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| 1 | Effect of the modulation of leucine zipper tumor suppressor 2 expression on proliferation of various cancer cells functions as a tumor suppressor显示文摘 | Jong MK Ji SS Hyun HC | 2011 | Mol Cell Biochem2011，346，12： | 1 |
| 2 | Drone- darone acts as a selective inhibitor of 3,5,3 '- triio- dothyronine binding to thyroid hormone receptor, al- phal: in vitro and in vivo evidenee 显示文摘 | Van Beeren HC Jong WM Kaptein E | 2003 | Endocrinolo- gy2003，144，2： | 1 |
| 3 | Results of a study on fatigue in breast cancer patients receiving adjuvant chemotherapy:the first four days after treatment are the worst显示文摘 | de Jong N Kester AD Schouten HC | 2007 | Pflege Z2007，60，11： | 1 |
| 4 | Course of fatigue between two cycles of adjuvant chemotherapy in breast cancer patients 显示文摘 | de Jong N Kester AD Schouten HC | 2006 | Cancer Nurs2006，29，6： | 1 |
| 5 | A double-blind, randomised, placebo controlled study on the influence of carbohydrate solution intake during labour显示文摘 | Scheepers HC Thans MC de Jong PA | 2002 | BJOG2002，109，2： | 1 |
| 6 | Optimal dose range of epidural naloxone to reduce nausea in patients receiving epidural morphine 显示文摘 | Eun SK Jaemin L Jong HC | 2004 | Can J Anesth2004，51，10： | 1 |
| 7 | Effect of the modulation of leucine zipper tumor suppressor 2 expression on proliferation of various cancer cells functions as a tumor suppressor 显示文摘 | Jong MK Ji SS Hyun HC | 2011 | Mol Cell Biochem2011，346，12： | 1 |
| 8 | Course of fatigue between two cycles of adjuvant chemotherapy in breast cancer patients显示文摘 | de Jong N Kester AD Schouten HC | 2006 | Cancer Nursing2006，29，6： | 1 |
| 9 | Prevalence and course of fatigue in breast cancer patients receiving adjuvant chemotherapy 显示文摘 | de Jong N Candel MJ Schouten HC | 2004 | Ann 0ncol2004，15，6： | 1 |
| 10 | Dronedarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alphal:in vitro and in vivo evidence显示文摘 | Van Beeren HC Jong WM Kaptein E | 2003 | Endocrinology2003，144，2： | 1 |
| 11 | Value of the model for end-stage liver disease for predicting survival in hepatocellular carcinoma patients treated with transarterial chemoembolization 显示文摘 | JEONG HK JI HK JONG HC | 2009 | Scand J Gastroentero2009，44，： | 1 |
| 12 | A dou- ble-blind,randomised, placebo controlled study on the in- fluence of carbohydrate solution intake during labour 显示文摘 | SCHEEPERS HC THANS MC DE JONG PA | 2002 | B JOG2002，109，2： | 1 |
| 13 | The effects of oral carbohydrate administration on fetal acid base balance显示文摘 | SCHEEPERS HC THANS MC DE JONG PA | 2002 | J Perinat Med2002，30，5： | 1 |
| 14 | Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans显示文摘Background and Aim:Animal studies indicated that systemic ophthalmic acid(OPH)is a biomarker for hepatic glutathione(GSH)homeostasis,an important determinant of liver function.We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol(APAP)challenges during pylorus-preserving pancreaticoduodenectomy(PPPD)or partial hepatectomy(PH).Methods:Nineteen patients undergoing PPPD(n=7,control group)or PH(n=12)were included.APAP(1000 mg)was administered intravenously before resection(first challenge),and six and twelve hours later,with sequential blood sampling during this period.Arterial,hepatic and portal venous blood samples and liver biopsies were taken on three occasions during the first APAP challenge.Plasma and hepatic OPH and GSH levels were quantified,and venous-arterial differences were calculated to study hepatic release.Results:Systemic GSH levels decreased during the course of the APAP challenge in both surgical groups,without notable change in OPH levels.Hepatic GSH and OPH content was not affected within^3 hours after administration of the first APAP dose in patients undergoing PPPD or PH.In this period,net release of OPH by the liver was observed only in patients undergoing PPPD.Conclusions:The drop in circulating GSH levels following APAP administrations,did not result in an increase in plasma OPH in both patients with an intact liver and in those undergoing liver resection.Hepatic content of GSH and OPH was not affected during the first APAP dose.It is uncertain whether hepatic GSH homeostasis was sufficiently challenged in the present study.Relevance for patients:In the present study,plasma OPH seemed not useful as a marker for GSH depletion because APAP administration during liver surgery did not lead to(immediate)GSH depletion or increased OPH levels.Based on stable levels of hepatic GSH,OPH and thiyl radicals during surgery,standard APAP administration seems to be safe in a postoperative care program with regards to GSH homeostasis in this specific population.However,no general statements can be made on the basis of the current experiment,since GSH homeostasis and susceptibility to xenobiotic toxicity are influenced by several metabolic and genetic factors. | Kim MC van Mierlo Simon AWG Dello Mechteld C de Jong Hans MH van Eijk Theo M de Kok Jacob J Briedé Frank G Schaap Steven WM Olde Damink Cornelius HC Dejong | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
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