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66篇 您的检索式：作者名="John mk"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Pterygia pathogenesis 显示文摘	Dushku N John MK Schuhz GS	2001	Arch Ophthalmol2001，119，：	1
3	Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John MK Schultz GS	2001	Arch Ophthalrnol2001，119，5：	1
4	Pterygia pathogesis:corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John mk Schuhz GS	2001	Arch Ophthalmol2001，119，5：	1
5	Functional and clinical aspects of the myelomonocyte protein calprotectin 显示文摘	John B Fagerhol MK Lyberg T	1997	Mo Pathol1997，50，2：	1
6	Pterygia pathogenesis:corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John MK Schultz GS Reid TW	2001	Arch Ophthalmol2001，119，5：	1
7	Functional and clinical aspects of the myelomonocyte protein calprotectin显示文摘	Johne B Fagerhol MK Lyberg T	1997	Mol Path1997，50，：	1
8	Polymorphonuclear leudocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke显示文摘	Patrick M kochanek Mk John M	1992	Stroke1992，23，：	1
9	Functional and clinical aspects of the myelomonocyte protein calprotectin 显示文摘	Johne B Fagerhol MK Lyberg T	1997	Mol Pathol1997，50，3：	1
10	Pterygia pathogenesis:corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John MK Schultz GS Reid TW	2001	Arch Ophthalmol2001，119，5：	1
11	Polymorphonuclear Leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke显示文摘	Patrick M Kochanek MK John M	1992	Stroke1992，23，：	1
12	Intrafamilial transmission of HIV-1 infection from individuals with unrecognized HIV-1 infection显示文摘	Martyn AF Belinda LH John MK	2003	AIDS2003，17，：	1
13	Increased sympathetic activity present in early hypertensive Pregnancy is not lowered by plasma volume expansion显示文摘	Wieneke PM Wessel G John MK	2006	Hypertens Pregnancy2006，25，3：	1
14	Electrical remodelling of the left and right atria due to rheumatic mitral stenosis显示文摘	John B Stiles MK Kuklik P	2008	Eur Heart J2008，29，18：	1
15	Pterygia pathogenesis : corneal invasion by matrixmetalloproteinase expressing altered limbal epithelial basal cells 显示文摘	Dushku N John MK Schuhz GS	2001	Arch Ophthalmol2001，119，：	1
16	Pterygia pathogenesis corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John MK Schultz GH	2001	Arch Ophthalmol2001，119，11：	1
17	Pterygia pathogenesis corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘	Dushku N John MK Schultz GH	2001	Arch Ophalmol2001，119，11：	1
18	Pterygia pathogenesis:corneal invasion by matrix metalloproteinase expressioning altered limbal epithelial basal cells 显示文摘	Dushku N John MK Schultz GS	2002	Arch Ophthalmol2002，120，2：	1
19	Increased sympathetic activity present in early hypertensive Pregnancy is not lowered by plasma volume expansion 显示文摘	Wieneke PM Wessel G John MK	2006	Hypertens Pregnancy2006，25，3：	1
20	Edible coating effects on postharvest quality of green bell peppers显示文摘	Sirichit John MK	1996	Journal of Food Science1996，61，1：	1

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