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| 1 | The different root apex zones contribute to drought priming induced tolerance to a reoccurring drought stress in wheat显示文摘Drought priming is a promising approach to improve tolerance to further drought in wheat.The root apex plays important roles in drought however,its contribution to drought priming remains unknown.To provide mechanistic insights into this process,the transcriptomes and proteomes at three different zones along the root axis under drought stress were analyzed.Physiological assessment of root growth indicated that priming augmented roots growth in response to drought and also the levels of protective proline and glycine betaine.Scanning across the proximal to the distal zones of the root apex indicated increases the transcription of genes involved in primary and secondary metabolism.Conversely,genes related to translation,transcription,folding,sorting and degradation,replication and repair were increased in the apex compared to the proximal zone.A single drought episode suppressed their expression but prior drought priming served to maintain expression with recurrent drought stress.The differentially primed responses genes were mainly involved in the pathways related to plant hormone signaling,stress defense and cell wall modification.The prediction of regulatory hubs using Cytoscape implicated signaling components such as the ABA receptor PYL4 as influencing antioxidant status and the cell cycle.Based our integrative transcriptomic-proteomic assessments we present a model for drought priming protected plant hormone signaling transduction pathways to drive the cell cycle and cell wall loosening to confer beneficial effects on roots to counter the effects of drought.This model provides a theoretical basis for improvement of drought tolerance in wheat,via an increased understanding of drought priming induced drought tolerance. | Xiao Wang Jing Chen Jiakun Ge Mei Huang Jian Cai Qin Zhou Tingbo Dai Luis Alejandro Jose Mur Dong Jiang | 2021 | The Crop Journal2021，9，5： | 2 |
| 2 | Nanog Is the Gateway to the Pluripotent Ground State显示文摘 | Jose Silva Jennifer Nichols Thorold W. Theunissen Ge Guo Anouk L. van Oosten Ornella Barrandon Jason Wray Shinya Yamanaka Ian Chambers Austin Smith | 2009 | Cell2009，，： | 1 |
| 3 | Nanog Is the Gateway to the Pluripotent Ground State显示文摘 | Jose Silva Jennifer Nichols Thorold W. Theunissen Ge Guo Anouk L. van Oosten Ornella Barrandon Jason Wray Shinya Yamanaka Ian Chambers Austin Smith | 2009 | Cell2009，，4： | 1 |
| 4 | Amethodfor calibration and validation subset partitioning显示文摘 | GalvaoRKH Araujo M C U Jose GE | 2005 | Talanta2005，67，： | 1 |
| 5 | Soybean susceptibility to manufactured nanomaterials with evidence for food quality and soil fertility interruption显示文摘 | John H. Priester Yuan Ge Randall E. Mielke Allison M. Horst Shelly Cole Moritz Katherine Espinosa Jeff Gelb Sharon L. Walker Roger M. Nisbet Youn-Joo An Joshua P. Schimel Reid G. Palmer Jose A. Hernandez-Viezcas Lijuan Zhao Jorge L. Gardea-Torresdey Patri | 2012 | Proceedings of the National Academy of Sciences2012，，37： | 1 |
| 6 | Multiple Emulsions Controlled by Stimuli‐Responsive Polymers显示文摘 | Lucie Besnard Frédéric Marchal Jose F. Paredes Jean Daillant Nadège Pantoustier Patrick Perrin Patrick Guenoun | 2013 | Adv. Mater2013，，20： | 1 |
| 7 | Nanog Is the Gateway to the Pluripotent Ground State显示文摘 | Jose Silva Jennifer Nichols Thorold W. Theunissen Ge Guo Anouk L. van Oosten Ornella Barrandon Jason Wray Shinya Yamanaka Ian Chambers Austin Smith | 2009 | Cell2009，，4： | 1 |
| 8 | Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency显示文摘 | Jian Yang Anouk L. van Oosten Thorold W. Theunissen Ge Guo Jose C.R. Silva Austin Smith | 2010 | Cell Stem Cell2010，，3： | 1 |
