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| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 5 | Characterization of germ cells from pre-pubertal bull calves in prepara- tion forgerm cell transplantation显示文摘 | Murren H Rhonda J D Jonathan R | 2007 | Cell and Tissue Research2007，330，： | 1 |
| 6 | Using simula- tion to inteIpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows显示文摘 | Christopher D H Jonathan N H Martin J G | 2014 | Plos 0ne2014，9，8： | 1 |
| 7 | Shadow Prices, Market Wages, and Labor Supply显示文摘 | Jonathan H Matthew J S | 1999 | Econometrica1999，，4： | 1 |
| 8 | Titanium armor applications in combat vehicles显示文摘 | JONATHAN S MONTGOMERY J S WELLS M G H | 2001 | Journal of Metals2001，53，4： | 1 |
| 9 | Metabolic response of juvenile gray snapper (Lutjanus griseus ) to temperature and salinity: Physiological cost of different environments 显示文摘 | MARK J W AMELIA R J JONATHAN A H | 2005 | Journal of Experimental Marine Biology and Ecology2005，321，2： | 1 |
| 10 | Hydrophobically modified associative polymer solutions:rheology and microstructure in the presence of nonionicsurfactants显示文摘 | ROBERT J E JONATHAN H L RICHARD J S | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 11 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 12 | Adhesion of thin coatings-the VAMAS (TWA 22-2) interlaboratory exercise显示文摘 | GILES A S NIGEL J JONATHAN H | 2005 | Surface and Coatings Technology2005，197，23： | 1 |
| 13 | Ice and water permittivities for mil- limeter and sub-miUimeter remote sensing applications显示文摘 | Jonathan H J Dong L W | 2004 | At- mospheric Science Letters2004，5，7： | 1 |
| 14 | Modeling of chaotic DC/DC converters by iterated nonlinear mappings显示文摘 | David C H Jonathan H B D David J | 1992 | Power Electronics1992，7，1： | 1 |
| 15 | Progressive rise in red cell distribution width is associated with poor outcome after transcatheter aortic valve implantation显示文摘 | Nay Aung Rafal Dworakowski Jonathan Byrne Emma Alcock Ranjit Deshpande Kailasam Rajagopal Beth Brickham Mark J Monaghan Darlington O Okonko Olaf Wendler Philip A MacCarthy Guleed Adan Samer H Ghozlan | 2013 | Heart2013，，： | 1 |
| 16 | Surgical anatomy of the hepatic arteries in 1000 cases显示文摘 | Jonathan R H Gabbay J Ronald W B | 1994 | Annals Surgery1994，220，1： | 1 |
| 17 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 18 | Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex显示文摘 | Huang Ying Wu Zhiping Riwanto Meliana Gao Shengqiang Levison Bruce S Gu Xiaodong Fu Xiaoming Wagner Matthew A Besler Christian Gerstenecker Gary Zhang Renliang Li Xin-Min DiDonato Anthony J Gogonea Valentin Tang W H Wilson Smith Jonathan D | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 19 | Tensile-Reinforcement Effect on Bridge-Approach Settlement 显示文摘 | Jonathan T H Wu | 1993 | Journal of Geotechnical Engineering1993，119，4： | 1 |
| 20 | Class Ⅱ transactivatonmastering the art of major histocompatibility complex expression显示文摘 | Jonathan A H Ting J P | 2000 | Mol Cell Biol2000，20，： | 1 |
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