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| 1 | Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer显示文摘AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy(NACRT) for resectability of locally advanced gastric cancer(LAGC).METHODS:Between November 2007 and January 2014,29 patients with LAGC(clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT followed by D2 gastrectomy were included in this study.Resectability was evaluated with radiologic and endoscopic exams before and after NACRT.Using threedimensional conformal radiotherapy,patients received 45 Gy,with a daily dose of 1.8 Gy.The entire tumor extent and the regional metastatic lymph nodes were included in the gross tumor volume.Patients presenting with a resectable tumor after NACRT received a total or subtotal gastrectomy with D2 dissection.The pathologic tumor response was evaluated using Japanese Gastric Cancer Association histologic evaluation criteria.Postoperative morbidity was evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4.0.Overall survival(OS) and progression-free survival(PFS) rates were estimated using a Kaplan-Meier analysis and compared using the log-rank test.RESULTS:All patients were assessed as unresectable cases.Twenty-four patients(24/29; 82.8%) showed LAGC on positron emission tomography-computed tomography(CT) and contrast-enhanced CT,whereas four patients(4/29; 13.8%) with vague invasion orabutment to an adjacent organ underwent diagnostic laparoscopy.One patient(1/29; 3.4%),initially assessed as a resectable case,underwent an 'open and closure' after the tumor was found to be unresectable.Abutment to an adjacent organ(34.5%) was the most common reason for NACRT.The clinical response rate one month after NACRT was 44.8%.After NACRT,69%(20/29) of patients had a resectable tumor.Of the 20 patients with a resectable tumor,18 patients(62.1%) underwent a D2 gastrectomy.The R0 resection rate was 94.4% and two patients(2/18; 11.1%) showed a complete response.The median follow-up duration was 13.5 mo.The one-year OS and PFS rates were 72.4 and 48.9%,respectively.The one-year OS,PFS,local failure-free survival,and distant metastasis-free survival were higher in patients with a resectable tumor after NACRT(P < 0.001,P < 0.001,P < 0.001,and P =0.078,respectively).No grade 3-4 late treatment-related toxicities or postoperative mortalities were observed.CONCLUSION:NACRT with D2 gastrectomy showed a high rate of R0 resection and promising local control,which may increase the R0 resection opportunity resulting in survival benefit. | Mi Sun Kim Joon Seok Lim Woo Jin Hyung Yong Chan Lee Sun Young Rha Ki Chang Keum Woong Sub Koom | 2015 | World Journal of Gastroenterology2015，21，9： | 15 |
| 2 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology:A meta-analysis显示文摘AIM: To evaluate the efficacy and safety of endoscopicsubmucosal dissection(ESD) for early gastric cancer(EGC) with undifferentiated-type histology.METHODS: A systematic literature review was conducted using the core databases. Complete resection,curative resection, en bloc resection, recurrence and adverse event rate were extracted and analyzed. A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. Publication bias was evaluated using a funnel plot, the trim and fill method, Egger's test,and a rank correlation test.RESULTS: Fourteen retrospective studies between2009 and 2014 were identified(972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as92.1%(95%CI: 87.4%-95.2%) and 77.5%(95%CI:69.3%-84%), respectively. The total curative resection rate was 61.4%(95%CI: 44.5%-75.9%). The overall recurrence rate was 7.6%(95%CI: 3.4%-16%).Limited to histologically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were91.2% and 85.6%, respectively. The curative resection rate was 79.8%.CONCLUSION: In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiatedtype histology. Long-term studies are needed to confirm these therapeutic outcomes. | Chang Seok Bang Gwang Ho Baik In Soo Shin Jing Bong Kim Ki Tae Suk Jai Hoon Yoon Yeon Soo Kim Dong Joon Kim Woon Geon Shin Kyung Ho Kim Hak Yang Kim Hyun Lim Ho Seok Kang Jong Hyeok Kim Jin Bae Kim Sung Won Jung Sea Hyub Kae Hyun Joo Jang Min Ho Choi | 2015 | World Journal of Gastroenterology2015，21，19： | 14 |