| 9 | Intravascular ultrasound assessment of the incidence and predictors of edge dissections and intramural hematomas after drug-eluting stent implantation显示文摘Objective We used intravascular ultrasound (IVUS) to assess incidence, predictors, morphology, and angiographic findings of edge dissections and intramural hematomas after drug-eluting stent (DES) implantation. Methods We studied 887 patients with 1 045 non-in-stent restenosis lesions in 977 native arteries undergoing DES implantation with IVUS imaging, and compared the dissected stent end to the non-dissected stent end. Results Eighty-two dissections were detected; 51.2% (42/82) involved the proximal and 48.8% (40/82) the distal stent edge. When compared to the non-dissected stent end, residual plaque area [(8.0±4.3) mm2 vs (5.2±3.0) mm2, P<0.01], plaque burden [(52±12)% vs (36±15)%, P<0.01], plaque eccentricity (8.4±5.5 vs 4.0±3.4, P<0.01), and stent edge symmetry (1.17±0.11 vs 1.14±0.08, P=0.02) were larger; plaque burden≥50% was more frequent (62% vs 17%, P<0.01) and calcium deposits (52.5% vs 35.6%, P=0.03) more common; and the lumen/stent area (0.86±0.16 vs 1.02±0.18, P<0.01) was smaller in the stent dissected end. Independent predictors of stent edge dissection were residual plaque eccentricity (OR=1.3, P<0.01) and residual plaque burden≥50% (OR=7.3, P<0.01). Intramural hematomas occurred in 34.1% (28/82) of dissections.Independent predictors of intramural hematomas were plaque eccentricity (OR=1.4, P=0.005), plaque burden≥50% (OR=7.1, P=0.02), and mean lumen diameter to stent diameter ratio (OR=0.37, P=0.04).Concluslon IVUS identified edge dissections after 9.4% of DES implantations. Residual plaque eccentricity and significant plaque burden predicted coronary stent edge dissections. Dissections in less diseased reference segments with an arc of normal vessel wall (greater plaque eccentricity) more often evolved into an intramural hematoma. | Gary S.Mintz Stéphane G.Carlier Jose de Ribamar Costa Jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone Jeffrey W.Moses GE Junbo Martin B.Leon | 2007 | 上海医学2007，30，S1： | 0 |
| 10 | Assessment of inconclusive left main coronary lesions: lessons from an intravascular ultrasound study显示文摘Objective Angiographic assessment of a left main coronary artery (LMCA) stenosis is often difficult and unreliable. Intravascular ultrasound (IVUS) assessment of absolute lumen dimensions has been shown to correlate with fractional flow reserve (FFR) and to predict clinical outcome in patients with a LMCA stenosis. Methods During 21 months period (October, 2004 to July, 2006), 153 patients (Ostial lesions, n=47; Non-ostial lesion, n=106) underwent IVUS evaluation specifically to assess the severity of an angiographically inconclusive LMCA narrowing. IVUS analysis included plaque morphology; external elastic membrane (EEM), lumen, plaque cross-sectional areas (CSA), plaque burden (plaque CSA/ EEM) and remodeling index (lesion EEM CSA/reference EEM CSA). Results Overall, minimum lumen area (MLA) and diameter (MLD) and plaque burden measured 8.2 mm2, 2.6 mm, and 59.3 %, respectively. An MLA<6.0 mm2 (which has been shown to correlate with a FFR <0.75) was seen 41.5% in ostial lesions and 44.5% in non-ostial lesions. In particular, ostial LMCA lesions had a larger MLA and a smaller plaque burden than non-ostial lesions (Table). Conclusions Patients referred for LMCA evaluation commonly have insignificant narrowing. Negative remodeling was prominent at the LMCA ostium. These patients deserve IVUS assessment before revascularization. | Gary S.Mintz Stéphane G.Carlier Jose de Ribamar Costa Jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone Jeffrey W.Moses Junbo Ge Martin B.Leon | 2007 | 上海医学2007，30，S1： | 0 |
