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您的检索式：作者名="Jose D.Debes"
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| 1 | Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant显示文摘Treatment modalities for hepatocellular carcinoma(HCC)vary from surgical techniques and interventional radiologic strategies to systemic therapy.For the latter,the use of immune checkpoint inhibitors(ICIs)has gained popularity due to successful trials showing increased survival.In patients who have undergone liver transplantation,recurrence of HCC poses a significant challenge.There is indeed considerable debate on the efficacy and safety of ICI use in liver transplant recipients due to competing immune interests in maintaining a healthy graft and combating the tumor.Recent reports and case series have highlighted a role for the type of immune therapy,timing of therapy,tissue expression of PD-1 and modulation of immunosuppression,in the understanding of the efficacy and risks of ICIs for HCC in liver transplant.In this article,we appraise the available literature on the usage of ICIs for HCC in liver transplant recipients and provide perspectives on immune concerns as well as potential recommendations to consider during the management of such complex cases. | Chimaobi M.Anugwom Thomas M.Leventhal Jose D.Debes | 2022 | Hepatoma Research2022，8，1： | 1 |
| 2 | Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa:a focus on surveillance显示文摘Human immunodeficiency virus(HIV)and hepatitis-B virus(HBV)infections are weighty public health challenges,especially in the African continent.The direct carcinogenic effect of HBV means that it remains a potent cause of early-onset hepatocellular carcinoma(HCC)in Sub-Saharan Africa(SSA),where it causes significant morbidity and mortality.The presence of HIV infection in HBV-infected patients poses a complicating factor,as coinfection has been shown to hasten the progression of liver disease to cirrhosis and HCC,and often resulting in early-age hepatocarcinogenesis with consequent late diagnosis and lower survival.In this review,we discuss this unique conundrum,the epidemiology of HIV-HBV coinfection in SSA,its effect on liver disease and development of HCC,as well as practices and barriers to HCC surveillance in this distinct population.We propose a way forward to curb this considerable health burden focusing on reduction of disease stigma,the need for easy-to-measure biomarkers,and implementation of large prospective studies in this population. | Qian Wan Chimaobi Anugwom Hailemichael Desalegn Jose D.Debes | 2022 | Hepatoma Research2022，8，1： | 0 |
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