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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | The inositol 1,4,5-trisphosphate receptor family 显示文摘 | Joseph SK | 1996 | Cell Signal1996，8，1： | 1 |
| 3 | Subcellular ROS imaging methods:relevance for the study of calcium sig- naling 显示文摘 | Booth DM Joseph SK Hajn6czky G | 2016 | Cell Calcium2016，60，2： | 1 |
| 4 | Identification of ex- pression signatures predictive of sensitivity to the Bcl-2 family Member Inhibitor ABT- 263 in small cell Lung Carcinoma and Leukemia/Lymphoma cell lines 显示文摘 | Tahir SK Wass J Joseph MK | 2010 | Mol Cancer Ther2010，9，3： | 1 |
| 5 | A Prospective, Molecular Epi- demiology Study of Adenocarcinoma Histology (PIONEER) 显示文摘 | Shi Y Joseph Sk Thongprasert S | 2014 | Jour- nal of Thoracic Oncology2014，9，2： | 1 |
| 6 | Dose-Response Relationship be-tween Cooking Fumes Exposures and Lung Cancer among Chinese Non-smoking Women显示文摘 | Yuk LC Joseph SK | 2006 | Cancer Research2006，66，8： | 1 |
| 7 | IP3 receptors in cell survival and ap- optosis: Ca2+ release and beyond 显示文摘 | Joseph SK Hajn6czky G | 2007 | Apoptosis2007，12，5： | 1 |
| 8 | Evaluation of anti-pyretic and analgesic activity of Emblica officinalis显示文摘 | Perianayagam JB Sharma SK Joseph A | 2004 | Journal of Ethnopharmacology2004，95，： | 1 |
| 9 | A meta-analysis of clinical screening tests for obstructive sleep apnea 显示文摘 | Ramachandran SK Josephs LA | 2009 | Anesthesiology2009，110，4： | 1 |
| 10 | IP3 receptors in cell survival and apoptosis : Ca2 + release and beyond 显示文摘 | Joseph SK Hajnoczky G | 2007 | Apoptosis2007，12，5： | 1 |
| 11 | With regards to optimal closure method of five-millimeter trocar sites 显示文摘 | Raul SK Joseph SC | 2004 | Am J Surg2004，187，1： | 1 |
| 12 | Com- bating the illegal trade in African elephant ivory with DNA forensics显示文摘 | Wasser SK Joseph Clark W Drori O | 2008 | Conserv Biol2008，22，4： | 1 |
| 13 | Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn显示文摘 | Sharrna SK Joseph A | 2004 | Journal of Ethnopharmacology2004，95，1： | 1 |
| 14 | Treatment results for nasopharyngeal carcinoma in the modern era:The Hong Kong experience显示文摘 | Anne WM Lee FR Joseph SK | 2005 | Int J Radiat Oncol Biol Phys2005，61，： | 1 |
| 15 | Protection against filar- ial infection by 45- 49 kDa molecules of Brugiamalayi via IFN- gamma-mediated iNOS induction显示文摘 | Verma SK Joseph SK Verma R | 2015 | Vaccine2015，33，4： | 1 |
| 16 | Noise consideration in dual energy CT scanning显示文摘 | Kelcz F Joseph PM Hilal SK | 1979 | Med Phys1979，6，5： | 1 |
| 17 | IgG subclass respons- es to proinflammatory fraction of Brugia malayi in human filaria- sis显示文摘 | Joseph SK Verma SK Sahoo MK et 01 | 2012 | Indian J Med Res2012，135，5： | 1 |
| 18 | Biliary peritonitis requiring reoperation after removal of T - tubes from the common bile duct 显示文摘 | | 2007 | Am J Surg2007，193，2： | 1 |
| 19 | Effect of Oxidized Glutathione and Temperature on Inositol 1,4,5 trisphosphate Binding in Permeabilized Hepatocytes 显示文摘 | Renard RDC Joseph SK Seitz MB | 1995 | Biochem J1995，310，2： | 1 |
| 20 | A meta-analysis of clinical screening tests for obstructive sleep apnea 显示文摘 | Ramachandran SK Josephs LA | 2009 | Anesthesiology2009，110，4： | 1 |
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