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	题名	作者	年代	出处	被引量
1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
2	Nurse educator competence : A study of Norwegian nurse educators' opinions of the importance and application of different nurse educator competence domains 显示文摘	Johnson KO Aasgaard HS Wahl AK Salminen L	2002	Journal of Nursing Education2002，41，7：	1
3	Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft显示文摘	FRIEDMAN HS JOHNSON SP DONG Q	1997	Cancer Res1997，57，14：	1
4	Long-term slowing of disability progression in patients receiving continuous glatiramer acetate compared with those withdrawing from therapy:10 year results from an ongoing trial显示文摘	JOHNSON KP PANITCH HS FORD CC	2004	Neurology2004，62，75：	1
5	Quality of longterm survival in young children with medalloblastoma显示文摘	Johnson DL McCabe MA Nicholson HS	1994	J Neursurg1994，80，6：	1
6	Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene:genomic structure,promoter sequence,and chromosomal localization显示文摘	Johnson M Yang HS Johanning G L	1997	Genomics1997，41，3：	1
7	Long-term slowing of disability progression in patients receiving continuous glatiramer acetate compared with those withdrawing from therapy : 10 year resuhe from an ongoing trial显示文摘	Johnson KP Panitch HS Ford CC	2004	Neurology2004，62，5：	1
8	Dynamic adaptation of liver mitochordria to chronic alcohol feeding in mice: biogenesis, remode- ling, and functional alterations 显示文摘	Han D Ybanez MD Johnson HS	2012	J Biol Chem2012，287，42：	1
9	Thiazolidinediones and insulin resistance:peroxisome proliferator-activated receptor γ activation stimulates expression of CAP gene显示文摘	Johnson JH Camp HS	1998	Proc Natl Acad Sci USA1998，95，14：	1
10	Thiazolidinediones and in-sulin resistance peroxisome pmliferator activated receptor gaInma activation stimulates expressin of the CAP gene显示文摘	Ribonv Johnson JH Camp HS el al	1998	Proe Natl Acad Sci USA1998，95，11：	1
11	Susceptibility trends of Haemophilus influenzae and Moraxella catarrhalis against orally administered antimicrobial agents:Five-year report from the SENTRY Antimicrobial Surveillance Program显示文摘	Johnson DM Sader HS Fritsche TR	2003	Diagn Microbiol Infect Dis2003，47，1：	1
12	Gastrointestinal absorption factor (f1) for Th from diet 显示文摘	Johnson JR Reply to Dang HS and Sunta CM	1990	Health Phys1990，58，2：	1
13	Mechanisms underlying mouse TNF-a stimttlated neutrophil derived microparti- de generation显示文摘	Johnson BL 3rd Goetzman HS Prakash PS	2013	Bioehem Biophys Res Commun2013，437，4：	1
14	Comparison of the miotic effects of dapiprazole and dilute pilocarpine in patients with the pigment dispersion syndrome显示文摘	Haynes WL Thompson HS Johnson AT	1995	J Glaucoma1995，4，：	1
15	Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines显示文摘	Friedman HS Johnson SP Colvin OH	2002	Cancer Treat Res2002，112，：	1
16	T reatment of cardiogenic shock in my yocardial infaction by intraaortic ballon counterpulsation and surgery 显示文摘	Johnson SA Scanlon PJ Loeb HS	1997	Am JM ed1997，62，：	1
17	Thiazolidinediones and insulin resistance:peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene 显示文摘	Ribon V Johnson JH Camp HS	1998	Proc Natl Acad Sci USA1998，95，14：	1
18	Mechanisms underlying rrouse TNF -α stimulated neutrophil derived mieroparti- de generation 显示文摘	Johnson BL 3rd Goetzman HS Prakash PS	2013	Biochem Biophys Res Commun2013，437，4：	1
19	Long-term Mowing of disability progression in patients receiving continuous glafiramer acetate compared with those withdrawing from therapy: 10 year results from an ongoing trial显示文摘	Johnson KP Panitch HS Ford CC	2004	Neurology2004，625，：	1
20	Leaf and plant water use efficiency of C4 species grown at glacial to elevated CO2 concentrations 显示文摘	Polley HW Johnson HB Mayeux HS	1996	Int J Plant Sci1996，157，：	1

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