| 3 | Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior显示文摘AIM To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis(CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior.METHODS Twenty pathologically and clinically confirmed CMUSE patients(males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series(SBS; n = 25), computed tomography(CT) enterography(n = 21), magnetic resonance(MR) enterography(n = 2), and abdominopelvic CT(n = 18) images, focusing on enteric and perienteric manifestations. Any change in radiologic features during followup period was recorded. We evaluated clinical data including presenting symptoms, laboratory finding and presence of relapse from electronic medical records. Histopathologic findings were also evaluated. RESULTS The main symptoms were abdominal pain(n = 12) and anemia(n = 10). All patients showed small bowel strictures(n = 52, mean: 2.6 per patient) on initial CT/MR, located in the ileum(n = 47) or jejunum(n = 5). Strictures showed short-length(mean: 10.44 mm) and circumferential bowel wall thickening(mean: 5.56 mm) with layered enhancement(n = 48) that were also noted on initial SBS(n = 36) with shallow ulcers(n = 10). Some ulcerative lesions or wall thickening progressed into strictures on follow-up SBS/CT, and some strictures revealed recurrent ulceration on followup SBS. There were no penetrating disease features like fistula or abscess and no gastrointestinal tract involvement except the small bowel. Nine patients experienced disease recurrence(median relapse-free period: 32 mo) even post-operatively. Histopathologic features of surgically resected specimens were characterized as multiple superficial ulcerations confined to mucosa or submucosa and multiple strictures.CONCLUSION Under characteristic radiologic findings with multiple short-segmental strictures and/or shallow ulcers of the small intestine, CMUSE should be considered when assessing patients with recurrent abdominal pain and anemia. | Jiyoung Hwang Jin Sil Kim Ah Young Kim Joon Seok Lim Se Hyung Kim Min Ju Kim Mi Sung Kim Kyoung Doo Song Ji Young Woo | 2017 | World Journal of Gastroenterology2017，23，25： | 4 |
| 4 | Patterns of regional recurrence after curative D2 resection for stage III (N3) gastric cancer: Implications for postoperative radiotherapy显示文摘 | Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Chang Geol Lee Woong Sub Koom | 2012 | Radiotherapy and Oncology2012，，3： | 4 |
| 5 | Percutaneous radiofrequency ablation for early-stage hepatocellular carcinoma as a first-line treatment: long-term results and prognostic factors in a large single-institution series显示文摘 | Dongil Choi Hyo K. Lim Hyunchul Rhim Young-sun Kim Won Jae Lee Seung Woon Paik Kwang Cheol Koh Joon Hyoek Lee Moon Seok Choi Byung Chul Yoo | 2007 | European Radiology2007，，3： | 2 |
| 6 | Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer显示文摘Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal cancer.Methods:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal cancers.Endoscopic findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training group.Low expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training group.Higher p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient groups.Conclusions:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses. | Hyuk Hur Min Soo Cho Woong Sub Koom Joon Seok Lim Tae Il Kim Joong Bae Ahn Hoguen Kim Nam Kyu Kim | 2020 | Chinese Journal of Cancer Research2020，32，2： | 2 |
