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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 3 | Single step EUS-Guided endoscopic treatment for sterile pancreatic collec-tions:a single-center experience显示文摘 | Jose C Ardengh Djaima E Coelho Jose F | 2008 | Digestive Diseases2008，26，： | 1 |
| 4 | Natural antioxidants from residual source显示文摘 | Andres M Jose M C Daniel F | 2001 | Food Chem2001，72，： | 1 |
| 5 | Evaluation of estrogen receptor α and β and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki- 67 in breast cancers显示文摘 | Fabiola E R Jose R F C Joice F | 2008 | Human Pathology2008，39，5： | 1 |
| 6 | Pyrolysis of high-density polyethylene in free-fall reactors in series显示文摘 | Jose' F M Ce'sar B Jesu's C | 2006 | Energy & Fuels2006，20，： | 1 |
| 7 | Changes in growth and in solute concentrations in sorghum leaves and roots during salt stress recovery 显示文摘 | Claudivan F de L Jose C Mareo Antonio O | 2005 | Environmental and Experimental Botany2005，54，： | 1 |
| 8 | Docking and quantum mechanic studies on chlolinesterases and their inhibitiors 显示文摘 | Jose C B Cesar F S Jesus M C | 2007 | Eur J Medicinal Chem2007，42，1： | 1 |
| 9 | The magnitude of copigmentation in the color of aged red wines made in the Canary Islands 显示文摘 | Jacinto D Marta C L Jose F | 2007 | Eur Food Res Technol2007，224，： | 1 |
| 10 | Influence of the size of aortic valve prostheses on hemodynamics and change in left ventricular mass: implications for the surgical menagement of aortic stenosis显示文摘 | JOSE R C J JOSE M G A MARINO V F | 1996 | J Thorac Cardiovasc Surg1996，112，1： | 1 |
| 11 | Knowledge modelling for the motion detection task:the algorithmic lateral inhibition method显示文摘 | JOSE M ANA E D ANTONIO F C | 2004 | Expert Systems with Applications2004，27，： | 1 |
| 12 | Food dehydration and product structure显示文摘 | JOSE M A IAMPARO C PEDRO F | 2003 | Trends in Food Science & Technology2003，，4： | 1 |
| 13 | Group 6 metal oxide carbon aerogels: Their syn- thesis, characterization and catalytic activity in the skeletal isomerization of 1 butene显示文摘 | CARLOS M C JOSE F M H JOSE R U | 1999 | Appl Catal A: General1999，183，： | 1 |
| 14 | High- strength steel development for pipelines: a Brazilian perspective 显示文摘 | Ivanide S B de Luis F G S Jose C G T | 2005 | Metallurgical and Materials Transactions A2005，36，44： | 1 |
| 15 | An efficient approach to the traveling salesman problem using self-organizing maps显示文摘 | Frederico C V Adiao D D N & Jose A F | 2003 | International Journal of Neural Systems2003，13，2： | 1 |
| 16 | High phosphorus diet induces vascular calcification,a related decrease in bone mass and changes in the aortic gene expression显示文摘 | Pablo R Natalia C Jose L F | 2010 | Bone2010，46，： | 1 |
| 17 | Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone显示文摘 | Jose C F Kathleen A J Maria W S | 2007 | J Clin Endocnnol Metab2007，92，： | 1 |
| 18 | Evaluation of the efficacy of triple therapy regimen for Helicobacter pylori eradication in gastrectomized patients with gastric adenocarcinoma显示文摘 | Jose Luiz Bertoli Neto Laercio Gomes Louren?o Cícero Fernando Bertoli Fábio Samsonowski Ulbrich Antoninho Ricardo Sabbi Alexandre Galv?o Bueno | 2006 | Gastric Cancer2006，，4： | 1 |
| 19 | Protoplast formation and regeneration from Streptomyces clavuligerus NRRL 3585 and elavulanie acid production 显示文摘 | Maria das G C Jose L L F Galba M C T | 2002 | Brazilian Journal of Microbiology2002，33，： | 1 |
| 20 | Auction design in day-ahead electricity markets显示文摘 | Javier C Oscar C Jose I F | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
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