|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet . 2011 (9791)2011，，： | 3 |
| 2 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 3 |
| 3 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 2 |
| 4 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | 2011 (9791)2011，，9791： | 2 |
| 5 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 1 |
| 6 | Imaging of mineral-entiched biochar by FrlR,Raman and SEM-EDX显示文摘 | Chia C.H Gong B Joseph S.D Marjo C.E Munroe P Rich A.M | | 0，，： | 1 |
| 7 | Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin显示文摘 | Yiting Cao Joseph M. Eble Ejung Moon Hong Yuan Douglas H. Weitzel Chelsea D. Landon Charleen Yu-Chih Nien Gabi Hanna Jeremy N. Rich James M. Provenzale Mark W. Dewhirst | 2013 | Cancer Research2013，，20： | 1 |
| 8 | Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation显示文摘Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects.However,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading processes.Herein,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome encapsulation.By synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is achieved.The final product consists of drug-loaded silica nanocarriers that are encased within an exosomal membrane.The drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the nanocarriers.Furthermore,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of minutes.These exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell proliferation.By utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications. | Zeyu Wang Joseph Rich Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang | 2022 | Microsystems & Nanoengineering2022，8，2： | 1 |
| 9 | 显示文摘 | Joseph O Rich Vadim V Mozhaev Jonathan S Dordick | 2002 | J Am Chem Soc2002，124，： | 1 |
| 10 | Programmes and principles in treatment of multidrug-resistant tuberculosis显示文摘 | Joia S Mukherjee Michael L Rich Adrienne R Socci J Keith Joseph Felix Alcántara Virú Sonya S Shin Jennifer J Furin Mercedes C Becerra Donna J Barry Jim Yong Kim Jaime Bayona Paul Farmer Mary C Smith Fawzi Kwonjune J Seung | 2004 | The Lancet2004，，9407： | 1 |
| 11 | Programmes and principles in treatment of multidrug-resistant tuberculosis显示文摘 | Mukherjee JS Rich ML Socci AR Joseph JK Viru FA Shin SS Furin JJ Becerra MC Barry DJ Kim JY Bayona J Farmer P Smith Fawzi MC Seung KJ | 2004 | Lancet2004，363，9407： | 1 |
| 12 | Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification显示文摘Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry,such as nucleic acids and proteins.However,most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously.In this work,we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction(HCR)signal amplification method.Specifically,exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase(HRP)attached using EpCAM aptamers as bridges.Subsequently,the current signal that is generated through the enzyme reaction between the HRP enzyme and 3,3,,5/5,-tetramethylbenzidine(TMB)/H_(2)0_(2) directly correlates to the amount of bound HRP on the HCR products and thus to the number of target exosomes.By introducing anti-EpCAM aptamers,micro-aptasensors can detect cancerous exosomes with high specificity.Due to the micropatterned electrodes and HCR dual-amplification strategy,the micro-aptasensors achieve a linear detection response for a wide range of exosome concentrations from 2.5×10^(3) to 1×10^(7) exosomes/mL,with a detection limit of 5×10^(2) exosomes/mL.Moreover,our method successfully detects lung cancer exosomes in serum samples of early-stage and late-stage lung cancer patients,showcasing the great potential for early cancer diagnosis. | Wenfen Zhang Zhenhua Tian Shujie Yang Joseph Rich Shuaiguo Zhao Mikael Klingeborn Po-Hsun Huang Zhishang Li Alexander Stout Quinn Murphy Edward Patz Shusheng Zhang Guozhen Liu Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，4： | 1 |
| 13 | Phospholipase D - catalyzed transphosphatidylation in anhydrous organic solvents 显示文摘 | Joseph O Rich Yuri L Khmelnitsky | 2001 | Biotechnology and bioengineering2001，72，3： | 1 |
| 14 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 1 |
| 15 | An acoustofluidic scanning nanoscope using enhanced image stacking and processing显示文摘Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material identification.Several scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical systems.To overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and location.Therefore,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous designs.Moreover,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or processes.This dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view. | Geonsoo Jin Joseph Rich Jianping Xia Albert JHe Chenglong Zhao Tony Jun Huang | 2022 | Microsystems & Nanoengineering2022，8，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员