| 11 | Volumetric intravascular ultrasound comparisons of drug-eluting stent thrombosis and in-stent restenosis显示文摘Objectives We compared intravascular ultrasound (IVUS) findings of drug-eluting stent (DES)-treated lesions that developed stent thrombosis versus in-stent restenosis (ISR) to identify underlying mechanical differences. Methods IVUS findings in 15 post-DES thrombosis patients were compared with 45 matched ISR patients who had no evidence of stent thrombosis. Results Minimum stent area [MSA, (3.7±0.8) mm2 vs (4.9±1.8) mm2, P=0.01], minimum stent diameter [(1.9±0.3) mm vs (2.3±0.4) mm, P=0.005], mean stent area [(5.2±0.8) mm2 vs (7.2±2.1) mm2, P<0.01], and both focal [MSA/reference lumen area, (54.7±15.9)% vs (75.0±20.1)%, P=0.001] and diffuse stent expansion [mean stent area/reference lumen area, (76.6±23.0)% vs (110.3±23.3)%, P<0.01] were significantly smaller in the stent thrombosis group (vs the ISR group). An MSA <4.0 mm2 (73.3% vs 35.6%, P=0.01) or <5.0 mm2 (86.7% vs 53.3%, P=0.02) was more often found in the stent thrombosis group (vs the ISR group). The MSA site occurred more frequently in the proximal stent segment within the stent thrombosis group compared to the ISR group (60% vs 24.4%, P=0.01). There were no differences in edge dissection, stent fracture, or stent-vessel wall malapposition between the two groups. Independent predictors of stent thrombosis were diffuse stent expansion (OR=1.5, P=0.03) and proximal location of the MSA site (OR=12.7, P=0.04). Conclusion DES-treated lesions that develop thrombosis or restenosis are often underexpanded. Underexpansion appears to be more severe in DES-thrombosis lesions. Lesions with diffuse underexpansion and a proximal (vs distal) underexpanded MSA site are more predisposed to thrombus formation than ISR. | Gary S.Mintz Stéphane G.Carlier Jose de Ribamar Costa Jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone Jeffrey W.Moses GE Junbo Martin B.Leon | 2007 | 上海医学2007，30，S1： | 0 |
| 12 | GIS-based spatial prediction of landslide using road factors and random forest for Sichuan-Tibet Highway显示文摘Accurate evaluation of landslide susceptibility is very important to ensure the safe operation of mountain highways.The Sichuan-Tibet Highway,which traverses the east of the Tibetan Plateau,frequently encounters natural hazards.Previous studies generally use statistical methods to analyze the hazards along the Sichuan-Tibet Highway.In this research,we present two road factors,namely aspect to road and road profile to increase the accuracy of landslide susceptibility mapping by considering the influence of landslide movement direction on road.First,the aspect to road,which represents the impact of different landslide movement directions on the highway,was extracted by combining road direction with mountain aspect.Then,the road profile,which reflects the subgrade structure between the road and surrounding mountains,was extracted according to the terrain data.Finally,the landslide susceptibility maps were produced based on the random forest(RF)method by using 473 landslides and 10 conditioning factors,including road factors(aspect to road,road profile)and primitive factors(slope,aspect,curvature,relief amplitude,peak ground acceleration,crustal movement velocity,faults,rainfall).The area under the receiver operating characteristic curve(AUC)and the Gini importance were used to evaluate the performance of proposed road factors.The AUC values on two groups that add road factors and only use primitive factors were 0.8517 and 0.8243,respectively.The Gini importance indicated that road profile(0.123)and aspect to road(0.116)have a significant contribution to landslides compared with the primitive factors.The results of multi-collinearity analysis and frequency ratio confirmed the suitability of the road factors for predicting hazards along the highway. | YE Cheng-ming WEI Rui-long GE Yong-gang LI Yao Jose Marcato JUNIOR Jonathan LI | 2022 | Journal of Mountain Science2022，19，2： | 0 |
| 13 | Stay in touch with the endoplasmic reticulum显示文摘The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic cells.As a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling events.Here,we systematically review recent advances and converging themes on ER-involved organellar contact.The molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized. | Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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