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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) includes two entities, Crohn’s disease and ulcerative colitis. Both are chronic conditions with frequent complications and surgical procedures and a great impact on patient’s quality of life. The thiopurine antimetabolites azathioprine and 6-mercaptopurine are widely used in IBD patients. Current indications include maintenance therapy, steroid-dependant disease, fistula closure, prevention of infliximab immunogenicity and prevention of Crohn’s disease recurrence. Surprisingly, the wide use of immunosuppressants in the last decades has not decreased the need of surgery, probably because these treatments are introduced at too late stages in disease course. An earlier use of immunossupressants is now advocated by some authors. The rational includes: (1) failure to modify IBD natural history of present therapeutic approach, (2) demonstration that azathioprine can induce mucosal healing, a relevant prognostic factor for Crohn’s disease and ulcerative colitis, and (3) demonstration that early immunossupression has a very positive impact on pediatric, recently diagnosed Crohn’s disease patients. We are now awaiting the results of new studies, to clarify the contribution of azathioprine, as compared to infliximab (SONIC Study), and to demonstrate the usefulness of azathioprine in recently diagnosed adult Crohn’s disease patients (AZTEC study). | María Josefina Etchevers Montserrat Aceituno Miquel Sans | 2008 | World Journal of Gastroenterology2008，14，36： | 10 |
| 3 | Management of critically ill patients with diabetes显示文摘Disorders of glucose homeostasis, such as stress-induced hypoglycemia and hyperglycemia, are common complications in patients in the intensive care unit. Patients with preexisting diabetes mellitus(DM) are more susceptible to hyperglycemia, as well as a higher risk from glucose overcorrection, that may results in severe hypoglycemia. In critically ill patients with DM, it is recommended to maintain a blood glucose range between 140-180 mg/d L. In neurological patients and surgical patients, tighter glycemic control(i.e., 110-140 mg/d) is recommended if hypoglycemia can be properly avoided. There is limited evidence that shows that critically ill diabetic patients with a glycosylated hemoglobin levels above 7% may benefit from looser glycemic control, in order to reduce the risk of hypoglycemia and significant glycemic variability. | Livier Josefina Silva-Perez Mario Alberto Benitez-Lopez Joseph Varon Salim Surani | 2017 | World Journal of Diabetes2017，8，3： | 10 |
| 4 | From leaf to whole-plant water use efficiency(WUE)in complex canopies:Limitations of leaf WUE as a selection target显示文摘Plant water use efficiency(WUE) is becoming a key issue in semiarid areas, where crop production relies on the use of large volumes of water. Improving WUE is necessary for securing environmental sustainability of food production in these areas. Given that climate change predictions include increases in temperature and drought in semiarid regions,improving crop WUE is mandatory for global food production. WUE is commonly measured at the leaf level, because portable equipment for measuring leaf gas exchange rates facilitates the simultaneous measurement of photosynthesis and transpiration. However,when those measurements are compared with daily integrals or whole-plant estimates of WUE, the two sometimes do not agree. Scaling up from single-leaf to whole-plant WUE was tested in grapevines in different experiments by comparison of daily integrals of instantaneous water use efficiency [ratio between CO2assimilation(AN) and transpiration(E); AN/E] with midday AN/E measurements, showing a low correlation, being worse with increasing water stress. We sought to evaluate the importance of spatial and temporal variation in carbon and water balances at the leaf and plant levels. The leaf position(governing average light interception) in the canopy showed a marked effect on instantaneous and daily integrals of leaf WUE. Night transpiration and respiration rates were also evaluated, as well as respiration contributions to total carbon balance. Two main components were identified as filling the gap between leaf and whole plant WUE: the large effect of leaf position on daily carbon gain and water loss and the large flux of carbon losses by dark respiration. These results show that WUE evaluation among genotypes or treatments needs to be revised. | Hipólito Medrano Magdalena Tomás Sebastià Martorell aume Flexas Esther Hernández Joan Rosselló Alicia Pou José-Mariano Escalona Josefina Bota | 2015 | The Crop Journal2015，3，3： | 9 |
| 5 | Monoclonal gammopathy of renal significance:Diagnostic workup显示文摘The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always available, even in tertiary central hospitals. This review will discuss the clinical presentation, pathologic features, treatment, prognosis and common diagnostic difficulties of these entities. | Sofia O Correia Sofia Santos Jorge Malheiro António Cabrita La Salete Martins Josefina Santos | 2017 | World Journal of Nephrology2017，6，2： | 4 |
| 6 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 7 | Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida:Influence of zinc,cadmium and nickel显示文摘This study investigated the adsorption of Hg(Ⅱ) on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn(II),Cd(Ⅱ) and Ni(II).The two biosorbents reached the same maximum sorption capacity (q m = 0.8 mmol/g) for mercury.U.pinnatifida showed a greater affinity (given by the coefficient b of the Langmuir equation) for mercury compared to M.pyrifera (4.4 versus 2.7 L/mmol).Mercury uptake was significantly reduced (by more than 50%) in the presence of competitor heavy metals such as Zn(II),Cd(II) and Ni(Ⅱ).Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous distributed.The analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg(Ⅱ) binding occurred on S=O (sulfonate) and N-H (amine) functional groups. | Josefina Plaza Marisa Viera Edgardo Donati Eric Guibal | 2011 | Journal of Environmental Sciences2011，23，11： | 3 |
