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| 1 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 2 | Hemodynamic disturbances in premature infants born after chorioamnionitis:Association with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 3 | Hemodynamic disturbances in premature infants bern after chorioamnionitis:association with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 4 | Novel Synthesis of Phenyl-3-butynoaiccid, A New Inhibitor and Alternate Substrate of Pyruvate Decarboxylase显示文摘 | CH/U C C JORDAN F | 1994 | J Org Chem1994，59，： | 1 |
| 5 | Hemodynamic dis- turbances in premature infants born after chorioamnionitis: asso- ciation with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 6 | Motivation by positive or negative role models:Regulatory focus deter- mines who will best inspire us显示文摘 | Lockwood P Jordan CH Kunda Z | 1997 | Academy of Management Journal1997，40，1： | 1 |
| 7 | Hemodynamic dis- turbances in premature infants born after chorioamnionitis : asso- ciation with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 8 | Relationship between theinoculum dose of streptococcus pneumoniae and pneumonia onset ina rabbit model显示文摘 | Yershov AL Jordan BS Guymon CH | 2005 | Eur Respir J2005，25，： | 1 |
| 9 | Relationship between the inoculum dose of streptococcus pneumoniae and pneumonia onset in a Rabbit model显示文摘 | Yershov AL Jordan BS Guymon CH | 2005 | Eur Respir J2005，25，： | 1 |
| 10 | Overexpression of matrix metalloproteinase - 1 and - 9 mRNA is associated with progression of oral dysplasia to cancer显示文摘 | Jordan RC Macabeo - Ong M Shiboski CH | 2004 | Clin Cancer Res2004，10，： | 1 |
| 11 | Types of high self-esteemand prejudice: how implicit self-esteem relates to ethnic discrimination among high self-esteem individuals显示文摘 | Jordan CH Spencer SJ Zanna MP | 2005 | Pers Soc Psychol Bull2005，31，5： | 1 |
| 12 | Peyronie's disease:New concepts in etiology,diagnosis and treatment显示文摘 | Jordan CH Celbard MK | 1999 | Contemporary Urol1999，11，： | 1 |
| 13 | Secure and Defensive High Self-esteem 显示文摘 | Jordan CH Spencer S J Zanna MP | 2003 | J Pers Soc Psychol2003，85，5： | 1 |
| 14 | Relationship between the inoculum dose of Streptococcus pneumonia and pneumonia onset in a rabbit model显示文摘 | Yershov AL Jordan BS Guymon CH | 2005 | Eur Respir J2005，25，4： | 1 |
| 15 | Overexpression of matrix metalloproteinase-1 and-9 mRNA is associated with progression of oral dysplasia to cancer显示文摘 | Jordan RC Macabeo-Ong M Shiboski CH | 2004 | Clin Cancer Res2004，10，19： | 1 |
| 16 | Overex- pression of matrix metalloproteinase- 1 and- 9 mRNA is associated with progression of oral dysplasia to cancer 显示文摘 | Jordan RC Macabeo-Ong M Shiboski CH | 2004 | Clin Cancer Res2004，10，19： | 1 |
| 17 | Hemodynamic disturbances in premature infants born after cborioamnionitis: association with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 18 | Relationship between the inoculum dose of streptococcus pneumoniae and pneumonia onset in a rabbit model显示文摘 | Yershov AL Jordan BS Guymon CH | 2005 | Eur Respir J2005，25，： | 1 |
| 19 | Hemodynamic disturbances in premature infants born after chorioamnionitis:association with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 20 | Hemodynamie disturbances in premature infants bem after ehorioamnionitis:association with cord blood eytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
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