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| 1 | Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery显示文摘为指向的同时的肿瘤的 Subcellular 细胞器特定的 nanoparticles,成像,和药交货具有对癌症治疗的庞大的兴趣。此处,我们报导一根选择指向线粒体的探针 1,它被与 cyanostilbene 和长烷基链一半合并 triphenyl 磷化氢综合。探查 1 被发现经由导致聚集的排放(AIE ) 显示荧光。低分子重量的基于 cyanostilbene 的探查有或没有 anticancer 药, 1 与 ca 形成了狭窄的同类的 nanorod。有 ca 的长度或 nanoparticles 的 110 nm。在水的媒介的 20 nm 直径。自我装配的 cyanostilbene nanoparticles (N1 ) 有选择地在癌症房间的线粒体积累了并且射出荧光。N1 也能交付 anticancer 药, doxorubicin (纪录影片) ,到有高效率的线粒体。更重要地, N1 在正常房间上为癌症房间展出了高度选择的 cytotoxicity。到生物系统的这自我装配的 nanoparticle 的大潜在的应用程序源于它在线粒体聚集的能力。这聚集在癌症房间在 mitochondrial 膜潜力在细胞内部的反应的氧种类并且到减少的产生导致了重要增加。而且,在老鼠的肿瘤织物举起实验建议自我装配的 N1 有能力使内在化并且有效地交付 anticancer 药进肿瘤纸巾。而且, N1 和包含 N1 的 doxorubicin (N1 纪录影片) 有效地在 vivo 在一个异种皮移植模型压制了肿瘤生长。一起拿,我们的调查结果显示 N1 的应用程序为潜在的指导图象的治疗以及一个地点特定的交货系统作为指向探查,药交货平台,和化学疗法的代理人的 mitochondrial 提供唯一的策略给癌症房间。 | Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae Jong Hwa Jung | 2018 | Nano Research2018，11，2： | 4 |
| 2 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://magicproject.org/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 3 | Upregulation of tissue inhibitor of metalloproteinases TIMP-2 promotes matrix metalloproteinase MMP-2 activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，： | 1 |
| 4 | No evidence found thatchildhood onset of psoriasis influences disease severity,future bodymass index or type of treatments used 显示文摘 | de Jager ME de Jong EM Meeuwis KA | 2010 | J Eur Acad Dermatol Vene-reol2010，24，11： | 1 |
| 5 | Changed patterns of cerebral activation related to clinically normal hand movement in cervical dystonia 显示文摘 | de Vries PM Johnson KA de Jong BM | 2008 | Clin Neurol Neurosurg2008，1110，2： | 1 |
| 6 | Upregulation of tissue inhibitor of metalloproteinaseS(TIMP2) promotes matrixmetalloproteinase(MMP2) activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 7 | Upregulation of tissueinhibitor of metalloproteinases(TIMP)-2 promotes matrixmetalloproteinese(MMP)-2 activation and cell invasion in ahuman glioblastoma cell line 显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 8 | Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase ( MMP)-2 activation and cell invasion in a human glioblastoma cell line 显示文摘 | Lu KV Jong KA Rajasekaran AK Cloughesy TF | 2004 | Lab Invest2004，84，1： | 1 |
| 9 | Upregulation Of tissue inhibitor of metalloproteinases(MMP-2)activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 10 | Differential dnduction of glioblastoma migration and growth by two forms of pleiotrophin 显示文摘 | Lu KV Jong KA Kim GY | 2005 | J Biological Chemistry2005，280，26： | 1 |
| 11 | Upregulatio of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix mefalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line 显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 12 | Human infection with highly pathogenic HSN1 influenza virus 显示文摘 | Gambotto A Barratt-Boyes SM de Jong MD Neumann G Kawao- ka Y | 2008 | Lancet2008，371，9622： | 1 |
| 13 | Differential induction of glioblastoma migration and growth by two forms of pleiotrophin显示文摘 | Lu KV Jong KA Kim GY | | 0，，： | 1 |
| 14 | The human lactase persistence as- sociated SNP-13910 * T enables in vivo functional persistence of lac- tase promoter-reporter transgene expression 显示文摘 | Lin F Jong KA Dariusz W | 2012 | Hum Genet2012，131，7： | 1 |
| 15 | Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran A K | 2004 | Lab Invest2004，84，1： | 1 |
| 16 | Upregulation of tissue inhibittor of metalloproteinases ( MIMP-2 ) promotes matrix metalloproteinase (MMP-2) activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2009 | Lab Invest2009，84，1： | 1 |
| 17 | Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 18 | Emotion-on-a-chip (EOC):Evolution of biochip technology to measure human emotion using body fluids显示文摘 | Lee JH Hwang Y Cheon KA Jong HI | | 0，，06： | 1 |
| 19 | Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP) -2 activation and cell invasion in a human glioblastoma cell line显示文摘 | Lu KV Jong KA Rajasekaran AK | 2004 | Lab Invest2004，84，1： | 1 |
| 20 | An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines显示文摘 | Jong EC Kaplan KM Eves KA | 2002 | J Travel Med2002，9，2： | 1 |
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