|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Concordance between functional magnetic resonance imaging and introperative language mapping显示文摘 | MAXIMILIAN I R JONATHAN D V SYED H | 1999 | Stereotact Funct Neurosurg1999，72，4： | 1 |
| 5 | Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation 显示文摘 | Jonathan G H Ann E V Matthew R W | 2001 | Green Chem2001，3，： | 1 |
| 6 | Early psychological adjustment in breast cancer patients-A prospective study显示文摘 | Chiara N Jonathan V R Timothy C | 2002 | J Psycho Res2002，53，6： | 1 |
| 7 | A 20-kilodalton protein is required for efficient production of the Bacillus thuringiensis subsp,israelensis 27-kilodalton crystal protein in Escherichia coli显示文摘 | ADAMS L F JONATHAN E V WHITELY H R | 1989 | J Bacteriol1989，171，： | 1 |
| 8 | The uses of passive measurement of acoustic emissions from chemical engineering processes显示文摘 | JONATHAN W R BOYD J V | 2001 | Chemical Engineering Science2001，56，： | 1 |
| 9 | Periodically Poled Lithium Niobate Waveguide Sum-frequency Generator for Efficient Single-photon Detection at Communication Wavelengths 显示文摘 | ROUSSEV ROSTISLAV V CARSTEN LANGROCK KURZ JONATHAN R | 2004 | OPTICS LETTERS2004，29，： | 1 |
| 10 | The im- pact of elevated water ammonia and nitrate concentrations on physiology, growth and feed intake of pikepereh ( San- der lucioperca) 显示文摘 | Edward S Jonathan A C R Tiedo V K | 2014 | Aquaculture2014，，： | 1 |
| 11 | Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol显示文摘 | EDMOND A R JONATHAN RL RAY V R | 2001 | Diabetes2001，40，3： | 1 |
| 12 | CD44 is required for two consecutive steps in HGF/c-Met signaling显示文摘 | Véronique O R Chen L F Jonathan P | 2002 | Gene & Development2002，16，23： | 1 |
| 13 | Determination of furosine in honey显示文摘 | JONATHAN C R BLEN G V EDUARDO G H | 2003 | J Liq Chromatogr Relat Technol2003，26，2： | 1 |
| 14 | Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 hours in patients with sepsis显示文摘 | Stephen Trzeciak Jonathan V Mc Coy R Phillip Dellinger | 2008 | Intensive Care Med2008，34，12： | 1 |
| 15 | Software-controlled fault tolerance显示文摘 | George A R Jonathan C Neil V | 2005 | ACM Transactions on Architecture and Code Optimization2005，2，4： | 1 |
| 16 | Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation显示文摘 | JONATHAN G H ANN E V MATTHEW R W | 2001 | Green Chem2001，3，12： | 1 |
| 17 | The uses of passive measurement of acoustic emissions from chemical engineering processes显示文摘 | JONATHAN W R B JULIE V | 2001 | Chemical Engineering Science2001，56，： | 1 |
| 18 | Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imida-zolium cation显示文摘 | Jonathan G H Ann E V Matthew R W | 2001 | Green Chem2001，3，： | 1 |
| 19 | The Impact of Psychological and Human Capiml on Wages 显示文摘 | Goldsmith A H Jonathan R V William D J | 1997 | Economic Inquiry1997，10，34： | 1 |
| 20 | The Impact of Psychological and Human Capimlon Wages 显示文摘 | Goldsmith A H Jonathan R V Wiltiam DJ | 1997 | Economic Inquiry1997，10，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员