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| 1 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Dermatofibrosarcoma protuberans: from translocation to targeted therapy显示文摘Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COL1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABL and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management. | Jonathan Noujaim Khin Thway Cyril Fisher Robin L.Jones | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 5 | High-Density Lipoprotein and Atherosclerosis Regression: Evidence From Preclinical and Clinical Studies显示文摘 | Jonathan E. Feig Bernd Hewing Jonathan D. Smith Stanley L. Hazen Edward A. Fisher | 2014 | Circulation Research2014，，1： | 1 |
| 6 | Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans显示文摘 | John P. Forman Jonathan S. Williams Naomi D.L. Fisher | 2010 | Hypertension2010，，5： | 1 |
| 7 | Radiofrequency Catheter Modification of the Sinus Node for 'Inappropriate' Sinus Tachycardia显示文摘 | Randall J. Lee Jonathan M. Kalman Adam P. Fitzpatrick Laurence M. Epstein Westby G. Fisher Jeffrey E. Olgin Michael D. Lesh Melvin M. Scheinman | 1995 | Circulation1995，，10： | 1 |
| 8 | The retirement consumption conundrum: Evidence from a consumption survey显示文摘 | Jonathan D. Fisher David S. Johnson Joseph Marchand Timothy M. Smeeding Barbara Boyle Torrey | 2007 | Economics Letters2007，，3： | 1 |
| 9 | FITC-induced murine pulmonary inflammation: CC10 up-regulation and concurrent Shh expression显示文摘 | Carolyn E. Fisher Sharon A. Ahmad Paul M. Fitch Jonathan R. Lamb Sarah E.M. Howie | 2005 | Cell Biology International2005，，10： | 1 |
| 10 | γδ T cells for cancer immunotherapy显示文摘 | Jonathan PH Fisher Jennifer Heuijerjans Mengyong Yan Kenth Gustafsson John Anderson | 2014 | OncoImmunology2014，，： | 1 |
| 11 | Preferences for Resuscitation and Intubation Among Patients With Do-Not-Resuscitate/Do-Not-Intubate Orders显示文摘 | John E. Jesus Matthew B. Allen Glen E. Michael Michael W. Donnino Shamai A. Grossman Caleb P. Hale Anthony C. Breu Alexander Bracey Jennifer L. O’Connor Jonathan Fisher | 2013 | Mayo Clinic Proceedings2013，，7： | 1 |
| 12 | Activition of AMP kinase enhances sensitivity muscle glucose transport to insulin显示文摘 | JONATHAN S FISHER JIAPING GAO | 2002 | AM J Physiol Endocrinol Metab2002，282，： | 1 |
| 13 | Comparison of different HCV viral load and genotyping assays显示文摘 | Jonathan C Anderson Josephine Simonetti Dennis G Fisher James Williams Yasuhiro Yamamura Nayra Rodriguez Daniel G Sullivan David R Gretch Brian McMahon Kandace J Williams | 2002 | Journal of Clinical Virology2002，，1： | 1 |
| 14 | Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism显示文摘 | Sajesh Parathath Stephanie L. Mick Jonathan E. Feig Victor Joaquin Lisa Grauer David M. Habiel Max Gassmann Lawrence B. Gardner Edward A. Fisher | 2011 | Circulation Research2011，，10： | 1 |
| 15 | Measuring, modeling and mapping ecosystem services in the Eastern Arc Mountains of Tanzania显示文摘 | Fisher Brendan Turner R Kerry Burgess Neil D Swetnam Ruth D Green Jonathan Green Rhys E Kajembe George Kulindwa Kassim Lewis Simon L Marchant Rob Marshall Andrew R Madoffe Seif Munishi PKT Morse-Jones Sian Mwakalila Shadrack Paavola Jouni | 2011 | Progress in Physical Geography2011，，5： | 1 |
| 16 | Mechanisms of photoreceptor death and survival in mammalian retina显示文摘 | Jonathan Stone Juliani Maslim Krisztina Valter-Kocsi Kyle Mervin Felicity Bowers Yi Chu Nigel Barnett Jan Provis Geoff Lewis Steven K Fisher Silvia Bisti Claudia Gargini Luigi Cervetto Saul Merin Jacob Pe’er | 1999 | Progress in Retinal and Eye Research1999，，6： | 1 |
| 17 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 18 | A prospective evaluation of indications for neurological consul- tation in the emergency department显示文摘 | Christopher K Hansen Jonathan Fisher Nina R Joyce | 2015 | International Journal of Emergency Medicine2015，8，1： | 1 |
| 19 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
| 20 | A prospective evaluation of indications for neurological con- sultation in the emergency department显示文摘 | Christopher K Hansen Jonathan Fisher Nina R Joyce | 2015 | International Jour- nal of Emergency Medicine2015，8，1： | 1 |
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