| 7 | Imaging findings of biliary and nonbiliary complications following laparoscopic surgery显示文摘 | Jin-Young Choi Myeong-Jin Kim Mi-Suk Park Joo Hee Kim Joon Seok Lim Young Taik Oh Ki Whang Kim | 2006 | European Radiology2006，，9： | 1 |
| 8 | Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis显示文摘 | Hyoung‐Mo Yang Seung‐Jea Tahk Hong‐Seok Lim Myeong‐Ho Yoon So‐Yeon Choi Byoung‐Joo Choi Xiong Jie Jin Gyo‐Seung Hwang Jin‐Sun Park Joon‐Han Shin | 2014 | Intervent2014，，3： | 1 |
| 9 | Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults显示文摘 | Han Seok Choi Kwang Joon Kim Kyoung Min Kim Nam Wook Hur Yumie Rhee Dae Suk Han Eun Jig Lee Sung-Kil Lim | 2010 | Calcified Tissue International2010，，3： | 1 |
| 10 | Defining the target volume for post-operative radiotherapy after D2 dissection in gastric cancer by CT-based vessel-guided delineation<!-- CT-based vessel-guided target volume delineation -->显示文摘 | Hong In Yoon Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Kyung Hwan Kim Woong Sub Koom | 2013 | Radiotherapy and Oncology2013，，： | 1 |
| 11 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 12 | Role of EUS and MDCT in the diagnosis of gastric submucosal tumors according to the revised pathologic concept of gastrointestinal stromal tumors显示文摘 | Jung-Ho Kang Joon Seok Lim Jie-Hyun Kim Woo Jin Hyung Yong Eun Chung Jin-Young Choi Mi-Suk Park Myeong-Jin Kim Ki Whang Kim | 2009 | European Radiology2009，，4： | 1 |
| 13 | Definitive chemoradiation therapy with capecitabine in locally advanced pancreatic cancer显示文摘 | Hyo Song Kim Seong Yoon Yi Hyun Jung Jun Jeeyun Lee Se Hoon Park Jong Kyun Lee Kyu Taek Lee Kwang Hyuck Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Young Suk Park Ho Yeong Lim Won Ki Kang Hee Chul Park Do Hoon Lim Joon Oh Park | 2010 | Anti-Cancer Drugs2010，，1： | 1 |
| 14 | Clinical parameters predictive of outcomes in sorafenib‐treated patients with advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Ho Yeong Lim Young Gon Kim Hyo Keun Lim Yang Won Min Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Liver Int2013，，6： | 1 |
| 15 | A phase II trial of gemcitabine plus capecitabine for patients with advanced pancreatic adenocarcinoma显示文摘 | Byeong-Bae Park Joon Oh Park Hyo Rak Lee Jeeyun Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Jong Kyun Lee Kyu Taek Lee Do Hoon Lim Young Suk Park Ho-Yeong Lim Won Ki Kang Keunchil Park | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 16 | A phase II trial of gemcitabine plus capecitabine for patients with advanced pancreatic adenocarcinoma显示文摘 | Byeong-Bae Park Joon Oh Park Hyo Rak Lee Jeeyun Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Jong Kyun Lee Kyu Taek Lee Do Hoon Lim Young Suk Park Ho-Yeong Lim Won Ki Kang Keunchil Park | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 17 | Radiation therapy for abdominal lymph node metastasis from hepatocellular carcinoma显示文摘 | Young Je Park Do Hoon Lim Seung Woon Paik Kwang Cheol Koh Joon Hyoek Lee Moon Seok Choi Byung Chul Yoo Hee Rim Nam Dong Ryul Oh Won Park Yong Chan Ahn Seung Jae Huh | 2006 | Journal of Gastroenterology2006，，11： | 1 |
| 18 | Preoperative Imaging of Sentinel Lymph Modes in Gastric Cancer UJsing CT Lymphography显示文摘 | Woo Jin Hyung Yong Soo Kim Joon Seok Lim | | 0，，03： | 1 |
| 19 | Phase II study of docetaxel and cisplatin combination chemotherapy in metastatic gastric cancer显示文摘 | Keon Woo Park Jin Seok Ahn Young Suk Park Jeeyun Lee Jung Hoon Kang Joon Oh Park Ho Yeong Lim Young-Hyuck Im Won Ki Kang Keunchil Park Soon Il Lee | 2007 | Cancer Chemotherapy and Pharmacology2007，，1： | 1 |
| 20 | Smooth muscle progenitor cells from peripheral blood promote the neovascularization of endothelial colony-forming cells显示文摘 | Hyung Joon Joo Ha-Rim Seo Hyo Eun Jeong Seung-Cheol Choi Jae Hyung Park Cheol Woong Yu Soon Jun Hong Seok Chung Do-Sun Lim | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
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