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| 1 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 2 | 西双版纳热带森林挥发性有机物的观测研究显示文摘2002年7月中旬利用异戊二烯通量测定系统对云南西双版纳热带森林异戊二烯的排放通量进行了连续测量,同时对光合有效辐射(PAR)、气温、湿度、风等参数进行了观测.结果表明,热带地区人工橡胶林区域湿季异戊二烯的排放有明显的日变化规律,中午前后为一天中的最大值,异戊二烯排放通量的日平均值在0.85~0.24mgC/(m2(h)之间.对小时值和日平均值而言,异戊二烯的排放与PAR和气温的变化规律比较一致,但它对PAR比对气温更加敏感.不同的天气状况对异戊二烯的排放有非常明显的影响.橡胶林是一个单萜烯排放者,其单萜烯的排放速率明显依赖于PAR.橡胶林和热带雨林冠层上空异戊二烯和单萜烯的浓度也有明显的日变化规律,而且橡胶林区域的异戊二烯和单萜烯的浓度均明显高于热带雨林. | 白建辉 Bradly Baker Curtis Johnson 李庆军 王永峰 赵崇奖 Lee Klinger Alex Guenther Jim Greenberg | 2004 | 中国环境科学2004，24，2： | 9 |
| 3 | The Magic of Markets显示文摘The way markets aggregate information and facilitate decentralized planning is almost magical. But paradoxically, the magic continues only because the process is flawed. Therefore, the market is better characterized as being adaptive rather than efficient; and our research should seek to understand, rather than assume, the adaptive process. | Charles M. C. Lee~* Johnson Graduate School of Management, Comell University, Ithaca, NY 14850, USA. | 2003 | 中国会计评论2003，1，0： | 5 |
| 4 | The performance of superhydrophobic and superoleophilic carbon nanotube meshes in water–oil filtration显示文摘 | Chee Huei Lee Nick Johnson Jaroslaw Drelich Yoke Khin Yap | 2010 | Carbon2010，，2： | 2 |
| 5 | CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE. | Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 6 | Outcome After Colectomy for Clostridium Difficile Colitis显示文摘 | Walter E. Longo M.D. John E. Mazuski M.D. Katherine S. Virgo Ph.D. Paul Lee M.D. Anil N. Bahadursingh M.D. Frank E. Johnson M.D | 2004 | Diseases of the Colon & Rectum2004，，10： | 2 |
| 7 | A comparative evaluation of polytetrafluoroethylene, umbilical vein, and saphenous vein bypass grafts for femoral-popliteal above-knee revascularization: A prospective randomized Department of Veterans Affairs cooperative study显示文摘 | Willard C. Johnson Kelvin K. Lee members of the Department of Veteran Affairs COOP Study 141 | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 8 | Comparison of Central and Extended Left Pancreatectomy for Lesions of the Pancreatic Neck显示文摘 | Lee M. Ocuin MD Juan M. Sarmiento MD Charles A. Staley MD John R. Galloway MD Colin D. Johnson MD William C. Wood MD David A. Kooby MD | 2008 | Annals of Surgical Oncology2008，，8： | 2 |
| 9 | Functional substance P receptors on a human astrocytoma cell line (U-373 MG)显示文摘 | LEE C M JOHNSON C G STAUDERMAN K A | 1989 | Brain Res1989，488，12： | 1 |
| 10 | Effects of protease inhibitors and antioxidants on i n vitro survival of porcine primordial germ cells显示文摘 | LEE C K WEAKS R L JOHNSON G A | 2000 | Biol Reprod2000，63，： | 1 |
| 11 | Nrf2, a multi organ protector 显示文摘 | Lee JM Li J Johnson DA | 2005 | FASEB J2005，19，9： | 1 |
| 12 | Nrf2,a multi-organ protector?显示文摘 | LEE JM LI J JOHNSON DA | 2005 | FASEB J2005，19，9： | 1 |
| 13 | Development of the as-cast microstructure in magnesium?aluminium alloys 显示文摘 | DAHLE K A LEE Z C NAVE M D SCHAFFER P L JOHNSON D H | 2001 | Light Metals2001，，1： | 1 |
| 14 | Effect of spinal cord injury se 显示文摘 | Lee JK Emch GS Johnson CS verity on alterations of the H-reflex 430-440 | 2005 | Exp Neurol2005，196，2： | 1 |
| 15 | Gender differences inbenign essential blepharospasm显示文摘 | Lee MS Johnson M Harrison AR | 2012 | Ophthal Plast Recon- str Surg2012，28，3： | 1 |
| 16 | An important role of Nrf2-ARE pathway in the cellular defense mechanism显示文摘 | Lee J M Johnson J A | 2004 | J Biochem Mol Biol2004，37，13： | 1 |
| 17 | Stress and fold localization in thin e lastic membranes 显示文摘 | Pocivavsek L Dellsy R Kern A Johnson S Lin B Lee KY C Cerda E | 2008 | Science2008，320，： | 1 |
| 18 | Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells显示文摘 | Li J Lee JM Johnson JA | 2002 | J Biol Chem2002，277，1： | 1 |
| 19 | Differences in the corneal biomechanical effects of surface ablation compared with laser in situ keratomileusis using a microkeratome or femtosecond laser显示文摘 | Hamilton DR Johnson RD Lee N | 2008 | J Cataract Refract Surg2008，34，12： | 1 |
| 20 | 查看详情显示文摘 | Chen Z Ren Y Lee E Johnson C.Qin Y.Amine K | | 0，，06： | 1 |
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