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| 1 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Jorge Saba Alberto Perez-Castilla Manoel Galvao Neto Michael D. Crowell | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 4 | 医学教育中计算机动画应用的文献回顾显示文摘计算机动画可以显示动态的变化,表达抽象的概念,因此医学教育中越来越多地应用计算机动画。然而,动画的优越性会因学习者个体差异如知识储备和空间认知能力的不同而不同,动画并非一直有效。本文介绍了相关的研究成果,描述了动画在医学教育中的应用,根据认知负荷理论为动画的设计和使用提供了原则,为未来研究提供了方案。 | Jorge G Ruiz 梁进 | 2010 | 复旦教育论坛2010，8，3： | 2 |
| 5 | The effect of the operating point on the pressure fluctuations at the blade passage frequency in the volute of a centrifugal pump显示文摘 | Jorge L P Jose G Joaquin F | 2002 | Journal of Fluids Engineering2002，124，3： | 1 |
| 6 | Imaging electron wave functions of quantized energy levels in carbon nanotubes 显示文摘 | LIESBETH C V JEROEN W G JORG W J | 1999 | Science1999，283，： | 1 |
| 7 | Major depression following traumatic brain injury显示文摘 | JORGE R E ROBINSON R G MOSER D | 2004 | Arch Gen Psychiatry2004，61，1： | 1 |
| 8 | Psychological distress among Latino family caregivers of adults with schizophrenia : The roles of burden and stigma raymond cortez显示文摘 | Sandy M Magaa Jorge I Ramirez Garcia Maria G Hernandez | 2007 | Psychiatric Services2007，58，3： | 1 |
| 9 | Thrombosis in systemic lupus erythematosus and other autoimmune diseases of recent onset显示文摘 | Juanita R D Icellini G S Jorge S G | | 0，，01： | 1 |
| 10 | A review of volatile analytical methods for determining the botanical origin of honey 显示文摘 | Luis F C G Jorge A P Louis S S | 2007 | Food Chem2007，103，： | 1 |
| 11 | A study of habitat fragmentation in Southeastern Brazil using remote sensing and geographic information systems(GIS)显示文摘 | Jorge L A B Garcia G J | 1997 | Forest Ecology and Management1997，98，： | 1 |
| 12 | Fiberoptic hot-wire flowmeter based on a metallic coated hybrid long period grating/fiber Bragg grating structure显示文摘 | Caldas P Jorge P A S Rego G | 2011 | Applied Optics2011，50，17： | 1 |
| 13 | Performance evaluation of an activated sludge system for removing petroleum hydrocarbons from oilfield produced water 显示文摘 | Tellez G T Nirmalakhandan N Jorge G L | 2002 | Advances in Environ- mental Research2002，，6： | 1 |
| 14 | Sulfide and ammonium oxidation, acetate mineralization by denitrification in a multipurpose UASB reactor 显示文摘 | RICARDO B C JORGE G RAM6N M P | 2011 | Bioresource Technology2011，102，： | 1 |
| 15 | Evaluation of approximatem ethods to estimate maximum inelastic displacement demands显示文摘 | MIRANDA E JORGE R G | 2002 | Earthquake Engineering and Structural Dynamics2002，31，12： | 1 |
| 16 | Ovarian response to follicle stimulating hormone depends on the FSH receptor genotype显示文摘 | Maritza PM Jorg G Herman MB | 2000 | J Clin Endocrinol Metab2000，85，9： | 1 |
| 17 | Wine and grape polyphenols-a chemical perspective 显示文摘 | JORGE G FERNANDA B | 2011 | Food Research International2011，44，10： | 1 |
| 18 | Repetitive transeranial magnetic stimulation as treatment of poststroke depression : A prelimi- nary study显示文摘 | Jorge R E Robinson R G Tateno A | 2004 | Biol Psychiatry2004，55，： | 1 |
| 19 | Effects of weight lifting training combined with plyometric exercise on physical fitness,body composition,and knee extension velocity during kicking in football显示文摘 | JORGE P G HUGO O SAFIRA D G | | 0，，： | 1 |
| 20 | The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF 1 1显示文摘 | Rosato R R Jorge A A Steven G | 2003 | Cancer Res2003，63，13： | 1 |
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