| 8 | Resource-sharing strategies in ecotypes of the invasive clonal plant Carpobrotus edulis: specialization for abundance or scarcity of resources显示文摘Aims Carpobrotus edulis(L.)N.E.Br.is known to invade many coastal ecosystems around the world,and it has been considered as one of the most severe threats to numerous terrestrial plant communi-ties.Therefore,the study of the relationships between life-history traits that may favour its invasiveness and the invasibility of the environments is necessary to improve our knowledge about inva-sion success.In this research,we specifically tested the effects of physiological integration in genotypes from contrasting habitats,where the importance of integration is expected to differ.Thus,the main objective of this work was to detect the presence of adaptive plasticity in the capacity for clonal integration in this aggressive invader.Methods In a greenhouse experiment,we compared the performance,in terms of growth and photochemical efficiency,of two C.edulis ecotypes.Connected and severed ramet pairs from coastal sand dunes and rocky coast habitats were grown in substrates of different quality and heterogeneity.Important Findings Our study clearly indicates that clonal integration improves growth and photosynthetic efficiency in the aggressive invader C.edulis.Two differ-ent aspects of clonal integration determine site-specific strategies in this species in order to optimize its successful propagation in a particular habitat.We demonstrated that the adaptation of C.edulis to local envi-ronments has led to a differential selection of two complex clonal traits associated with the capacity for clonal integration.In patchy sand dunes,C.edulis has evolved ecotypes with ramets highly plastic in patterns of biomass allocation,which allows ramets to specialize in the acquisi-tion of the resource that is locally most abundant,i.e.,a spatial division of labour among ramets.However,in the harsher rocky coast habitats,local adaptation produced highly integrated ecotypes,where resource sharing is not combined with a specialization of resource acquisition. | Josefina G.Campoy Rubén Retuerto Sergio R.Roiloa | 2017 | Journal of Plant Ecology2017，10，4： | 3 |
| 9 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 10 | Efficient diborane-mediated synthesis of phthalocyanines carrying amino groups near the macrocycle显示文摘 | Gabriela A. Gauna Diego Cobice Josefina Awruch | 2012 | Polyhedron2012，，1： | 2 |
| 11 | Determination of germanium (Ⅳ) in sulphide ores by differential pulse polarography in pyrogallol-sulfuric acid media显示文摘 | JULIO CESAR AGUILAR JOSEFINA DE GYVES | 1995 | Analytica Chimica Acta1995，306，： | 1 |
| 12 | Enhanced electrochemical detection of heavy metals at heated graphite nanoparticle-based screenprinted electrodes显示文摘 | GEMMA A JOSEFINA P ARBEN M | 2011 | Journal of Materials Chemistry2011，21，12： | 1 |
| 13 | Evaluation of Ciba Coming ACS: 180^TM automated immunoassay system 显示文摘 | Josefina Mora-Brugues Neus Gascon-Roche | 1994 | Clin Chem1994，40，3： | 1 |
| 14 | Evaluation of Ciba Coming ACS:180TM automated immunoassay system显示文摘 | Josefina M B Neus G R | 1994 | Clin Chem1994，40，3： | 1 |
| 15 | Acute cardioembolic cerebral infarc- tion: answers to clinical questions 显示文摘 | Arboix Adria Allo Josefina | 2012 | Current Cardiology Re- views2012，8，1： | 1 |
| 16 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O’Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 17 | Cold and salt stress regulates the expression and activity of a chickpea cytosolic Cu/Zn superoside dismutase显示文摘 | Josefina Hernandez-Nistal Berta Dopico Emilia Labrador | 2002 | Plant Science2002，163，： | 1 |
| 18 | Patent foramen ovale closure in non-lacunar cryptogenic ischemic stroke:where are we now?显示文摘Patent foram ovale(PFO)is the most common anatomical cause of an interarterial shunt.It is usually asymptomatic but may cause paradoxical embolism and is a risk factor for non-lacunar cryptogenic cerebral ischemia in young adults.Although the first clinical trials did not show a significant superiority of PFO closure in the secondary prevention of cerebral ischemia as compared with standard antithrombotic treatment,six subsequent randomized clinical trials(CLOSURE I,PC Trial,RESPECT,CLOSE,REDUCE,and DEFENSE-PFO)performed in a sample of cryptogenic stroke in patients aged 60 years or younger provided evidence of a significant reduction of recurrent cerebral ischemia after percutaneous PFO closure.However,the use of percutaneous PFO closure cannot be generalized to the entire population of patients with cerebral ischemia and PFO,but it is indicated in highly selected patients with non-lacunar cryptogenic cerebral infarction with a large right-to-left shunt,an atrial septal aneurysm and no evidence of atrial fibrillation,as well as in association with antithrombotic treatment for an optimal secondary prevention of cerebral ischemia. | AdriàARBOIX Olga PARRA Josefina ALIÓ | 2021 | Journal of Geriatric Cardiology2021，18，1： | 1 |
| 19 | Intracerebral VEGF injection highly upregulates AQP4 mRNA and protein in the perivascular space and glia limitans externa 显示文摘 | Inmaculada R Alberto M Josefina C | 2008 | Neurochemistry International2008，52，45： | 1 |
| 20 | Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL显示文摘 | Weerapan Khovidhunkit Philippe N Duchateau Katalin F Medzihradszky Arthur H Moser Josefina Naya-Vigne Judy K Shigenaga John P Kane Carl Grunfeld Kenneth R Feingold | 2004 | Atherosclerosis2004，，1： | 1 |
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