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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Cellular and Subcellular Patterns of Expression of bFGF and CNTF in the Normal and Light Stressed Adult Rat Retina显示文摘 | Natalie Walsh Krisztina Valter Jonathan Stone | 2001 | Experimental Eye Research2001，，5： | 1 |
| 3 | Systematic Characterization of the Computed Tomography Angiography Spot Sign in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk for Hematoma Expansion: The Spot Sign Score显示文摘 | Josser E. Delgado Almandoz Albert J. Yoo Michael J. Stone Pamela W. Schaefer Joshua N. Goldstein Jonathan Rosand Alexandra Oleinik Michael H. Lev R Gilberto Gonzalez Javier M. Romero | 2009 | Stroke2009，，： | 1 |
| 4 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 5 | Unprotected Left Main Coronary Disease and ST-Segment Elevation Myocardial Infarction显示文摘 | Michael S. Lee Pooya Bokhoor Seung-Jung Park Young-Hak Kim Gregg W. Stone Imad Sheiban Giuseppe Biondi-Zoccai Dario Sillano Jonathan Tobis David E. Kandzari | 2010 | JACC: Cardiovascular Interventions2010，，： | 1 |
| 6 | The Spot Sign Score in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk of In-Hospital Mortality and Poor Outcome Among Survivors显示文摘 | Josser E. Delgado Almandoz Albert J. Yoo Michael J. Stone Pamela W. Schaefer Alexandra Oleinik H Bart Brouwers Joshua N. Goldstein Jonathan Rosand Michael H. Lev R Gilberto Gonzalez Javier M. Romero | 2010 | Stroke2010，，1： | 1 |
| 7 | Mechanisms of photoreceptor death and survival in mammalian retina显示文摘 | Jonathan Stone Juliani Maslim Krisztina Valter-Kocsi Kyle Mervin Felicity Bowers Yi Chu Nigel Barnett Jan Provis Geoff Lewis Steven K Fisher Silvia Bisti Claudia Gargini Luigi Cervetto Saul Merin Jacob Pe’er | 1999 | Progress in Retinal and Eye Research1999，，6： | 1 |
| 8 | 广西桉树人工林树冠结构与立地指数对其林冠郁闭的影响(英文)显示文摘世界上很多地区基于桉树的商业价值开展了桉树人工林的经营。密度管理在桉树人工林经营管理中往往成为很重要的手段。该研究以不同林龄的桉树人工林为研究对象,在森林郁闭和树木生长竞争期,量化其森林郁闭度和冠层结构。通过对桉树人工林的调查,研究了其林地指数对其林冠郁闭度的影响。结果表明:立地指数对郁闭度影响不大,在好的立地条件下森林郁闭度有轻微的影响。基于树冠投影面积比和树冠直径和胸径的比值研究表明:桉树林在4年生时开始郁闭。对不同林龄的相对间距RS值的研究表明:相对间距值在第4年时表现出快速降低,到21年的时候逐渐变得相对平缓。桉树林在前3年表现出快速的高生长,由于速生,其在密度上没有多大变化。4年生桉树林由于死亡率导致树木个体数量的减少,影响了RS值,导致其逐渐下降。 | 陶玉华 Roger WILLIAMS Carol BROWN 曹书阁 Rachael CRANE Raymond DUVAL Dani FLOWERS Jonathan FRANKO Rachel HEFFLINGER Jonathan JOO Anne MAURO Crista RIEDY Margaret SMYTH Shawn STONE 谭丽凤 | 2014 | Agricultural Science & Technology2014，15，6： | 1 |
| 9 | Molecular expression of acute phase mediators is attenuated by machine preservation in human liver transplantation: Preliminary analysis of effluent, serum, and liver biopsies显示文摘 | Jacob E. Tulipan Jonathan Stone Benjamin Samstein Tomoaki Kato Jean C. Emond Scot D. Henry James V. Guarrera | 2011 | Surgery2011，，2： | 1 |
| 10 | Targeting the body to protect the brain:inducing neuroprotection with remotely-applied near infrared light显示文摘The incidence of intractable age-related neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases and age-related macular degeneration is projected to increase substantially over the coming decades with the ageing of the global population.While the burden of disease associated with other chronic conditions has decreased in | Daniel M.Johnstone John Mitrofanis Jonathan Stone | 2015 | Neural Regeneration Research2015，10，3： | 0 |
| 11 | The code of light:do neurons generate light to communicate and repair?显示文摘A great challenge in neuroscience has been to understand how neurons communicate.The neuroanatomists of the 19th Century could see neurons stretching processes to contact other neurons,but could not see the detail of the contact.Many thought that neurons formed a syncytium,with continuity of membranes from one to the next.Over the ensuing two hundred years or so,we have come to understand that the circuity of the brain is not formed by a syncytium of neurons;rather,individual neurons communicate with each other with a range of biological signals.Neurons are highly active cells,with their activity being electrical and their communication being either chemical,electrical or gaseous. | Cecile Moro Ann Liebert Catherine Hamilton Nicolas Pasqual Glen Jeffery Jonathan Stone John Mitrofanis | 2022 | Neural Regeneration Research2022，17，6： | 0 |
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