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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 3 | Spinal mechanisms contribute to analgesia prodused by epidural sufentanil clmbined with bupivacaine far postoperative analgesia显示文摘 | Joris J L Jacob E A Sessler D I | 2003 | Anesth Analg2003，97，： | 1 |
| 4 | Hemodynamic changes induced by laparoscopy and their endocrine correlates: effects of clonidine显示文摘 | JORIS J L CHICHE J D CANIVET J L | 1998 | J Am Coil Cardiol1998，32，5： | 1 |
| 5 | Hem odynam ic changes during laparoscopic cholecystectomy显示文摘 | Joris J L Noirot D P Legrand M J | 1993 | Aneath Analg1993，76，5： | 1 |
| 6 | Pain after laparoscopic cholecystectomy:characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，： | 1 |
| 7 | Time-course of oocyte activation, pronucleus formation and cleavage in human oocytes fertilized by intracytoplasmic sperm injection 显示文摘 | NAGY ZP LIU J JORIS H | 1994 | Hum Reprod1994，9，9： | 1 |
| 8 | Acute renal failure requiring haemodialysis after high doses percutaneous acetic acid injection for hepatocellular carcinoma显示文摘 | Van Hoof M Joris J P Horsmans Y | 1999 | Acta Gastroenterol Belg1999，62，1： | 1 |
| 9 | Pain after laparoscopic cholecystectomy:characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，2： | 1 |
| 10 | Pain after laparoscopic cholecystectony; characteristics and effect of intraperitoneal bupivaeaine 显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，： | 1 |
| 11 | Analysis of 76 total fertilization failure cycles out of 2732 intracytoplasmic sperm injection cycles 显示文摘 | Liu J Nagy Z Joris H | 1995 | Hum Reprod1995，10，： | 1 |
| 12 | The result of intracytoplasmic sperm injection is not related to any of the three basic sperm parameters显示文摘 | Nagy ZP Liu J Joris H | 1995 | Hum Reprod1995，10，5： | 1 |
| 13 | The result of intracytoplasmic sperm injection is not related to any of the three basic sperm parameters显示文摘 | Nagy ZP Liu J Joris H | 1995 | Hum Reprod1995，10，3： | 1 |
| 14 | Efficacy of nonsteroidal antiinflammatory drugs in postoperative pain显示文摘 | JORIS J | 1996 | Acta Anaesthesiol Bleg1996，47，3： | 1 |
| 15 | An experimental Gyro-TWT显示文摘 | SYMONS R S JORY H R HEGJ1 S J | 1981 | 1EEE Trans Microwave Theory Tech1981，29，： | 1 |
| 16 | Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes显示文摘 | NAGY Z P JORIS H LIU J | | 0，，12： | 1 |
| 17 | Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia显示文摘 | Liu J Nagy Z Joris H | 1995 | Hum Reprod1995，10，3： | 1 |
| 18 | Pain after laparoscopic cholecystectomy:Characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Pacis Po | 1995 | Anesth Analg1995，81，： | 1 |
| 19 | Use of ropivacaine for peridural postoperative analgesia显示文摘 | Senard M Joris J | 2002 | Ann Fr Anesth Reanim2002，21，7： | 1 |
| 20 | Hemodynamic changes during laparoscopic cholecystectomy 显示文摘 | Joris JL Noirot DP Legrand M J | 1993 | Anesth Analg1993，76，5： | 1 |
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