熔融体和热流体,它们的成因主要与班公—怒江和金沙江缝合带的壳-幔热交换、热活动有关,这是两期形成的壳-幔热交换通道.其中,班公—怒江缝合带的壳-幔热交换通道形成时间比金沙江缝合带早.因此,研究区壳、幔的热活动是从南边和西边开始,向北、向东扩展,导致现今西藏中、北部地壳和上地幔的热流分布由西向东、由南向北增大. | 魏文博 金胜 叶高峰 邓明 谭捍东 Martyn Unsworth Alan G. Jones John Booker Shenghui Li | 2006 | 地球物理学报2006，49，4： | 71 |
| 3 | 西藏高原南部雅鲁藏布江缝合带地区地壳电性结构研究显示文摘为了探测西藏高原南部雅鲁藏布江缝合带地区地壳浅部和深部构造沿东西和南北方向的变化特征 ,在雅鲁藏布江缝合带地区布设了三条南北向剖面 (错那—墨竹工卡、亚东—雪古拉、吉隆—措勤 ) ,采用超宽频带大地电磁测深方法进行了地壳、上地幔电性结构探测研究 ,发现该区主要电性结构特征为 :1.雅鲁藏布江缝合带附近表层发育大规模的高阻体 ,岩体延伸最深达 30km以上 ,是冈底斯花岗岩体的反映 .2 .雅鲁藏布江缝合带的南部有小规模的良导体 ,在其下方和北侧发育有大规模良导体 .3.沿剖面从南往北壳内普遍发育良导体 ,各良导体主体间是不连续的 ,规模逐渐增大 ,总体北倾 ,在缝合带附近产状较陡 .4 .在雅鲁藏布江缝合带附近良导体由西往东规模逐渐增大 ,导电性逐渐变好 ,相对雅鲁藏布江在剖面上的位置逐渐南移 .这些重要的电性特征可能是印度板块向北俯冲所形成的 。 | 谭捍东 魏文博 Martyn Unsworth 邓明 金胜 John Booker Alan Jones | 2004 | 地球物理学报2004，47，4： | 42 |
| 4 | 西藏高原中、北部断裂构造特征:INDEPTH(Ⅲ)-MT观测提供的依据显示文摘根据1998年和1999年INDEPTH(Ⅲ)MT在西藏中、北部所完成的德庆-龙尾错(500线)和那曲-格尔木(600线)超宽频带大地电磁深探测剖面数据研究西藏高原中北部断裂构造特征,有助于推进印度板块与亚洲板块碰撞、俯冲构造模式的研究.研究结果表明,区内发育有F1~F10一系列深断裂.其中,F2向北倾斜是早期的主断裂,F1则是后期主逆冲断裂,它们共同构成空间结构复杂的嘉黎深断裂带.班公-怒江缝合带的主断裂系由略微向南陡倾的F3、F4和F5三组超壳深断裂构成;由于受后期构造运动强烈的改造,缝合带内发育多条延深不大的上地壳断层.唐古拉断裂带由F6、F7两组主断裂和一系列次级断裂构成;主断裂产状上陡、下缓,总体向南倾斜,向下延深达下地壳.而金沙江缝合带是由F8(金沙江断裂)和F9(可可西里断裂),以及它们之间存在的一系列上地壳次级断层共同组成的,是一组很宽的地块碰撞缝合带.F10即昆中断裂是产状陡立的超壳深断裂,是昆仑山断裂带的主体构造,它构成松潘-甘孜-可可西里地块的北部边界.从剖面电性结构特征分析,昆中断裂以南属于西藏高原主体;而以北地区是否还归属西藏高原?这有待更深入的讨论.值得特别关注的事实是,研究区内2组缝合带之下都存在向上地幔延伸的壳内高导体,它们可能反映区内壳幔热交换过程的痕迹. | 魏文博 金胜 叶高峰 邓明 谭捍东 Martyn Unsworth John Booker Alan G. Jones LI Sheng-hui | 2006 | 地球科学(中国地质大学学报)2006，31，2： | 19 |
| 5 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 6 | In Vivo Phosphorylation Site Mapping and Functional Characterization of Arabidopsis Phototropin 1显示文摘Phototropins (phot1 和 phot2 ) 是控制优化植物的光合的效率的回答的一个范围的蓝光的受体 kinases。察觉到的光被二个黄素绑定主题调停,作为 LOV1 和 LOV2 知道,在蛋白质的 N 终端区域以内定位了。经由 LOV2 的 Photoexcitation 导致 C 终端 kinase 领域并且因而的激活受体 autophosphorylation。然而,为 Arabidopsis phototropins 的 in-vivo phosphorylation 地点的知识在阐明正在缺乏并且阻碍了进步受体 phosphorylation 的功能的意义。我们从 Arabidopsis 净化了 phot1 并且由液体层析双人脚踏车团 spectrometry 识别了受体 phosphorylation 的 in-vivo 地点。导出 Arabidopsis 的 phot1 作为色基绑黄素 mononucleotide 并且是在 LOV2 (Ser58, Ser85, Ser350,和 Ser410 ) 在上游的定位的四个主要地点的 phosphorylated。不过,结构功能分析显示 phot1 的生物活动能被归因于包括蛋白质的 LOV2-kinase 区域的一个模块化的单位。因此,包括这里识别的受体 phosphorylation 的地点, LOV2 在上游的肽区域不看起来为受体发信号重要。由对比,这些区域可能为最大化是必要的有气孔的性能和 phot1 的可能导致光的本地化。 | Stuart Sullivan Catriona E. Thomson Douglas J. Lamont Matthew A. Jones John M. Christie | 2008 | Molecular Plant2008，1，1： | 11 |
| 7 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 8 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 9 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 10 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 11 | Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia显示文摘Characterising the mechanisms of cell death following focal cerebral ischaemia has been hampered by a lack of an in vitro assay emulating both the apoptotic and necrotic features observed in vivo. The present study systematically characterised oxygen-glucose-deprivation (OGD) in primary rat cortical neurones to establish a reproducible model with components of both cell-death endpoints. OGD induced a