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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Control of flexible mobile manipulators:positioning and vibration reduction using an eye-in-hand range camera显示文摘 | Bemt N Jonas N | 1999 | Control Engineering Practice1999，7，6： | 2 |
| 3 | Antiangiogenic activity of endostatin inhibits C6 glioma growth显示文摘 | Peroulis I Jonas N Saleh M | 2002 | Int J Cancer2002，97，6： | 1 |
| 4 | Lactoferrin inhibits human papillomavirus binding and uptake in vitro显示文摘 | Peter Drobni Jonas N' aslund Magnus Evander | 2004 | Antiviral Research2004，64，： | 1 |
| 5 | Manage- ment of tumors arising in the parapharyngeal space 显示文摘 | Ricardo L C Eugene N M Jonas T J | 1990 | Laryngoscope1990，100，6： | 1 |
| 6 | Differentiation potential of adult stem cells显示文摘 | Diana Clarke Jonas Frisén | 2001 | Current Opinion in Genetics & Development2001，，： | 1 |
| 7 | The onset of flow localization in tensile samples containing geometric and metallurgical defects显示文摘 | Jonas J J Christodoulou N G'Sell C | 1978 | Scripta Metallurgica1978，12，： | 1 |
| 8 | Laboratory simulation of seamless tube piercing and rolling using dynamic recrystallization schedules 显示文摘 | L N Pussegoda S Yue J J Jonas | 1996 | Metall Trans1996，21，1： | 1 |
| 9 | Cleavage of cellular DNA by calicheamicinγ1 显示文摘 | Kecke E Jonas N | 2003 | DNA Repair2003，2，： | 1 |
| 10 | Effect of phase composition and hydro- gen level on the deformation behavior of titanium-hydrogen allys 显示文摘 | Senkov 0 N Jonas J J | 1996 | Metallurgical and Materials Transactions A1996，27，： | 1 |
| 11 | Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System显示文摘 | Clas B. Johansson Stefan Momma Diana L. Clarke M?rten Risling Urban Lendahl Jonas Frisén | 1999 | Cell1999，，1： | 1 |
| 12 | Comparison of dyrmnaic recrystallization and conventional controlled rolling schedules by laboratory simulation显示文摘 | Pussegoda L N Jonas J J | 1991 | ISIJ International1991，31，3： | 1 |
| 13 | Mechanisms of pancreatic heta-cell death in type 1 and type 2 diabetes:many differences,few similarities显示文摘 | Chop M Welsh N Jonas JC | | 0，，02： | 1 |
| 14 | Asymmetric hetero-diels-alder reactions catalyzed by chiral (Salen)chromium(Ⅲ) complexes显示文摘 | SCOTT E S JONAS B ERIC N J | 1998 | J Org Chem1998，63，2： | 1 |
| 15 | Use of N-ter-minal pro-B-type natriuretic peptide to detect myocardial ischemia显示文摘 | Staub D Jonas N Zellweger MJ | 2005 | Am J Med2005，118，11： | 1 |
| 16 | Laboratory simulation of seamless tube piercing and rolling using dynamic recrystallization schedules显示文摘 | Pussegoda N Yue S Jonas J J | 1990 | Metallurgical TransactionsA1990，21，1： | 1 |
| 17 | Cardiopulmonary bypass increases permeability of the blood-cerebrospinal fluid barrier显示文摘 | Okamura T Ishibashi N Zurakowski D Jonas RA | 2010 | Ann Thorac Surg2010，89，1： | 1 |
| 18 | The onset of flow localization in tensile samples containing geometric and metallurgical defects显示文摘 | Jonas J J Christodoulou N G' Sell C | 1978 | Seripta Metallurgica1978，12，： | 1 |
| 19 | Wound infiltration with postoperative pain and PONV after breast surgery显示文摘 | ANDERS J JONAS K LENA N | 2003 | Journal of Clinical Anesthesia2003，15，： | 1 |
| 20 | Effect of Intermediate Cooling on Grain Refinement and Precipitation During Rolling of Seamless Tubes显示文摘 | Pussegoda L N Yue S Jonas J J | 1991 | Materials Science and Technology1991，7，2： | 1 |
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