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| 1 | UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis显示文摘Protein biogenesis at the endoplasmic reticulum(ER)in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation(ERAD).While there has been substantial progress in understanding how ERAD eliminates defective polypeptides generated from erroneous folding,how cells remove nascent chains stalled in the translocon during co-translational protein insertion into the ER is unclear.Here we show that ribosome stalling during protein translocation induces the attachment of UFM1,a ubiquitin-like modifier,to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26(uL24)at the ER.Strikingly,RPL26 UFMylation enables the degradation of stalled nascent chains,but unlike ERAD or previously established cytosolic ribosome-associated quality control(RQC),which uses proteasome to degrade their client proteins,ribosome UFMylation promotes the targeting of a translocation-arrested ER protein to lysosomes for degradation.RPL26 UFMylation is upregulated during erythroid differentiation to cope with increased secretory flow,and compromising UFMylation impairs protein secretion,and ultimately hemoglobin production.We propose that in metazoan,co-translational protein translocation into the ER is safeguarded by a UFMylation-dependent protein quality control mechanism,which when impaired causes anemia in mice and abnormal neuronal development in humans. | Lihui Wang Yue Xu Heather Rogers Layla Saidi Constance Tom Noguchi Honglin Li Jonathan Wilson Yewdell Nicholas Raymond Guydosh Yihong Ye | 2020 | Cell Research2020，30，1： | 5 |
| 2 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 3 | Cardiac Steatosis in Diabetes Mellitus: A 1H-Magnetic Resonance Spectroscopy Study显示文摘 | Jonathan M. McGavock Ildiko Lingvay Ivana Zib Tommy Tillery Naomi Salas Roger Unger Benjamin D. Levine Philip Raskin Ronald G. Victor Lidia S. Szczepaniak | 2007 | Circulation2007，，10： | 1 |
| 4 | Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase显示文摘 | Jonathan T. Butcher Russell A. Norris Stanley Hoffman Corey H. Mjaatvedt Roger R. Markwald | 2006 | Developmental Biology2006，，1： | 1 |
| 5 | Characteristics of milk powders produced by spray freeze drying显示文摘 | Rogers Samuel Wu Winston Duo Saunders Jonathan | 2008 | Drying Technology2008，26，： | 1 |
| 6 | A new approach to reproducibility assessment: clinical evaluation of SpaceLabs Medical oscil lometric blood pressure monitor显示文摘 | Mark Sun Jonathan Tien Roger Jones | 1996 | Biomed lnstrum & Technol1996，30，5： | 1 |
| 7 | Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review显示文摘 | Rachel L. McIntosh Sophie L. Rogers Lyndell Lim Ning Cheung Jie Jin Wang Paul Mitchell Jonathan W. Kowalski Hiep P. Nguyen Tien Yin Wong | 2010 | Ophthalmology2010，，6： | 1 |
| 8 | A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints显示文摘 | Roger M.Harbord MatthiasEgger Jonathan A. C.Sterne | 2006 | Statist Med2006，，20： | 1 |
| 9 | Natural History of Branch Retinal Vein Occlusion: An Evidence-Based Systematic Review显示文摘 | Sophie L. Rogers Rachel L. McIntosh Lyndell Lim Paul Mitchell Ning Cheung Jonathan W. Kowalski Hiep P. Nguyen Jie Jin Wang Tien Yin Wong | 2010 | Ophthalmology2010，，6： | 1 |
| 10 | The symptomatic carotid plaque显示文摘 | Jonathan G Roger M Greenhalgh-Alun H | 2000 | Stroke2000，，31： | 1 |
| 11 | Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs显示文摘 | True L. Rogers Ian B. Gillespie James E. Hitt Kevin L. Fransen Cindy A. Crowl Christopher J. Tucker Gary B. Kupperblatt Joe N. Becker Deb L. Wilson Clifford Todd Charles F. Broomall Jonathan C. Evans Edmund J. Elder | 2004 | Pharmaceutical Research2004，，11： | 1 |
| 12 | A Prospective, Randomized, Controlled Trial of Single-Incision Laparoscopic (SILS) versus Conventional 3-port Laparoscopic Appendectomy for the Treatment of Acute Appendicitis显示文摘 | Jonathan T. Carter Jennifer A. Kaplan Jason N. Nguyen Matthew Y.C. Lin Stanley J. Rogers Hobart W. Harris | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 13 | Using Lesson Study and Authentic Achievement:Model For Teacher Collaboration显示文摘 | Roger A Stewart Jonathan L Brendefur | 2005 | Phi Delta Kappan2005，，5： | 1 |
| 14 | Design of a Roll-Stabilized Mortar Projectile with Reciprocating Canards 显示文摘 | Jonathan Rogers Mark Coste|lo | 2010 | JOUR- NAL OF GUIDANCE CONTROL AND DYNAMICS2010，，4： | 1 |
| 15 | TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling显示文摘 | Céline E. Riera Mark O. Huising Patricia Follett Mathias Leblanc Jonathan Halloran Roger Van Andel Carlos Daniel de Magalhaes Filho Carsten Merkwirth Andrew Dillin | 2014 | Cell2014，，： | 1 |
| 16 | A 10-Gb/s CMOS clock and data recovery circuit with a half-rate binary phase/frequency detector显示文摘 | Jonathan E Rogers John R Long | 2003 | IEEE Journal of Solid-State Circuits2003，38，1： | 1 |
| 17 | Credibility On Management Forecasts 显示文摘 | Rogers Jonathan L Stoeken Phillip C | 2005 | The Accounting Review2005，80，4： | 1 |
| 18 | Insight into the nonlinear absorbance of two related series of two-photon absorbing chromophores 显示文摘 | Joy E Rogers Jonathan E Slagle Daniel G McLean | 2007 | J Phys Chem A2007，111，： | 1 |
| 19 | Nucleic acid - based fluorescent probes in microbial ecology : application of flow cytometry 显示文摘 | Jonathan Porter Roger W Pickup | 2000 | J Microbiol Meth2000，42，： | 1 |
| 20 | The symptomatic carotid plaque显示文摘 | Jonathan G Roger M Greenhalgh-Alun H | 2000 | Stroke2000，31，： | 1 |
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