time-dependent reduction in cell viability, with 80% cell death occurring 24 h after 3 h exposure to 0% O2 and 0.5 mM glucose. Indicative of a necrotic component to OGDinduced cell death, N-methyl-D-aspartate (NMDA) receptor inhibition with MK-801 attenuated neuronal loss by 60%.The lack of protection by the caspase inhibitors DEVD-CHO and z-VAD-fmk suggested that under these conditions neurones did not die by an apoptotic mechanism. Moderating the severity of the insult by decreasing OGD exposure to 60 min did not reduce the amount of necrosis, but did induce a small degree of apoptosis (a slight reduction in cell death was observed in the presence of 10 μtM DEVD-CHO). In separate experiments purported to enhance the apoptotic component, cells were gradually deprived of O2, exposed to 4% O2 (as opposed to 0%) during the OGD period, or maintained in serum-containing media throughout. While NMDA receptor antagonism significantly reduced cortical cell death under all conditions, a caspase-inhibitor sensitive component of cell death was not uncovered. These studies suggest that OGD of cultured cortical cells models the excitotoxic, but not the apoptotic component of cell death observed in vivo. | Paul Alexander JONES Gillian Ruth MAY Joyce Ann MCLUCKIE Akinori IWASHITA John SHARKEY | 2004 | Cell Research2004，14，3： | 3 |
| 12 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 13 | 作为医学人文教育核心的历史学显示文摘尝试从不同的角度讨论史学对于医学核心能力在知识、论证和操作上所发挥的作用。史学对于了解疾病的成因(如非还原论机制需要计算疾病长期以来的变化量)、疗效(如为什么医生认为他们的治疗方案有效,还有就是他们在不同时期的评估方式的变化)有核心贡献。同时有助于了解医学知识和实际操作在不同的社会、经济和政治背景中的偶然性。这些都是医生作为诊断者和治疗者需要知道的。因此史学恰恰能被纳入医学教育中最为盛行的核心技能的培养。 | 方芗(译) | 2018 | 广西民族大学学报(哲学社会科学版)2018，40，2： | 3 |
| 14 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012，，5： | 2 |
| 15 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 16 | Recommended standards for reports dealing with lower extremity ischemia: Revised version显示文摘 | Robert B. Rutherford J.Dennis Baker Calvin Ernst K.Wayne Johnston John M. Porter Sam Ahn Darrell N. Jones | 1997 | Journal of Vascular Surgery1997，，3： | 2 |
| 17 | Inflammatory bowel disease and pregnancy: Lack of knowledge is associated with negative views显示文摘 | Christian P. Selinger Jayne Eaden Warwick Selby D. Brian Jones Peter Katelaris Grace Chapman Charles McDondald John McLaughlin Rupert W.L. Leong Simon Lal | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 18 | Financial liberalization and banking crises in emerging economies显示文摘 | Betty C. Daniel John Bailey Jones | 2006 | Journal of International Economics2006，，1： | 2 |
| 19 | The Potential Use of the South African River Crab, Potamonautes warreni, as a Bioindicator Species for Heavy Metal Contamination显示文摘 | P.-Manuela M. Schuwerack John W. Lewis Peter Jones | 2001 | Ecotoxicology2001，，3： | 2 |
| 20 | Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization显示文摘 | Alexander N. Kapustin John D. Davies Joanne L. Reynolds Rosamund McNair Gregory T. Jones Anissa Sidibe Leon J. Schurgers Jeremy N. Skepper Diane Proudfoot Manuel Mayr Catherine M. Shanahan | 2011 | Circulation Research2011，，1： | 2 |
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